The DOI matches its Crossref record.
Correlations between changes in disability and T 2 ‐weighted brain MRI activity in multiple sclerosis: A follow‐up study
Abstract
We obtained two conventional unenhanced T2-weighted brain MRI scans, separated by an interval of 24 to 36 months, in 281 patients with multiple sclerosis (MS). At the time of each scan, clinical disability was rated using the Kurtzke Expanded Disability Status Scale (EDSS). Changes in disability between the two examinations correlated weakly but significantly with the number of new (Spearman's rank correlation coefficient = 0.13; p = 0.02) and enlarging (Spearman's rank correlation coefficient = 0.18; p = 0.002) MRI lesions. This result suggests that brain T2-weighted MRI is a useful supplementary marker of disease activity in definitive (phase III) clinical treatment trials in MS.
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Citations
Cited by
Kappos, L., Moeri, D., Radue, E. W., Schoetzau, A., Schweikert, K., Barkhof, F., Miller, D., Guttmann, C. R., Weiner, H. L., Gasperini, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03053-0 · Cited by 499
Self-citationImaging axonal damage of normal-appearing white matter in multiple sclerosis
Fu, L. (1998) · Brain · doi:10.1093/brain/121.1.103 · Cited by 481
Miller, D. H., Albert, P. S., Barkhof, F., Francis, G., Frank, J. A., Hodgkinson, S., Lublin, F. D., Paty, D. W., Reingold, S. C., & Simon, J. (1996) · Annals of Neurology · doi:10.1002/ana.410390104 · Cited by 444
Self-citationNijeholt, G. (1998) · Brain · doi:10.1093/brain/121.4.687 · Cited by 381
Multiple sclerosis normal‐appearing white matter: Pathology–imaging correlations
Moll, N. M., Rietsch, A. M., Thomas, S., Ransohoff, A. J., Lee, J., Fox, R., Chang, A., Ransohoff, R. M., & Fisher, E. (2011) · Annals of Neurology · doi:10.1002/ana.22521 · Cited by 297
Metadata
- Authors
- Filippi, M., Paty, D. W., Kappos, L., Barkhof, F., Compston, D. A. S., Thompson, A. J., Zhao, G. J., Wiles, C. M., McDonald, W. I., & Miller, D. H.
- Venue
- Neurology
- Published
- 1995-02
- Volume
- 45
- Issue
- 2
- Pages
- 255-260
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2042785717
- Cited by
- 296
- References
- 0
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Correlations between changes in disability and T 2 ‐weighted brain MRI activity in multiple sclerosis: A follow‐up study. https://app.cochat.ai/papers/10.1212/wnl.45.2.255
- The paper
- Filippi, M., Paty, D. W., Kappos, L., Barkhof, F., Compston, D. A. S., Thompson, A. J., Zhao, G. J., Wiles, C. M., McDonald, W. I., & Miller, D. H. (1995). Correlations between changes in disability and T 2 ‐weighted brain MRI activity in multiple sclerosis: A follow‐up study. Neurology. https://doi.org/10.1212/wnl.45.2.255
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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