The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA
Abstract
The Hu antigens are composed of a family of neuronal-specific, RNA-binding proteins encoded by at least three distinct genes. All three gene products, HuD, HuC/ple21, and Hel-N1, are human homologues of Elav, a Drosophila protein required for neuronal development and maintenance. Although the three proteins are very similar in structure, they are differentiated by alternative splicing of their mRNAs. We report here that the Hu antigens bind avidly to the AU-rich element resident in many mRNAs that regulate cell proliferation. This interaction suggests that the Hu antigens promote neuronal differentiation by suppressing the neuroblast cell cycle. Such a mechanism provides a plausible model for the role of the Hu antigens in tumorigenesis, neuronal differentiation, and paraneoplastic neurologic disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The HuD protein, like all Hu members, has a molecular weight of ∼40 kDa and contains three RNA recognition motifs (RRMs) with a linker region separating the second and third RRM (Fig. 1C; Good 1995; Liu et al. 1995; Okano and Darnell 1997).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Liu et al. 1995
In the citing paper
“Using REMSAs, the authors showed that HuD binds specifically to an ARE sequence in the c-fos 3′ UTR.”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Liu et al. 1995
In the citing paper
“Numerous other ARE-harboring transcripts, such as N-myc and c-myc, were later identified as targets of HuD using similar in vitro approaches, indicating that HuD binds short-lived mRNAs whose protein product functions in cell proliferation (Liu et al. 1995; Ross et al. 1997).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Liu et al. 1995
Citations
Cites
Dalmau, J., Graus, F., Rosenblum, M. K., & Posner, J. B. (1992) · MEDICINE · doi:10.1097/00005792-199203000-00001 · Cited by 819
Self-citationRNA recognition: towards identifying determinants of specificity
Kenan, D. J., Query, C. C., & Keene, J. D. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90088-d · Cited by 724
Drosophila Mushroom Body Mutants are Deficient in Olfactory Learning
Heisenberg, M., Borst, A., Wagner, S., & Byers, D. (1985) · Journal of Neurogenetics · doi:10.3109/01677068509100140 · Cited by 697
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.Preprint
Shyu, A. B., Greenberg, M. E., & Belasco, J. G. (1989) · Genes & Development · doi:10.1101/gad.3.1.60 · Cited by 575
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553
Self-citationShyu, A. B., Belasco, J. G., & Greenberg, M. E. (1991) · Genes & Development · doi:10.1101/gad.5.2.221 · Cited by 523
Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer
Crawford, L. V., Pim, D. C., & Bulbrook, R. D. (1982) · International Journal of Cancer · doi:10.1002/ijc.2910300404 · Cited by 448
Dalmau, J. O., Furneaux, H. M., Gralla, R. J., Kris, M. G., & Posner, J. B. (1990) · Annals of Neurology · doi:10.1002/ana.410270515 · Cited by 391
Self-citationNeuronal antinuclear antibody in sensory neuronopathy from lung cancer
Graus, F., Cordon‐Cardo, C., & Posner, J. B. (1985) · Neurology · doi:10.1212/wnl.35.4.538 · Cited by 367
Levine, T., Gao, F., King, P. H., Andrews, L. G., & Keene, J. D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3494 · Cited by 356
Flagged first, then by citations
Research works printed but not linked: 15
- Russell DS. Encephalomyelitis and carcinomatous neuropathy. In: Bogaert LV Radermecker J Hozay J Lowenthal A eds. The encephalitides. Amsterdam: Elsevier 1961:131-135.
- Henson RA Urich H. Cancer and the nervous system. Oxford UK: Blackwell Scientific 1982:314-345.
- Altermatt H, Rodriguez M, Scheithauer B, Lennon V. Paraneoplastic anti-Purkinje and type-I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral and autonomic nervous system cells. Lab Invest 1991;65:412-420.
- Lennon VA. Paraneoplastic autoantibodies: the case for a descriptive generic nomenclature. Neurology 1994;44:2236-2240.
- Posner JB Furneaux HM. Paraneoplastic syndromes. In: Waksman BH ed. Immunologic mechanisms in neurologic and psychiatric disease. New York: Raven Press 1990:187-219.
- Manley G. Identification and analysis of anti-Hu paraneoplastic antigens (doctoral dissertation). New York: Cornell University Medical College 1994.
- Robinow S, White K. The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev Biol 1988;126:294-303.
- Yao K-M, Samson M-L, Reeves R, White K. Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J Neurobiol 1993;24:723-739.
- Sachs AB. Messenger RNA degradation in eukaryotes. Cell 1993;74:413-421.
- You Y, Chen C-YA, Shyu A-B. U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol Cell Biol 1992;12:2931-2940.
- Szabo A. Cloning and characterization of HuD: a human brain paraneoplastic antigen (doctoral dissertation). New York: Cornell University Graduate School of Medical Sciences 1993.
- Shaw G, Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986;46:659-667.
- Barami K Iversen K Furneaux H Goldman S. Early expression of Hu a specific marker of neuronal differentiation by newly postmitotic subependymal zone cells of the adult songbird forebrain. J Neurobiol (in press).
- Winter S, Minna J, Johnson B, Takahashi T, Gazdar A, Carbone D. Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of mutation. Cancer Res 1992;52:4168-4174.
- Dalmau J, Graus F, Cheung V-K, et al. Major histocompatibility (MHC) proteins, anti-Hu antibodies and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 1995;75:99-109.
Cited by
Sorted by citations
Items 101–123 of 123
Rauer, S., & Kaiser, R. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103004248.x · Cited by 11
Perron, M., BOURLITIO, P., Wegnez, M. R., & Théodore, L. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.579 · Cited by 11
Kumagai, T., Kitagawa, Y., Hirose, G., & Sakai, K. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00184-2 · Cited by 10
Principles of Paraneoplastic Syndromes
Dropcho, E. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10934.x · Cited by 9
Willison, H. J., Gregson, N. A., O’Hanlon, G. M., & Hughes, R. A. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50029-6 · Cited by 6
Precocious Expression of Drosophila Rbp9 Inhibits Ovarian Germ Cell Proliferation
Jeong, K., & Kim‐Ha, J. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13106-2 · Cited by 6
THE CLINICAL SPECTRM AND PATHOGENESIS OF PARANEOPLASTIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM
Rosenfeld, M. R., & Dalmau, J. O. (2001) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70270-7 · Cited by 6
Self-citationParaneoplastic encephalomyelitis: A case report and review of the literature
Duff, M., Dusenbery, K. E., & Rodriguez, F. J. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.03.031 · Cited by 3
Neuronal Nuclear Autoantibodies, Type 1 (Hu)
Furneaux, H. M. (1996) · Elsevier eBooks · doi:10.1016/b978-044482383-0/50085-6 · Cited by 2
Self-citationParaneoplastic Autoimmune Reactions
Sivinski, C. L., Tempero, R. M., VanLith, M. L., & Hollingsworth, M. A. (1999) · Humana Press eBooks · doi:10.1007/978-1-4612-1610-0_22 · Cited by 2
Anti-Hu antibody and refractory nonconvulsive status epilepticus
Greenlee, J. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.03.001 · Cited by 2
Interactions of Proteins with Specific Sequences in RNA
Andrews, L. G., & Keene, J. D. (1997) · Elsevier eBooks · doi:10.1016/b978-012587545-5/50014-8 · Cited by 2
Antibodies to Intracellular Antigens in CNS Disorders
Dalmau, J. O., & Graus, F. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108696722.005 · Cited by 1
Self-citationParaneoplastische Erkrankungen des Zentralnervensystems aus neurologischer und internistischer Sicht
Schröder, M., & Pongratz, D. E. (2001) · Der Internist · doi:10.1007/s001080170107 · Cited by 1
"Yersinia enterocolitica" associated with gastroenteritis and leukopenia.
Giraldi, V., Chiesa, C., Romagnoli, E., & Midulla, M. (1979) · PubMed · Cited by 1
Immunological Mechanisms of Paraneoplastic Nervous System Diseases
Giometto, B., Nicolao, P., Scaravilli, T., Vianello, M., Vitaliani, B., Ferrarini, A. M., & Tavolato, B. F. (2002) · Springer eBooks · doi:10.1007/978-88-470-2097-9_8
directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro
Ahn, J.-W., Byeon, I. L., Dharmasena, S., Huber, K. D., Concel, J., Gronenborn, A. M., & Sluis‐Cremer, N. (2010)
A Woman with Difficulty Walking and Ataxia
Bertorini, T. E. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7332-7.50073-8
Coordinating Cell Cycle Exit and Differentiation in the Mammalian Retina and its Dependence on Rb
Pacal, M. (2012) · TSpace (University of Toronto)
Paraneoplastic Neurologic Disease
Zalewski, N. L., & Pittock, S. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-16928-2_15
Wilhelm, C. (2002) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-142
Metadata
- Authors
- Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J., & Furneaux, H.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Neurology
- Published
- 1995-03
- Volume
- 45
- Issue
- 3
- Pages
- 544-550
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2045309201
- Cited by
- 122
- References
- 33
- Citations by year
- 2025: 1 · 2022: 2 · 2019: 1 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns029682-04)
- National Cancer Institute (CA-09512, T32CA009512)
- National Institute of Neurological Disorders and Stroke (NS29682)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Keywords
- paraneoplastic encephalomyelitis, AU-rich elements, RNA-binding proteins, HUD, alternative splicing, mRNA stability, cell cycle regulation, neuronal differentiation, neuroblastoma, carcinogenesis
- MeSH terms
- ELAV-Like Protein 4, Amino Acid Sequence, Base Sequence, Encephalomyelitis, Exons, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Paraneoplastic Syndromes, RNA, Messenger, RNA, Neoplasm, RNA-Binding Proteins, Genes, fos, ELAV Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
