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Cited by 123Autoimmune Neurological Disorders and TreatmentsRNA Research and SplicingMonoclonal and Polyclonal Antibodies Research

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA

Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J., Furneaux, H.·1995·Neurology
DOI 10.1212/wnl.45.3.544
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Abstract

The Hu antigens are composed of a family of neuronal-specific, RNA-binding proteins encoded by at least three distinct genes. All three gene products, HuD, HuC/ple21, and Hel-N1, are human homologues of Elav, a Drosophila protein required for neuronal development and maintenance. Although the three proteins are very similar in structure, they are differentiated by alternative splicing of their mRNAs. We report here that the Hu antigens bind avidly to the AU-rich element resident in many mRNAs that regulate cell proliferation. This interaction suggests that the Hu antigens promote neuronal differentiation by suppressing the neuroblast cell cycle. Such a mechanism provides a plausible model for the role of the Hu antigens in tumorigenesis, neuronal differentiation, and paraneoplastic neurologic disorders.

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Crossref · 10.1212/wnl.45.3.544

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Show all 33 references

Research works printed but not linked: 15

  1. Russell DS. Encephalomyelitis and carcinomatous neuropathy. In: Bogaert LV Radermecker J Hozay J Lowenthal A eds. The encephalitides. Amsterdam: Elsevier 1961:131-135.
  2. Henson RA Urich H. Cancer and the nervous system. Oxford UK: Blackwell Scientific 1982:314-345.
  3. Altermatt H, Rodriguez M, Scheithauer B, Lennon V. Paraneoplastic anti-Purkinje and type-I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral and autonomic nervous system cells. Lab Invest 1991;65:412-420.
  4. Lennon VA. Paraneoplastic autoantibodies: the case for a descriptive generic nomenclature. Neurology 1994;44:2236-2240.
  5. Posner JB Furneaux HM. Paraneoplastic syndromes. In: Waksman BH ed. Immunologic mechanisms in neurologic and psychiatric disease. New York: Raven Press 1990:187-219.
  6. Manley G. Identification and analysis of anti-Hu paraneoplastic antigens (doctoral dissertation). New York: Cornell University Medical College 1994.
  7. Robinow S, White K. The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev Biol 1988;126:294-303.
  8. Yao K-M, Samson M-L, Reeves R, White K. Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J Neurobiol 1993;24:723-739.
  9. Sachs AB. Messenger RNA degradation in eukaryotes. Cell 1993;74:413-421.
  10. You Y, Chen C-YA, Shyu A-B. U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol Cell Biol 1992;12:2931-2940.
  11. Szabo A. Cloning and characterization of HuD: a human brain paraneoplastic antigen (doctoral dissertation). New York: Cornell University Graduate School of Medical Sciences 1993.
  12. Shaw G, Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986;46:659-667.
  13. Barami K Iversen K Furneaux H Goldman S. Early expression of Hu a specific marker of neuronal differentiation by newly postmitotic subependymal zone cells of the adult songbird forebrain. J Neurobiol (in press).
  14. Winter S, Minna J, Johnson B, Takahashi T, Gazdar A, Carbone D. Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of mutation. Cancer Res 1992;52:4168-4174.
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Metadata

Authors
Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J., & Furneaux, H.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1995-03
Volume
45
Issue
3
Pages
544-550
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.45.3.544
OpenAlex
W2045309201
Cited by
122
References
33
Citations by year
2025: 1 · 2022: 2 · 2019: 1 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
13.43
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns029682-04)
  • National Cancer Institute (CA-09512, T32CA009512)
  • National Institute of Neurological Disorders and Stroke (NS29682)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Keywords
paraneoplastic encephalomyelitis, AU-rich elements, RNA-binding proteins, HUD, alternative splicing, mRNA stability, cell cycle regulation, neuronal differentiation, neuroblastoma, carcinogenesis
MeSH terms
ELAV-Like Protein 4, Amino Acid Sequence, Base Sequence, Encephalomyelitis, Exons, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Paraneoplastic Syndromes, RNA, Messenger, RNA, Neoplasm, RNA-Binding Proteins, Genes, fos, ELAV Proteins

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