HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal
Abstract
A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.
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Aberrant expression or function of HuD has been detected in several cancers of the central and peripheral nervous system, most prominently neuroblastomas and small cell lung cancers.
“Aberrant expression or function of HuD has been detected in several cancers of the central and peripheral nervous system, most prominently NBs and SCLCs (Szabo et al. 1991; Dalmau et al. 1992; Chagnovich and Cohn 1996; Ball and King 1997; Schramm et al. 1999; Stawski et al. 2012).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Szabo et al. 1991
nELAVLs are target antigens in patients with paraneoplastic neurological disorders.
“Like NOVA, nELAVLs are target antigens in patients with paraneo-plastic neurological disorders121,122.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [121]
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- Authors
- Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-10-18
- Volume
- 67
- Issue
- 2
- Pages
- 325-333
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2035869111
- Cited by
- 553
- References
- 21
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 3 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 12
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-09512, CA-09512-06, T32CA009512)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- HUD, paraneoplastic encephalomyelitis, small cell lung cancer, neuronal antigens, RNA-binding domain, Sex-lethal, Drosophila homology, tumor-infiltrating lymphocytes, sensory neuronopathy
- MeSH terms
- ELAV-Like Protein 4, Amino Acid Sequence, Animals, Antigens, Neoplasm, Base Sequence, Brain, Cloning, Molecular, Drosophila, Encephalomyelitis, Humans, Lung Neoplasms, Lymphocytes, Molecular Sequence Data, Nerve Tissue Proteins, Paraneoplastic Syndromes, Recombinant Fusion Proteins, Ribonucleoproteins, RNA, Messenger, Sequence Homology, Nucleic Acid, Gene Expression, RNA-Binding Proteins, Carcinoma, Small Cell, ELAV Proteins
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