Cited by 553Autoimmune Neurological Disorders and TreatmentsRNA Research and SplicingMonoclonal and Polyclonal Antibodies Research

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal

Szabo, Aniko, Dalmau, Josep, Manley, Geoff, Rosenfeld, Myrna, Wong, Ellen, Henson, John, Posner, Jerome B., Furneaux, Henry M.·1991·Cell

Abstract

A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.

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Crossref · 10.1016/0092-8674(91)90184-z

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  • Aberrant expression or function of HuD has been detected in several cancers of the central and peripheral nervous system, most prominently neuroblastomas and small cell lung cancers.

    “Aberrant expression or function of HuD has been detected in several cancers of the central and peripheral nervous system, most prominently NBs and SCLCs (Szabo et al. 1991; Dalmau et al. 1992; Chagnovich and Cohn 1996; Ball and King 1997; Schramm et al. 1999; Stawski et al. 2012).”
  • nELAVLs are target antigens in patients with paraneoplastic neurological disorders.

    “Like NOVA, nELAVLs are target antigens in patients with paraneo-plastic neurological disorders121,122.”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [121]

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Authors
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Venue
Cell
Publisher
Elsevier BV
Published
1991-10-18
Volume
67
Issue
2
Pages
325-333
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2035869111
Cited by
553
References
21
Citations by year
2026: 3 · 2025: 2 · 2024: 11 · 2023: 3 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 12
FWCI
16.16
Type
journal article
Language
en
Open access
closed
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA-09512, CA-09512-06, T32CA009512)
Topics
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
Keywords
HUD, paraneoplastic encephalomyelitis, small cell lung cancer, neuronal antigens, RNA-binding domain, Sex-lethal, Drosophila homology, tumor-infiltrating lymphocytes, sensory neuronopathy
MeSH terms
ELAV-Like Protein 4, Amino Acid Sequence, Animals, Antigens, Neoplasm, Base Sequence, Brain, Cloning, Molecular, Drosophila, Encephalomyelitis, Humans, Lung Neoplasms, Lymphocytes, Molecular Sequence Data, Nerve Tissue Proteins, Paraneoplastic Syndromes, Recombinant Fusion Proteins, Ribonucleoproteins, RNA, Messenger, Sequence Homology, Nucleic Acid, Gene Expression, RNA-Binding Proteins, Carcinoma, Small Cell, ELAV Proteins

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