Distinct cognitive profiles of cortical and subcortical dementia in advanced illness
Abstract
We administered the Mattis Dementia Rating Scale (DRS) to 120 patients to evaluate the effect of dementia severity on distinct cognitive profiles. Sixty patients with Huntington's disease (HD) and 60 patients with Alzheimer's disease (AD) were separated by dementia severity into three groups: mildly demented (DRS mean total = 129), moderately demented (DRS mean total = 117), and severely demented (DRS mean total = 102). At all levels of dementia severity, HD patients demonstrated greater impairment than AD patients on the Initiation/Perseveration subscale, whereas AD patients demonstrated greater impairment than HD patients on the Memory subscale. At moderate and severe levels of dementia, HD patients demonstrated an additional impairment in constructional praxis. These profile differences were independent of dementia severity and continued to differentiate between so-called cortical and subcortical dementias in later stages of dementia severity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In cortical dementia and amnestic conditions, encoding, delayed recall, cued recall, and delayed recognition are all impaired.
“in cortical dementia and amnestic conditions encoding, delayed recall, cued recall, and delayed recognition are all impaired”
From Domains of cognition and their assessment (2019) · cites this paper as [50]
Naming deficits are more commonly seen in cortical dementia than in frontostriatal conditions.
“both cortical and frontostriatal conditions adversely impact verbal fluency, but naming deficits are more commonly seen in cortical dementia. 50”
From Domains of cognition and their assessment (2019) · cites this paper as [50]
Both cortical and frontostriatal conditions adversely impact verbal fluency.
“both cortical and frontostriatal conditions adversely impact verbal fluency, but naming deficits are more commonly seen in cortical dementia. 50”
From Domains of cognition and their assessment (2019) · cites this paper as [50]
In frontostriatal conditions, encoding and delayed recall are impaired, but delayed recognition and cued recall are typically spared.
“while in frontostriatal conditions encoding and delayed recall are impaired, but delayed recognition and cued recall are typically spared. 50 - 51”
From Domains of cognition and their assessment (2019) · cites this paper as [50]
Cited by
Sorted by citations
Domains of cognition and their assessment
Harvey, P. D. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.3/pharvey · Cited by 695 · see citing works
Neuropsychiatric aspects of Huntington’s disease.
Paulsen, J. S. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.3.310 · Cited by 486 · see citing works
Self-citationCognitive Impairment in Huntington Disease: Diagnosis and Treatment
Paulsen, J. S. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0215-x · Cited by 364 · see citing works
“In contrast, older memories of names and dates are often unaffected in persons with HD [53], even as they develop impairments in implicit, or unconscious, memory.”
Self-citationBrain imaging and cognitive dysfunctions in Huntington’s disease
Montoya, A. G., Price, B. H., Menear, M., & Lepage, M. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0603 · Cited by 265 · see citing works
“Compared with control subjects, patients with HD have shown impairments in overall processing capacity and spatial manipulation domains.(16,18)”
Dayalu, P., & Albin, R. L. (2014) · Neurologic Clinics · doi:10.1016/j.ncl.2014.09.003 · Cited by 230 · see citing works
New Avenues for the Treatment of Huntington’s Disease
Kim, A. M., Lalonde, K. M., Truesdell, A., Welter, P. G., Brocardo, P. S., Rosenstock, T. R., & Gil‐Mohapel, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168363 · Cited by 198 · see citing works
“As stated above, the cognitive deficits seen in HD are thought to be primarily subcortical and include decreased processing speed, poor attention, poor problem-solving abilities, and poor memory retrieval [188].”
BackgroundBuffon, F. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.068726 · Cited by 177 · see citing works
Huntington’s Disease—Update on Treatments
Wyant, K. J., Ridder, A. J., & Dayalu, P. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0739-9 · Cited by 147 · see citing works
Porto, C. S., Charchat‐Fichman, H., Caramelli, P., et al. (2003) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2003000300004 · Cited by 140 · see citing works
Cognitive Profiles of Autopsy-Confirmed Lewy Body Variant vs Pure Alzheimer Disease
Connor, D. J., Salmon, D. P., Sandy, T. J., Galasko, D. R., Hansen, L. A., & Thal, L. J. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.994 · Cited by 119 · see citing works
Self-citationJanvin, C. C., Larsen, J. P., Salmon, D. P., Galasko, D. R., Hugdahl, K., & Aarsland, D. (2005) · Movement Disorders · doi:10.1002/mds.20726 · Cited by 119 · see citing works
Self-citationEpisodic memory impairment in Huntington's disease: A meta-analysis
Montoya, A. G., Pelletier, M., Menear, M., Duplessis, E., Richer, F., & Lepage, M. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.01.015 · Cited by 108 · see citing works
Huntington Disease and the Related Disorder, Dentatorubral-Pallidoluysian Atrophy (DRPLA)
Ross, C. A., Margolis, R. L., Rosenblatt, A., Ranen, N. G., Bêcher, M. W., & Aylward, E. (1997) · Medicine · doi:10.1097/00005792-199709000-00001 · Cited by 101 · see citing works
BRAATEN, A. J., PARSONS, T. D., McCUE, R., SELLERS, A., & BURNS, W. J. (2006) · International Journal of Neuroscience · doi:10.1080/00207450600920928 · Cited by 98 · see citing works
“These findings are partially consistent with previous literature, which suggests that abnormalities in attention are a common finding in dementia with a subcortical component (Lezak, 1995; Paulsen et al., 1995).”
ResultSTARKSTEIN, S. E., Sabe, L., Petracca, G., Chemerinski, E., Kuzis, G., Merello, M., & Leiguarda, R. C. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.4.381 · Cited by 93 · see citing works
Executive and emotional dysfunction in Machado‐Joseph disease
Zawacki, T. M., Grace, J., Friedman, J. H., & Sudarsky, L. R. (2002) · Movement Disorders · doi:10.1002/mds.10033 · Cited by 92 · see citing works
Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome
Bourgeois, J. A., Cogswell, J. B., Hessl, D. R., Zhang, L., Ono, M. Y., Tassone, F., Farzin, F., Brunberg, J. A., Grigsby, J., & Hagerman, R. J. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.03.003 · Cited by 91 · see citing works
NEUROPSYCHOLOGICAL PROFILE OF “COGNITIVE FRAILTY” SUBJECTS IN MAPT STUDY
Delrieu, J., Andrieu, S., Pahor, M., Cantet, C., Cesari, M., Ousset, P., Voisin, T., Fougère, B., Guyonnet, S., Carrié, I., et al. (2016) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2016.94 · Cited by 90 · see citing works
Fama, R., Sullivan, E., Shear, P., Marsh, L., Yesavage, J., Tinklenberg, J., Lim, K. O., & Pfefferbaum, A. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550180039010 · Cited by 85 · see citing works
Una propuesta de aplicación y puntuación del test del reloj en la enfermedad de Alzheimer
Gutiérrez, L. J. C., García, R. G., Navarro, J. A., Villardón, J. L. V., & Puebla, N. L. (1999) · Revista de Neurología · doi:10.33588/rn.2807.98501 · Cited by 80 · see citing works
Chan, A. S.-Y., Choi, A. L. Y., Chiu, H. F. K., & LAM, L. C. W. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703910058 · Cited by 79 · see citing works
“…the DRS is found to be useful in differentiating AD patients from patients with Parkinson’s disease (Paolo et al., 1995), Huntington’s disease (Paulsen et al., 1995; Salmon et al., 1989b), Lewy Body Variant of AD (Connor et al., 1998), and Progressive supranuclear palsy (Rosser & Hodges,…”
BackgroundResultCognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms
Giralt, A., Saavedra, A., Alberch, J., & Pérez‐Navarro, E. (2012) · Journal of Huntington s Disease · doi:10.3233/jhd-120023 · Cited by 76 · see citing works
Chan, A. S.-Y., Choi, M. K., & Salmon, D. P. (2001) · The Journals of Gerontology Series B · doi:10.1093/geronb/56.6.p356 · Cited by 72 · see citing works
“…among patients with distinct dementing disorders on the basis of the pattern of subtest scores they achieve (Hersch, 1979; Paolo, Troster, Glatt, Hubble, & Koller, 1995; Paulsen et al., 1995; Rosser & Hodges, 1994; Salmon, Kwo-on-Yuen, et al., 1989; Troster, Moe, Vitiello, & Prinz, 1994).”
BackgroundSelf-citationSullivan, E. V., Shear, P. K., Zipursky, R. B., et al. (1997) · Neuropsychology · doi:10.1037/0894-4105.11.2.195 · Cited by 71 · see citing works
Neuropsychological Assessment of Severely Demented Elderly
Peavy, G. M. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550040107020 · Cited by 67 · see citing works
Reconciling Successful Aging with HIV
Vance, D. E., & Robinson, F. P. (2004) · Journal of HIV/AIDS & Social Services · doi:10.1300/j187v03n01_06 · Cited by 62 · see citing works
“Furthermore, subcortical diseases, such as Parkinson’s disease, that damage the basal ganglia and cause psychomotor impairment, generally increase in frequency with age (Paulsen et al., 1995).”
BackgroundRosenstein, L. D. (1998) · Neuropsychology Review · doi:10.1023/a:1025628925796 · Cited by 63 · see citing works
Frontal Behavioral Syndromes in Cortical and Subcortical Dementia
Paulsen, J. S., Stout, J. C., DeLaPena, J., Romero, R., Tawfik-Reedy, Z., Swenson, M. R., Grace, J., & Malloy, P. F. (1996) · Assessment · doi:10.1177/1073191196003003012 · Cited by 58 · see citing works
Self-citationRating scales for cognition in Huntington's disease: Critique and recommendations
Mestre, T., Bachoud‐Lévi, A., Marinus, J., Stout, J. C., Paulsen, J. S., Como, P. G., Duff, K., Sampaio, C., Goetz, C. G., Cubo, E., et al. (2017) · Movement Disorders · doi:10.1002/mds.27227 · Cited by 55 · see citing works
Self-citationRascovsky, K., Salmon, D. P., Hansen, L. A., & Galasko, D. R. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770808051x · Cited by 52 · see citing works
“, 1995), Huntington’s disease (Paulsen et al., 1995; Rosser & Hodges, 1994; Salmon et al., 1989), and progressive supranuclear palsy (Rosser & Hodges, 1994).”
Self-citationRoyall, D. R., & Polk, M. J. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01022.x · Cited by 50 · see citing works
Smith, M. M., The PREDICT-HD Investigators of the Huntington Study Group, Mills, J. A., et al. (2012) · Neuropsychology · doi:10.1037/a0029218 · Cited by 47 · see citing works
Self-citationMayo's Older African American Normative Studies: Norms for the Mattis Dementia Rating Scale
Rilling, L. M., Lucas, J. A., Ivnik, R. J., Smith, G. E., Willis, F. B., Ferman, T. J., Petersen, R. C., & Graff‐Radford, N. R. (2005) · The Clinical Neuropsychologist · doi:10.1080/13854040590945328 · Cited by 46 · see citing works
Attentional deficits in Alzheimer's, Parkinson's, and Huntington's diseases
Claus, J. J., & Mohr, E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00007.x · Cited by 46 · see citing works
Variable memory profiles in parkinson's disease
Filoteo, J. V., Rilling, L. M., Cole, B., et al. (1997) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639708403768 · Cited by 44 · see citing works
Hohl, U., Grundman, M., Salmon, D. P., Thomas, R. G., & Thal, L. J. (1999) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617799544019 · Cited by 43 · see citing works
“The Memory subtest of the DRS is particularly sensitive to the effects of dementia (Monsch et al., 1995; Paulsen et al., 1995) and it may be the case that the Hispanic AD patients are more demented than their MMSE scores suggest.”
BackgroundSelf-citationMattioli, F., Capra, R., Rovaris, M., et al. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00015-1 · Cited by 42 · see citing works
“On the contrary, the pattern of SSV-related cognitive impairment is closer to that observed in other CNS diseases predominantly involving subcortical structures, such as Huntington’s disease, Parkinson’s disease and multiple sclerosis (MS), which has been named as subcortical dementia [25].”
ResultCognitive screening and neuropsychological assessment in early alzheimer's disease
Salmon, D. P., & Lange, K. L. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70067-7 · Cited by 39 · see citing works
Self-citationLibon, D. J., Bogdanoff, B., Bonavita, J., Skalina, S., Cloud, B., Resh, R., Cass, P., & Ball, S. K. (1997) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/12.3.239 · Cited by 37 · see citing works
Cognitive dysfunction in H untington's disease: mechanisms and therapeutic strategies beyond BDNF
Puigdellívol, M., Saavedra, A., & Pérez‐Navarro, E. (2016) · Brain Pathology · doi:10.1111/bpa.12432 · Cited by 37 · see citing works
“Importantly, in middle and more advanced disease stages, a global cognitive decline is observed in patients with HD (7, 156, 218, 346).”
BackgroundEvans, J. D., Negrón, A. E., Palmer, B. W., et al. (1999) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879901200104 · Cited by 36 · see citing works
Self-citationFoss, M. P., Carvalho, V. A., Machado, T. H., dos Reis, G. C., Tumas, V., Caramelli, P., Nitríni, R., & Porto, C. S. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn74000004 · Cited by 35 · see citing works
“Dement Neuropsychol 2013 December;7(4):374-379”
RETRACTED: Cognitive Frailty: Mechanisms, Tools to Measure, Prevention and Controversy
Fougère, B., Delrieu, J., del Campo, N., Soriano, G., Sourdet, S., & Vellas, B. J. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.03.001 · Cited by 35 · see citing works
RetractedMouse pharmacological models of cognitive disruption relevant to schizophrenia
Young, J. W., Powell, S. B., & Geyer, M. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.013 · Cited by 32 · see citing works
“Lack of cognitive improvement from FGAs could be related to co-administration of anti-cholinergic drugs (Keefe et al., 1999; Paulsen et al., 1995; Spohn and Strauss, 1989), used to counter the extra-pyramidal side-effects of FGA, because cholinergic antagonists can impair cognitive performance (see…”
[FAB: a preliminar Spanish application of the frontal assessment battery to 11 groups of patients].
del Álamo, A. R., Alonso, M. J. C., & Marín, L. C. (2003) · PubMed · Cited by 31 · see citing works
Pessin, H., Rosenfeld, B. D., Burton, L. A., & BREITBART, W. S. (2003) · General Hospital Psychiatry · doi:10.1016/s0163-8343(03)00008-2 · Cited by 30 · see citing works
“, below 10 on the HIV-DS, 138 or below on the DRS, 26 or below on the MMSE) [23,29–30].”
BackgroundVerbal Learning and Memory in Older Adults with Minor and Major Depression
Mesholam‐Gately, R. I., Giuliano, A. J., Zillmer, E. A., Barakat, L. P., Kumar, A., Gur, R. C., McAndrew, L. M., Bilker, W. B., Elderkin‐Thompson, V., & Moberg, P. J. (2011) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr106 · Cited by 29 · see citing works
Buono, M. D., Busato, R., Mazzetto, M., Paccagnella, B., Aleotti, F., Zanetti, O. O., Bianchetti, A., Trabucchi, M., & Leo, D. D. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199911)14:11 · Cited by 65 · see citing works
Shafie, A., Ashour, A. A., Anwar, S., Anjum, F., & Hassan, M. I. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01499-w · Cited by 29 · see citing works
“Subcortical deficiencies account for most cognitive impairments associated with HD, including slow processing speed, inattentiveness, difficulty solving problems, and reduced memory recovery (Paulsen et al. 1995).”
Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease
Sherman, A. M., Jaeckle, K. A., & Meyers, C. A. (2002) · Cancer · doi:10.1002/cncr.10816 · Cited by 27 · see citing works
Cortical and Subcortical Dynamics of Aging with HIV Infection
Vance, D. E. (2004) · Perceptual and Motor Skills · doi:10.2466/pms.98.2.647-655 · Cited by 25 · see citing works
“I?, SWERDLOW, N. R., & SWENSON, M. R. (1995) Distinct cognitive profiles of cortical and subcortical dementia in advanced illness.”
BackgroundDAVIS, J., Filoteo, J. V., Kesner, R., & ROBERTS, J. (2003) · Cortex · doi:10.1016/s0010-9452(08)70107-2 · Cited by 22 · see citing works
Huntington's Disease and Related Disorders
Anderson, K. E. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.10.001 · Cited by 22 · see citing works
“Apathy is reported in over 50% of HD patients [52], and it has been shown to increase with duration of illness [55,56].”
BackgroundAnderson, K. E. (2011) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52014-2.00002-1 · Cited by 20 · see citing works
Verbal learning and memory in schizophrenic and Parkinson's disease patients
van Oostrom, I., Dollfus, S., Brazo, P., Abadie, P., Halbecq, I., Théry, S., & Marie, R. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(02)00302-5 · Cited by 20 · see citing works
“This ‘subcortical’ profile can be characterized by a prominent retrieval deficit with relatively spared recognition memory in the context of greater impairment in delayed recall(Paulsen et al., 1995a).”
BackgroundNormative Data for the Dementia Rating Scale-2 in the French-Quebec Population
Lavoie, M., Callahan, B. L., Belleville, S., Simard, M., Bier, N., Gagnon, L., Gagnon, J., Blanchet, S., Potvin, O., Hudon, C., et al. (2013) · The Clinical Neuropsychologist · doi:10.1080/13854046.2013.825010 · Cited by 19 · see citing works
Altered risk‐aversion and risk‐taking behaviour in patients with Alzheimer's disease
Ha, J., Kim, E.-J., Lim, S., et al. (2012) · Psychogeriatrics · doi:10.1111/j.1479-8301.2011.00396.x · Cited by 19 · see citing works
Holtzer, R., Burright, R. G., & Donovick, P. J. (2002) · Clinical Gerontologist · doi:10.1300/j018v24n03_09 · Cited by 18 · see citing works
Schizophrenia in late life: Aging effects on symptoms and course of illness.
Harvey, P. D. (2005) · American Psychological Association eBooks · doi:10.1037/10873-000 · Cited by 18 · see citing works
Simard, F., Monetta, L., Nagano‐Saito, A., & Monchi, O. (2011) · Brain and Language · doi:10.1016/j.bandl.2011.08.002 · Cited by 15 · see citing works
Memory Changes with Aging and Dementia
Harvey, P. D., & Mohs, R. C. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50007-x · Cited by 15 · see citing works
Corey‐Bloom, J., Gluhm, S., Herndon, A., et al. (2016) · Journal of Huntington s Disease · doi:10.3233/jhd-150175 · Cited by 14 · see citing works
Huntington’s Disease: Clinical Features and Routes to Therapy
Paulson, H. L., & Albin, R. L. (2011) · Europe PMC (PubMed Central) · Cited by 19 · see citing works
Sheppard, D. P., Pirogovsky‐Turk, E., Woods, S. P., et al. (2016) · Applied Neuropsychology Adult · doi:10.1080/23279095.2015.1125904 · Cited by 12 · see citing works
“The MDRS is a standardized, well-validated measure commonly used in HD (Paulsen et al., 1995).”
MethodPlank, A.-C., Canneva, F., Raber, K. A., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00011 · Cited by 10 · see citing works
“A progressive aggravation of memory deficits ends up in subcortical dementia syndrome, characterized by slower processing of information, decreased motivation, depression and personality changes (Paulsen et al., 1995).”
BackgroundThe Dementia Rating Scale (DRS) in the diagnosis of vascular dementia
Porto, C. S., Caramelli, P., & Nitríni, R. (2007) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642008dn10300010 · Cited by 9 · see citing works
Presentation and Clinical Management of Dementia
Bayer, A. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10052-2 · Cited by 9 · see citing works
Which Diagnostic Procedures in the Elderly? The Case of Late-Onset Huntington's Disease
Appollonio, I. M., Frisoni, G. B., Curtò, N. A., et al. (1997) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879701000108 · Cited by 9 · see citing works
Cognitive decline in Huntington’s disease in the Digitalized Arithmetic Task (DAT)
Lunven, M., Bagnou, J. H., Youssov, K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253064 · Cited by 8 · see citing works
“Surprisingly, despite extensive use in the 1980s and 1990s (see for example: [36,37]), MDRS (which assesses global cognitive function) is currently no longer really used with HD patients, presumably because of its difficult translation and its duration (on average 30 minutes in advanced stages).”
BackgroundTranslational Approach using Advanced Therapy Medicinal Products for Huntington's Disease
Mousavi, M. A., Rezaei, M., Pourhamzeh, M., Salari, M., Hossein‐Khannazer, N., Shpichka, A. I., Nabavi, S. M., Timashev, P. S., & Vosough, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328300166240510071548 · Cited by 6 · see citing works
Qian, S., Chen, K., Guan, Q., et al. (2021) · BMC Neurology · doi:10.1186/s12883-021-02173-0 · Cited by 6 · see citing works
The influence of schooling on performance in the Mattis Dementia Rating Scale (DRS)
Porto, C. S., Caramelli, P., & Nitríni, R. (2010) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642010dn40200009 · Cited by 5 · see citing works
“DRS N GRSC 1 (1-4) GRSC 2 (5-8) GRSC 3 (9-11) GRSC 4 (>11)”
Visual-Spatial Memory and Recall Test (V-SMART): validity and reliability
Vik, P. W., Legarreta, M. D., & Riffel, S. (2017) · The Clinical Neuropsychologist · doi:10.1080/13854046.2017.1380845 · Cited by 4 · see citing works
“For example, a CVLT-II profile based on learning (Trials 1–5), intrusion errors on cued recall, and the difference between recognition discriminability and Trial 5 can reveal a subcortical disorder (e.g. Massman, Delis, Butters, Dupont, & Gillin, 1992; Paulsen et al., 1995).”
BackgroundHuntington’s Disease and Neurodegeneration
Heinz, A., Nabariya, D. K., & Krauß, S. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_226 · Cited by 3 · see citing works
Evaluation of Demyelinating and Degenerative Disorders
Allen, D. N., Sprenkel, D. G., Heyman, R. A., Schramke, C. J., & Heffron, N. E. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1950-2_9 · Cited by 4 · see citing works
Yıldız, E. (2025) · BMJ Supportive & Palliative Care · doi:10.1136/spcare-2025-005441 · Cited by 2 · see citing works
“21 Paulsen et al (1995) linked dementia and neuropsychiatry.”
Huntington’s Disease and Neurodegeneration
Heinz, A., Nabariya, D. K., & Krauß, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_226-1 · Cited by 2 · see citing works
Cognitive impairment in patients with Parkinson’s disease: profiles and implications for prognosis
Janvin, C. C. (2007) · NORA - Norwegian Open Research Archives · Cited by 2 · see citing works
Posttraumatic growth in Huntington disease
O’Rourke, J. J. F. (2011) · doi:10.17077/etd.1frg77hf · Cited by 2 · see citing works
“Cognitive declines in HD fit a prototypical subcortical dementia well (Morris, 1995; Paulsen et al., 1995).”
BackgroundTHE ABILITY TO COMPREHEND AFFECTIVE COMMUNICATION IN INDIVIDUALS WITH Huntington's Disease
Seidman-Carlson, R., & Wells, D. L. (1998) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-19981201-06 · Cited by 2 · see citing works
Sugarman, M. A., Jacobs, D. R., Paulson, D. L., et al. (2013) · Journal of Intellectual & Developmental Disability · doi:10.3109/13668250.2013.870330 · Cited by 1 · see citing works
“Multiple studies (Paulsen et al., 1995; Salmon, Kwo-on-Yuen, Heindel, Butters, & Thal, 1989) have observed that low Initiation/Perseveration scores could reliably discriminate patients with Huntington’s disease from those with Alzheimer’s disease (who were characterised by low Memory scores).”
BackgroundResultCuturic, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-38606-1_8 · Cited by 1 · see citing works
Silva, S. R., de Resende–Neto, A. G., Vasconcelos, A. B. S., Monteiro, M. R. P., Pantoja-Cardoso, A., Santos, L. E. S., Lima, N. B. C., Santos, J., Aragão-Santos, J. C., Schimieguel, D. M., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1638590 · Cited by 2 · see citing works
Huntington’s Disease Case Study
Sanders, K. M., & Burdick, D. J. (2019) · Springer eBooks · doi:10.1007/978-1-4939-8722-1_19 · Cited by 1 · see citing works
Estudio normativo de la Dementia Rating Scale-2 en una muestra poblacional española mayor de 60 años
Liz, L. G. (2010) · doi:10.14201/gredos.76483 · Cited by 1 · see citing works
Repeat expansion diseases and dementia
Dayalu, P., Albin, R. L., & Paulson, H. L. (2016) · doi:10.1002/9781118797662.ch8 · Cited by 1 · see citing works
Rinne, J. O., Elovaara, I., & Alafuzoff, I. I. (2003) · doi:10.1002/9780470752340.ch23
Multiple sclerosis: a subcortical, white matter dementia?
Feinstein, A. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543760.013
Aberrant chloride homeostasis and inhibitory synaptic transmission in Huntington's disease
Dargaei, Z. (2018) · TSpace (University of Toronto)
Anderson, K. E., & Marder, K. S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-960-8_18
Duff, K. M., & Paulsen, J. S. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7506-7525-3.50047-9
Self-citationApathy in Parkinson’s disease. A community-based study
Pedersen, K. F. (2010) · NORA - Norwegian Open Research Archives
Qian, S., Chen, K., Guan, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14462589
Hobbs, D. A. (2015) · ScholarWorks @ The University of New Orleans (The University of New Orleans)
- Authors
- Paulsen, J. S., Butters, N., Sadek, J. R., Johnson, S. A., Salmon, D. P., Swerdlow, N. R., & Swenson, M. R.
- Affiliations
- University of California San Diego (US)
- Venue
- Neurology
- Published
- 1995-05
- Volume
- 45
- Issue
- 5
- Pages
- 951-956
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2168450537
- Cited by
- 97
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01mh045131-06a1)
- National Institute on Aging (AG05131, P50AG005131)
- National Institute of Mental Health (MH49671-03, P30MH049671, MH45131-06)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- Huntington's disease, Alzheimer's disease, dementia severity, cognitive profile, cortical dementia, subcortical dementia, Mattis Dementia Rating Scale, memory impairment, constructional praxis, advanced disease
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Cognition, Dementia, Humans, Huntington Disease, Middle Aged, Psychiatric Status Rating Scales
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
