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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The spectrum of behavioral changes in Alzheimer's disease

Mega, Michael S., Cummings, Jeffrey L., Fiorello, Tara, Gornbein, Jeffrey·1996·Neurology
DOI 10.1212/wnl.46.1.130
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Abstract

We investigated the range of behavioral abnormalities in patients with Alzheimer's disease (AD) compared with normal age-matched control subjects. The range of behavioral disturbances manifested and the relationship between specific abnormalities with the level of cognitive impairment have not been established. Fifty consecutive outpatients with mild (n = 17), moderate (n = 20), and severe (n = 13) AD and 40 age-matched normal controls were evaluated for behavioral abnormalities occurring in the month preceding the interview. The caregivers of the patients and the spouses of the control subjects were interviewed with the Neuropsychiatric Inventory (NPI). The frequency and severity of the following 10 behaviors were assessed: delusions, hallucinations, agitation, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability, and aberrant motor behavior. Correlations among these 10 behaviors and their relationship with cognitive impairment were also investigated. Eighty-eight percent of AD patients had measurable behavioral changes. All 10 behaviors were significantly increased in the AD patients compared with normal subjects. The most common behavior was apathy, which was exhibited by 72% of patients, followed by agitation (60%), anxiety (48%), irritability (42%), dysphoria and aberrant motor behavior (both 38%), disinhibition (36%), delusions (22%), and hallucinations (10%). Agitation, dysphoria, apathy, and aberrant motor behavior were significantly correlated wit cognitive impairment.

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Research works printed but not linked: 46

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Metadata

Authors
Mega, M. S., Cummings, J. L., Fiorello, T., & Gornbein, J.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-01
Volume
46
Issue
1
Pages
130-135
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.46.1.130
OpenAlex
W2124214624
Cited by
1,115
References
3
FWCI
20.34
Type
journal article
Language
en
Open access
closed

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Mega, M. S., Cummings, J. L., Fiorello, T., & Gornbein, J. (1996). The spectrum of behavioral changes in Alzheimer's disease. Neurology. https://doi.org/10.1212/wnl.46.1.130

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