Cited by 346Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Apolipoprotein E element 4 association with dementia in a population-based study: The Framingham Study

Myers, R. H., Schaefer, E. J., Wilson, P.W.F., D'Agostino, R., Ordovas, J. M., Espino, A., Au, R., White, R. F., Knoefel, J. E., Cobb, J. L., McNulty, K. A., Beiser, A., Wolf, P. A.·1996·Neurology

DOI 10.1212/wnl.46.3.673

Open this paper in CoChat — free account

Abstract

Apolipoprotein E type 4 allele (apoE epsilon4) is associated with Alzheimer's disease (AD) in the late-onset familial form and in sporadic cases, but the age-associated risk in a randomly sampled elderly population is not established. We examined the association of apoE epsilon4 with AD and other dementias (mainly multi-infarct or dementia following stroke) in 1,030 persons aged 71 to 100 years in the population-based Framingham Study cohort. Kaplan-Meier survival analysis revealed that 55% of the apoE epsilon4/epsilon4 homozygotes developed AD by age 80, whereas 27% of apoE epsilon3/epsilon4 heterozygotes developed AD by age 85, and 9% of those without a 4 allele developed AD by age 85 years. In comparison with persons without a 4 allele, the risk ration for AD was 3.7 (95% CI = 1.9 to 7.5) for apoE epsilon3/epsilon4 heterozygotes and 30.1 (95% CI = 10.7 to 84.4) for apoE epsilon4 homozygotes. ApoE epsilon2 (2/2, 2/3, or 2/4 genotypes) was associated with an absence of AD. One-half (n=21) of the 43 AD patients were either homozygous or heterozygous for apoE epsilon4. We found evidence for an association of apoE epsilon4 with other dementia, primarily multi-infarct dementia and stroke. The risk ratio was 2.3 (95% CI = 0.9 to 6.1) for non-AD dementias among persons with apoE epsilon3/epsilon4. Although the apoE epsilon4 allele is a potent risk factor for AD and may be associated with other forms of dementia, most apoE epsilon4 carriers do not develop dementia, and about one-ha…

Integrity signals

Registry

Crossref · 10.1212/wnl.46.3.673

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
The Framingham Study
Dawber, T. R. (1980) · Harvard University Press eBooks · doi:10.4159/harvard.9780674492097 · Cited by 1,965
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,639
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363
Cyclic guanosine monophosphate as a mediator of vasodilation.
Murad, F. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112536 · Cited by 799
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
(1991) · Europe PMC (PubMed Central) · Cited by 758
Neurosurgical horizons in Parkinson's disease
Goetz, C. G., Long, M. R. D., Penn, R. D., & Bakay, R. A. E. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.1 · Cited by 405
Megadose corticosteroids in multiple sclerosis
Kupersmith, M. J., Kaufman, D., Paty, D. W., Ebers, G. C., McFarland, H., Johnson, K., Reingold, S. C., & Whitaker, J. N. (1994) · Neurology · doi:10.1212/wnl.44.1.1 · Cited by 386
Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality
Ross, D. A., Dollimore, N., Smith, P. G., Kirkwood, B. R., Arthur, P., Morris, S. S., Addy, H. A., Binka, F., Arthur, P., Gyapong, J. O., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)91879-q · Cited by 384

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 12

Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein element 4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.
Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotype with late-onset Alzheimer's disease: population-based study. BMJ 1994;309:636-638.
Bachman DL, Wolf PA, Linn RT, et al. Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology 1993;43:515-519.
Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res 1990;31:545-548.
Utterman G. Apolipoprotein E polymorphism in health and disease. Am Heart J 1987;113:433-440.
10.1016/0140-6736(93)91879-Q · DOI
10.1016/0140-6736(93)91878-P · DOI
Myers RH Schaefer EJ Wilson PWF et al. Apolipoprotein E allele 4 is associated with dementia in the Framingham Study. In: Iqbal K Mortimer J Winblad B Wisniewski H eds. Research advances in Alzheimer's disease and related disorders. John Wiley & Sons Ltd. Chichester England: 1995:63-70.
van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E2 allele is associated with an increased risk of earlyonset Alzheimer's disease and a reduced survival. Ann Neurol 1995;37:605-610.
St. Clair D, Norrman J, Perry R, Yates C, Wilcock G, Brookes A. Apolipoprotein E element 4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls. Neurosci Lett 1994;176:45-46.
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-944.
10.1212/WNL.45.1.1 · DOI

Sorted by citations

Items 201–300 of 346

Interaction of Alzheimer’s Disease-Associated Genetic Risk with Indicators of Socioeconomic Position on Mild Cognitive Impairment in the Heinz Nixdorf Recall Study
Frank, M., Hensel, J., Baak, L., Schramm, S. H., Dragano, N., Weimar, C., Hoffmann, P., Nöthen, M. M., Erbel, R., Jöckel, K., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210244 · Cited by 16
Interaction of Apolipoprotein E ε 4 With Other Genetic and Non-Genetic Risk Factors in Late Onset Alzheimer Disease: Problems Facing the Investigator
Katzman, R., Kang, D. E., & Thomas, R. G. (1998) · Neurochemical Research · doi:10.1023/a:1022461601609 · Cited by 16
Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
Arbeev, K. G., Ukraintseva, S. V., Kulminski, A. M., Akushevich, I. V., Arbeeva, L. S., Culminskaya, I. V., Wu, D., & Yashin, A. I. (2012) · Scientifica · doi:10.6064/2012/568628 · Cited by 15
Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project
Nakahata, N., Nakamura, T., Kawarabayashi, T., Seino, Y., Ichii, S., Ikeda, Y., Amari, M., Takatama, M., Murashita, K., Ihara, K., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210699 · Cited by 14
APOE ε2 and ε4 influence the susceptibility for Alzheimer's disease but not other dementias.
Lovati, C., Galimberti, D., Albani, D., Bertora, P., Venturelli, E., Cislaghi, G., Guidi, I., Fenoglio, C., Cortini, F., Clerici, F., et al. (2010) · PubMed Central · Cited by 15
Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations
Sudo, S., Shiozawa, M., Cairns, N. J., & Wada, Y. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.043 · Cited by 15
Pharmacologic Management of Alzheimer Disease Part I: Hormonal and Emerging Investigational Drug Therapies
Flynn, B. L. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.16378 · Cited by 15
Sensitivity and specificity of three clinical criteria for dementia with Lewy bodies in an autopsy-verified sample
Luis, C. A., Barker, W., Gajaraj, K., Harwood, D. G., Petersen, R., Kashuba, A., Waters, C., Jimison, P., Pearl, G. S., Petito, C. K., et al. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199907)14:7 · Cited by 140
A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus
Wang, Z., Miki, T., Ding, Y., Wang, S., Gao, Y., Wang, X., Wang, Y., YOKOYAMA, T., Warita, K., Ohta, K., et al. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9252-z · Cited by 12
Lipids and Vascular Disease: A Framingham Perspective
Wilson, P. W. F. (2013) · Global Heart · doi:10.1016/j.gheart.2012.12.009 · Cited by 15
Self-citation
Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury
Pase, M. P., Beiser, A., Aparicio, H. J., DeCarli, C. S., Vasan, R. S., Murabito, J. M., & Seshadri, S. S. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.09.006 · Cited by 14
Self-citation
Identification, expression and function of apolipoprotein E in annual fish Nothobranchius guentheri: implication for an aging marker
Wang, X., Shang, X., Luan, J. Y., & Zhang, S. (2014) · Biogerontology · doi:10.1007/s10522-014-9493-4 · Cited by 14
Measuring Study-Specific Heterogeneity in Meta-Analysis: Application to an Antecedent Biomarker Study of Alzheimer’s Disease
Xiong, C., Miller, J. P., & Morris, J. C. (2010) · Statistics in Biopharmaceutical Research · doi:10.1198/sbr.2009.0067 · Cited by 13
Associations between apolipoprotein E gene polymorphisms and Alzheimer’s disease risk in a large Chinese Han population
Sun, Y., Wu, P., Li, H., Liu, Z., Tao, Q., Guo, Q., Hong, Z., & Xu, M. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s73396 · Cited by 14
ApoE Genotype and Family History in Patients With Dementia and Cognitively Intact Spousal Controls
Zintl, M., Schmitz, G., Hajak, G., & Klünemann, H.-H. (2009) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317509333040 · Cited by 14
Genetic Prediction: What are the Limits?
Wilkie, A. O. M. (2001) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/s1369-8486(01)00028-0 · Cited by 14
Bridges to Life
Kurzweil, R., & Grossman, T. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_1 · Cited by 14
A Multistate Model of the Genetic Risk of Alzheimer's Disease
Ewbank, D. C. (2002) · Experimental Aging Research · doi:10.1080/03610730290103096 · Cited by 13
Medical utility of apoe allele determination in assessing the need for antioxidant therapy
Dreon, D. M., & Peroutkal, S. J. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1213 · Cited by 13
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study
Keage, H. A. D., Matthews, F. E., Yip, A. G., Gao, L., McCracken, C., McKeith, I. G., Rubinsztein, D. C., Brayne, C., & Study, M. C. F. A. A. (2009) · Age and Ageing · doi:10.1093/ageing/afp210 · Cited by 13
Diagnosis, Classification and Natural History of Degenerative Dementias
Feldman, H., & Kertesz, A. (2001) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100001177 · Cited by 14
Preventing Dementia
Black, S. E., Patterson, C., & Feightner, J. (2001) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100001219 · Cited by 13
Effect of apolipoprotein E status on clinical features of dementia
Burlinson, S., Burns, A. S., Mann, D. M. A., Pickering-Brown, S. M., & Owen, F. (1998) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199803)13:3 · Cited by 12
The value of genotyping for apolipoprotein E alleles in relation to vitamin E supplementation
Peroutka, S. J., & Dreon, D. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00813-x · Cited by 13
Apolipoprotein E Polymorphism in Alzheimer’s Disease: A Comparative Study of Two Research Populations from Spain and the United States
López, O. L., Pousa, S. L., Kamboh, M. I., Adroer, R., Oliva, R., Gallego, M. L., Becker, J. T., & DeKosky, S. T. (1998) · European Neurology · doi:10.1159/000007939 · Cited by 13
The Potential Effect of Caffeine and Nicotine Co-administration against Aluminum-induced Alzheimer's disease in Rats
Ali, A. A., & Ahmed, H. I. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000236 · Cited by 13
ApoE allelic variability influences pupil response to cholinergic challenge and cognitive impairment
Scinto, L. F. M. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00247.x · Cited by 12
Associations of Apolipoprotein E Concentration and Polymorphism with Lipids and Apolipoprotein Levels in Chinese from Beijing and Shanghai
Xia, Y., Sass, C., Shen, X., Siest, G., & Visvikis‐Siest, S. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.094 · Cited by 12
Risk Factors for Alzheimer's Disease: An Overview for Clinical Practitioners
Kim, K. Y., Wood, B. E., & Wilson, M. I. (2005) · The Consultant Pharmacist · doi:10.4140/tcp.n.2005.224 · Cited by 12
Clinical rationale of genetic testing in dementia.
Frisoni, G. B., & Trabucchi, M. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.217 · Cited by 12
Type 2 diabetes and late-onset Alzheimer’s disease and related dementia: A longitudinal cohort study integrating polygenic risk score
Jeong, S., Lin, L., Pascual‐Leone, Á., & Hsu, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251326107 · Cited by 13
Enfermedad de Alzheimer
Merino, E. N., Sendín, M. A. C., & Osorio, J. A. V. (2015) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2015.01.002 · Cited by 14
Innovative Research Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults
Etnier, J. L., Labban, J. D., Karper, W. B., Wideman, L., Piepmeier, A. T., Shih, C.-H., Castellano, M., Williams, L. M., Park, S.-Y., Henrich, V. C., et al. (2015) · Journal of Aging and Physical Activity · doi:10.1123/japa.2014-0221 · Cited by 12
From Genetics to Postgenomics and the Discovery of the New Social Body
Lock, M. M. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-009 · Cited by 12
Relationships between Cerebrovascular Events, APOE Polymorphism and Alzheimer’s Disease in a Community Sample
Johnston, J. M., Nazar‐Stewart, V., Kelsey, S. F., Kamboh, M. I., & Ganguli, M. (2000) · Neuroepidemiology · doi:10.1159/000026271 · Cited by 11
THE GENETICS OF DEMENTIA IN LATE LIFE
Plassman, B. L., & Breitner, J. C. S. (1997) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70393-2 · Cited by 11
Genetic Testing for Alzheimer Disease
Tracy, K. B. (1997) · JAMA · doi:10.1001/jama.1997.03550120038022 · Cited by 11
Reply
Hyman, B. T., & Wallace, R. B. (1997) · Annals of Neurology · doi:10.1002/ana.410410323 · Cited by 11
Plasma Concentrations of the Amyloid-β Peptides in Young Volunteers: The Influence of the APOE Genotype
Zimmermann, R., Huber, E., Schamber, C., Lelental, N., Mroczko, B., Brandner, S., Maler, J. M., Oberstein, T. J., Szmitkowski, M., Rauh, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132687 · Cited by 10
Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
Maynard, S., & Gelblum, J. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s49895 · Cited by 11
Citalopram for the Treatment of Agitation in Alzheimer Dementia
Peters, M. E., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S. S., Shade, D. M., et al. (2015) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988715601735 · Cited by 13
Polimorfismos en el gen de la apolipoproteína E y riesgo de hipercolesterolemia: un estudio de casos y controles en una población laboral de Valencia
Corella, D., Guillén, M., Portolés, O., Martínez‐Sabater, A., Cortina, S. H. M., Folch, J., & Sáiz, C. (2000) · Medicina Clínica · doi:10.1016/s0025-7753(00)71498-9 · Cited by 9
Some Remarks on Biological Markers of Alzheimer’s Disease
Robles, A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00011-6 · Cited by 9
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies
Kulminski, A. M., Culminskaya, I. V., Arbeev, K. G., Arbeeva, L. S., Ukraintseva, S. V., Stallard, E., Wu, D., & Yashin, A. I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136319 · Cited by 9
Influence of plasma cytokine levels on the conversion risk from MCI to dementia in the Alzheimer's disease neuroimaging initiative database
Abe, K., Chiba, Y., Hattori, S., Tamazawa, A., Yoshimi, A., Katsuse, O., & Suda, A. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116829 · Cited by 9
A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
White, D., John, C. S., Kucera, A., Truver, B., Lepping, R. J., Kueck, P. J., Lee, P., Martin, L. E., Billinger, S. A., Burns, J. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92177-0 · Cited by 10
Grafting Together Medical Anthropology, Feminism, and Technoscience
Martin, E. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-003 · Cited by 9
GERIATRIC BIOSCIENCE: Apolipoprotein E Genotype: Utility in Clinical Practice in Alzheimer's Disease
Hyman, B. T. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb04073.x · Cited by 9
Using a murine model to explore the impact of sex and APOE4 on cisplatin-induced cognitive impairment
Fowler, C. G., Tarantino, M. I., Gillett, A. E., Muñiz, V., Anderson, M. A., Bonner, R. L., & Vichaya, E. G. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.05.010 · Cited by 8
Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimer's Disease
Ma, S. L., & LAM, L. C. W. (2011) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2011.9.2.54 · Cited by 8
Plasma MMP-9 Levels as the Future Risk of Conversion to Dementia in ApoE4-Positive MCI Patients: Investigation Based on the Alzheimer's Disease Neuroimaging Initiative Database
Abe, K., Chiba, Y., Ide, K., Yoshimi, A., Asami, T., Suda, A., Odawara, T., & Hishimoto, A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.19 · Cited by 9
Recent advances in molecular genetics of cardiovascular disorders
Schmitz, G., Aslanidis, C., & Lackner, K. J. (1998) · Pathology & Oncology Research · doi:10.1007/bf02904710 · Cited by 8
Lipid Metabolism and Oxidation in Neurons and Glial Cells
Fantini, J., & Yahi, N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800111-0.00003-5 · Cited by 7
Facteurs de risque et facteurs protecteurs des démences
Clément, J. (2007) · Morphologie · doi:10.1016/j.morpho.2007.12.002 · Cited by 7
Apolipoprotein E Pittsburgh variant is not associated with the risk of late‐onset Alzheimer's disease in a Spanish population
Baron, M., Jimenez‐Escrig, A., Orensanz, L., Simon, J., & Perez‐Tur, J. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20028 · Cited by 7
Preexisting dementia is associated with higher mortality rate in patients with femoral neck fracture
Rajeev, A. S., Ali, M., Tuinebreijer, W. E., Zourob, E., & Anto, J. (2021) · Aging Medicine · doi:10.1002/agm2.12142 · Cited by 7
Apolipoprotein E genotype and cognition in the very old
Altstiel, L., Greenberg, D. A., Marin, D. B., Lantz, M., & Mohs, R. C. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63728-2 · Cited by 7
Efecto del polimorfismo de la apolipoproteína E en el perfil lipoproteico y riesgo cardiovascular en una población mediterránea
Sorlí, J. V., Velert, R., Guillén, M., Portolés, O., Sabio, J. B. R., Iborra, J. R., & Corella, D. (2002) · Medicina Clínica · doi:10.1016/s0025-7753(02)72454-8 · Cited by 8
Molecular genetics of early-onset Alzheimer's disease and frontotemporal lobar degeneration
Krüger, J. (2010) · Cited by 7
Dementia and genetics.
Williams, J. H. (2003) · American Psychological Association eBooks · doi:10.1037/10480-025 · Cited by 7
Ultra-Early Screening of Cognitive Decline Due to Alzheimer’s Pathology
Wei, P. (2023) · Biomedicines · doi:10.3390/biomedicines11051423 · Cited by 7
Association of Blood Lipoprotein Levels With Incident Alzheimer Disease in Community-Dwelling Individuals
Charisis, S., Lu, S., Melgarejo, J. D., Satizábal, C. L., Vasan, R. S., Beiser, A., & Seshadri, S. S. (2025) · Neurology · doi:10.1212/wnl.0000000000213715 · Cited by 6
Self-citation
Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers
Kadey, K. R., Woodard, J. L., Moll, A. C., Nielson, K. A., Smith, J. C., Durgerian, S., & Rao, S. M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201360 · Cited by 6
Ursachen und Behandlungskonzepte der Demenzen
Förstl, H., Lauter, H. J., & Bickel, H. (2001) · VS Verlag für Sozialwissenschaften eBooks · doi:10.1007/978-3-322-99712-8_4 · Cited by 6
C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
Gutiérrez-Hermosillo, H., de León‐González, E. D., Palacios‐Corona, R., Cedillo-Rodríguez, J. A., Camacho‐Luis, A., Reyes-Romero, M. A., Medina-Chávez, J. H., & Blandón, P. A. (2013) · Medicina Clínica · doi:10.1016/j.medcli.2013.09.035 · Cited by 6
Genetics and Dementia Nosology
Blacker, D., & Lovestone, S. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706291091 · Cited by 6
A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementiaPreprint
Fongang, B., Sargurupremraj, M., Jian, X., Mishra, A., Damotte, V., Bis, J. C., Kang-Hsien, F., Li, G., Yang, J., Hilal, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.11.509802 · Cited by 6
Insulin Resistance and Oligodendrocyte/Microvascular Endothelial Cell Dysfunction as Mediators of White Matter Degeneration in Alzheimer’s Disease
de la Monte, S. M., & Grammas, P. (2019) · Codon Publications eBooks · doi:10.15586/alzheimersdisease.2019.ch8 · Cited by 7
Sphingolipids in Cerebrospinal Fluid and Plasma Lipoproteins of APOE4 Homozygotes and Non- APOE4 Carriers with Mild Cognitive Impairment versus Subjective Cognitive Decline
den Hoedt, S., Dorst‐Lagerwerf, K. Y., de Vries, H. E., Rozemüller, A. J. M., Scheltens, P., Walter, J., Sijbrands, E. J. G., Martínez‐Martínez, P., Verhoeven, A. J. M., Teunissen, C. E., et al. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr220072 · Cited by 4
The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease
Çinleti, B. A., YARDIMCI, N., Aytürk, Z., İlhan, A., Kaya, G., Acar, M., Koç, E. R., Gündüz, E., & Gündüz, M. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1407-19 · Cited by 4
Making Peasants Protestant and Other Projects
Cohen, L. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-005 · Cited by 4
Diagnosis, risk factors, and treatment of vascular dementia
López, O. L., Kuller, L. H., & Becker, J. T. (2004) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-004-0082-9 · Cited by 4
Clinical features and alterations in the inferior horn sizes in lateral ventricle in Alzheimer's patients with different ApoE genotype in Japanese population
Yoshida, S., Iwabuchi, Y., Numachi, Y., Saito, H., Yamazaki, H., Sakai, H., Kimura, M., Matsuoka, H., & Sato, M. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00199-3 · Cited by 4
Sad but true: your father has dementia. An approach to announcing the diagnosis.
Frenette, G., & Beauchemin, J. (2003) · PubMed Central · Cited by 4
The Essentials of Biochemistry of the Proteins as Related to Alzheimer’s Disease: A Review
Prasad, A. (2020) · International Journal of Biochemistry Research & Review · doi:10.9734/ijbcrr/2020/v29i130163 · Cited by 4
PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR DEMENTIA AND ALZHEIMER'S DISEASE
Eshadri, S. U. S., Eiser, A. L. B., Elhub, J. A. S., Aul, P., Acques, F. J., Osenberg, I. R. H. R., Eter, P., & Olf, P. H. A. W. (2002) · Cited by 4
Genetic Risk Factors for Dementia
Hollingworth, P., & Williams, J. H. (2011) · Wiley eBooks · doi:10.1002/9781444344110.ch6 · Cited by 4
Susceptibility Genetics in the Etiopathogenesis of Alzheimer's Disease:Role for Potential Confounding Factors
Harrington, C. R., & Roth, M. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004390 · Cited by 3
Family History of Dementia and Current Depression in Nondemented Community-Dwelling Older Adults
Harwood, D. G., Barker, W., Ownby, R. L., MULLAN, M. J., & Duara, R. (2000) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870001300204 · Cited by 4
Exploratory Data Analysis in a Six-Year Longitudinal Study in Healthy Brain AgingPreprint
Gómez-Ramírez, J., Ávila‐Villanueva, M., Payo, B. F., Quijano, T. D. S., Soler, M. V., Sevilla, M. A. Z., & Fernández‐Blázquez, M. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/674853 · Cited by 4
INTRODUCTION:
Inhorn, M. C., & WENTZELL, E. A. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-001 · Cited by 4
Beyond Structure: The Interplay of Bone and Brain During Alzheimer's Disease
Pinnamaneni, A., Akkiraju, A., Park, H. I., Ch, R. S. R., V, Ayalasomayajula, V., Bandela, M., Kaipa, S., Khosla, S., Zeineh, M., & Suryadevara, V. (2025) · Comprehensive Physiology · doi:10.1002/cph4.70075 · Cited by 2
Medical Anthropology and Public Policy
Singers, M. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-012 · Cited by 5
Incidence and Cognitive Decline of Alzheimer’s Disease and Other Dementia by Apolipoprotein ε4 Allele Presence: A Community-Based Cohort Study in Korean Elderly
Yoo, S. Y., Han, A. L., Park, S., & Lee, J.-Y. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0347 · Cited by 4
Artificial intelligence for risk prediction of Alzheimer's disease
Ganasegeran, K., Ch’ng, A. S. H., & Looi, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822271-3.00010-4 · Cited by 3
Dementias
Domoto‐Reilly, K., Flanagan, M. E., & Grabowski, T. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-03283-8_6 · Cited by 3
Towards defining the Mechanisms of Alzheimer's disease based on a contextual analysis of molecular pathways
Richens, J. L., Bramble, J. P., Spencer, H. L., Cantlay, F., Butler, M., & O’Shea, P. (2016) · Global Medical Genetics · doi:10.3934/genet.2016.1.25 · Cited by 3
Parkinsonism-Plus Syndromes and Secondary Parkinsonian Disorders
Fahn, S., Jankovic, J. J., Hallett, M., & Jenner, P. G. (2007) · Elsevier eBooks · doi:10.1016/b978-0-443-07941-2.50013-9 · Cited by 3
Critical Intersections and Engagements
Parker, R. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-013 · Cited by 3
Cognitive Impairment and Rehabilitation in Alzheimer’s Disease
Angelopoulos, T., Scordilis, D. M., & Tsagkaris, C. (2019) · Springer eBooks · doi:10.1007/978-981-13-9636-6_1 · Cited by 3
Genetic Testing in the Early Diagnosis of Alzheimer’s Disease
Blacker, D., & Tanzi, R. E. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-005-6_5 · Cited by 3
Genomic insights into the etiology of Alzheimer's disease: a review
Reitz (2014) · Advances in Genomics and Genetics · doi:10.2147/agg.s51293 · Cited by 2
Association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in individuals 65 years or more with diabetes from a Geriatric Service in Monterrey, Mexico
de León‐González, E. D., Hermosillo, H. G., Rodrígez, J. A. C., Romero, M. A. R., Camacho‐Luis, A., Corona, R. P., Nava, J. A. B., Valles, J. A. R., & Pérez, H. E. T. (2013) · Medicina Clínica · doi:10.1016/j.medcli.2013.07.031 · Cited by 2
Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00009-3 · Cited by 2
An AS‐qPCR‐based method for the detection of Alzheimer's disease‐related SNPs
Chen, J., Shi, B., Li, Y., Feng, Y., Ni, J., Shi, J., Luo, C., Wang, J., & Tian, J. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30350 · Cited by 2
Measuring Overall Heterogeneity in Meta-Analyses: Application to CSF Biomarker Studies in Alzheimer’s Disease
Xiong, C., Gao, F., Yan, Y., Luo, J. R., Sung, Y., & Shi, G. (2008) · Journal of Modern Applied Statistical Methods · doi:10.22237/jmasm/1209615780 · Cited by 2
Interplay Between 3D Chromatin Architecture and Gene Regulation at the APOE Locus Contributes to Alzheimer’s Disease Risk
Lee, E.-G., Leong, L., Chen, S., Tulloch, J., & Yu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010302 · Cited by 1
The Complex Role of Genes in Diseases and Traits in Late Life: An Example of the Apolipoprotein E Polymorphism
Kulminski, A. M., Yashin, A. I., Culminskaya, I. V., Land, K. C., & Ukraintseva, S. V. (2016) · The Springer series on demographic methods and population analysis · doi:10.1007/978-94-017-7587-8_9 · Cited by 1
Getting at Anthropology through Medical History
Morgan, L. M. (2012) · Duke University Press eBooks · doi:10.1215/9780822395478-004 · Cited by 1
Risk Assessment for Complications of Diabetes Mellitus
(2009) · CRC Press eBooks · doi:10.1201/9781420079364.ch5 · Cited by 1

Authors: Myers, R. H., Schaefer, E. J., Wilson, P. W. F., D'Agostino, R., Ordovas, J. M., Espino, A., Au, R., White, R. F., Knoefel, J. E., Cobb, J. L., McNulty, K. A., Beiser, A., & Wolf, P. A.
Affiliations: Boston University (US)
ORCID: Myers, R. H.
Schaefer, E. J.
Wilson, P.W.F.
Au, R.
White, R. F.
Knoefel, J. E.
Beiser, A.
Wolf, P. A.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-03
Volume: 46
Issue: 3
Pages: 673-677
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.46.3.673
OpenAlex: W1972509050
Cited by: 346
References: 30
Citations by year: 2026: 2 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 10 · 2021: 12 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 13 · 2014: 11 · 2013: 16 · 2012: 24
FWCI: 16.71
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc038038-022)
National Institute on Aging (2-R01-AG08122-06, R01AG008122)
National Heart, Lung, and Blood Institute (N01-HC-38038)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: APOE ε4, Alzheimer's disease, dementia, multi-infarct dementia, stroke, genetic risk factors, APOE genotype, Framingham Heart Study, older adults, positive predictive value, genetic screening
MeSH terms: Adult, Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Base Sequence, Dementia, Female, Humans, Longitudinal Studies, Male, Middle Aged, Molecular Sequence Data, Sensitivity and Specificity, Cohort Studies, Molecular Probes, Incidence, Odds Ratio, Apolipoprotein E4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Apolipoprotein E element 4 association with dementia in a population-based study: The Framingham Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks