The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV
Abstract
We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2) High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
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“There is strong experimental evidence that the APOE isoforms are major determinants of the amount and quality of amyloid-β peptide (Aβ) and amyloid burden in the brain that develops during aging.15–17”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [16]
In the citing paper
“Atherosclerosis has been associated with AD and cerebral angiopathy in humans [43], [44], and recent findings indicate that vascular risk factors and neurovascular dysfunction play integral roles in the pathogenesis of AD [45].”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [44]
In the citing paper
“Neuropathological examination of patient brains harboring APP duplications show abundant plaque and tangle pathology as well cerebral amyloid angiopathy (CAA)”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [249]
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Metadata
- Authors
- Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A.
- Affiliations
- University of California San Diego (US)
- Emory University (US)
- Washington University in St. Louis (US)
- University of Washington (US)
- Duke University (US)
- Venue
- Neurology
- Published
- 1996-06
- Volume
- 46
- Issue
- 6
- Pages
- 1592-1596
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2020068741
- Cited by
- 561
- References
- 26
- Citations by year
- 2026: 5 · 2025: 26 · 2024: 18 · 2023: 10 · 2022: 20 · 2021: 38 · 2020: 32 · 2019: 23 · 2018: 17 · 2017: 26 · 2016: 27 · 2015: 30 · 2014: 20 · 2013: 23 · 2012: 17
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Agricultural Sciences
- National Institute on Aging (AG06790, AG05131, P50AG005131, U01AG006790)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cerebral amyloid angiopathy, Alzheimer's disease, intracerebral hemorrhage, ischemic lesions, cerebral arteriosclerosis, atherosclerosis, vascular pathology
- MeSH terms
- Aged, Alzheimer Disease, Arteriosclerosis, Brain, Cerebral Hemorrhage, Brain Ischemia, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, United States, Comorbidity, Cerebral Amyloid Angiopathy
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