Cited by 561Intracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., Heyman, A.·1996·Neurology

DOI 10.1212/wnl.46.6.1592

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Abstract

We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2) High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.

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Authors: Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A.
Affiliations: University of California San Diego (US)
Emory University (US)
Washington University in St. Louis (US)
University of Washington (US)
Duke University (US)
ORCID: Ellis, R. J.
Olichney, J. M.
Morris, J. C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-06
Volume: 46
Issue: 6
Pages: 1592-1596
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.46.6.1592
OpenAlex: W2020068741
Cited by: 561
References: 26
Citations by year: 2026: 5 · 2025: 26 · 2024: 18 · 2023: 10 · 2022: 20 · 2021: 38 · 2020: 32 · 2019: 23 · 2018: 17 · 2017: 26 · 2016: 27 · 2015: 30 · 2014: 20 · 2013: 23 · 2012: 17
FWCI: 8.00
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Chinese Academy of Agricultural Sciences
National Institute on Aging (AG06790, AG05131, P50AG005131, U01AG006790)
Topics: Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: cerebral amyloid angiopathy, Alzheimer's disease, intracerebral hemorrhage, ischemic lesions, cerebral arteriosclerosis, atherosclerosis, vascular pathology
MeSH terms: Aged, Alzheimer Disease, Arteriosclerosis, Brain, Cerebral Hemorrhage, Brain Ischemia, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, United States, Comorbidity, Cerebral Amyloid Angiopathy

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Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

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