The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance
Abstract
This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to-father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.
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“In this respect, both mothers and fathers contribute to their offspring's AD risk, but because mitochondrial DNA (mtDNA) is maternally inherited mothers contribute more.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [113]
In the citing paper
“Cognitively normal, middle-aged individuals with AD mothers, who have a higher risk of developing AD than middle aged individuals with AD fathers or no AD-affected parents [131], have relatively low platelet COX activities [132].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [131]
Citations
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Cited by
Sorted by citations
Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786
A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758
Mitochondrial dysfunction in neurodegenerative diseases
Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 611
Metadata
- Authors
- Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., & Morris, J. C.
- Affiliations
- University of Washington (US)
- Venue
- Neurology
- Published
- 1996-07
- Volume
- 47
- Issue
- 1
- Pages
- 254-256
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2154744393
- Cited by
- 145
- References
- 10
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 8
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG06790, AG 05136, U01AG006790, P50AG005136)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, dementia, maternal inheritance, familial aggregation, genetic risk
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Humans, Mothers, Risk Factors, Survival Analysis
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