Cited by 145Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., Morris, J. C.·1996·Neurology

DOI 10.1212/wnl.47.1.254

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Abstract

This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to-father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.

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Authors: Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., & Morris, J. C.
Affiliations: University of Washington (US)
ORCID: Edland, S. D.
Peskind, E. R.
Tsuang, D.
Wijsman, E.
Morris, J. C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-07
Volume: 47
Issue: 1
Pages: 254-256
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.47.1.254
OpenAlex: W2154744393
Cited by: 145
References: 10
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 8
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG06790, AG 05136, U01AG006790, P50AG005136)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: Alzheimer's disease, dementia, maternal inheritance, familial aggregation, genetic risk
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Humans, Mothers, Risk Factors, Survival Analysis

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Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

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