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Quantitation of epidermal nerves in diabetic neuropathy
Abstract
We describe methods to quantify epidermal nerve fibers (ENFs) in skin biopsy specimens from diabetic candidates for pancreas transplantation and control subjects. ENFs and the dermal-epidermal basement membrane were stained by immunohistochemical methods, imaged with a confocal microscope, and quantified using a neuron tracing system. The number of ENFs per surface of epidermis was diminished in diabetic subjects. ENF number and summed length of all ENFs per volume of epidermis examined were also decreased. Length and number of branch points of single surviving ENFs were similar in skin of control and diabetic subjects. The methods and results constitute a basis for continued study of the effects of the euglycemia that attends successful pancreas transplantation and the effects of therapy in patients with various types of polyneuropathy.
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Citations
Cited by
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632
Epidermal Nerve Fiber Density: Normative Reference Range and Diagnostic Efficiency
McArthur, J. C., Stocks, E. A., Hauer, P., Cornblath, D. R., & Griffin, J. W. (1998) · Archives of Neurology · doi:10.1001/archneur.55.12.1513 · Cited by 560
Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., Smith, A. G., Hsieh, S., Mellgren, S. I., Umapathi, T., et al. (2010) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2010.00271.x · Cited by 518
Vinik, A. I., Park, T. S., Stansberry, K. B., & Pittenger, G. L. (2000) · Diabetologia · doi:10.1007/s001250051477 · Cited by 489
Mechanism of diabetic neuropathy: Where are we now and where to go?
Yagihashi, S., Mizukami, H., & Sugimoto, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00070.x · Cited by 488
Metadata
- Authors
- Kennedy, W. R., Wendelschafer-Crabb, G., & Johnson, T.
- Venue
- Neurology
- Published
- 1996-10
- Volume
- 47
- Issue
- 4
- Pages
- 1042-1048
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2145417494
- Cited by
- 436
- References
- 0
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kennedy, W. R., Wendelschafer-Crabb, G., & Johnson, T. (1996). Quantitation of epidermal nerves in diabetic neuropathy. Neurology. https://doi.org/10.1212/wnl.47.4.1042
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
