The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The pharmacology and mechanism of action of riluzole
Abstract
The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the possibility of using compounds that will block excitotoxic processes to treat neurologic disorders. Riluzole is a neuroprotective drug that blocks glutamatergic neurotransmission in the CNS. Riluzole inhibits the release of glutamic acid from cultured neurons, from brain slices, and from corticostriatal neurons in vivo. It is thought these effects may be partly due to inactivation of voltage-dependent sodium channels on glutamatergic nerve terminals, as well as activation of a G-protein-dependent signal transduction process. Riluzole also blocks some of the postsynaptic effects of glutamic acid by noncompetitive blockade of N-methyl-D-aspartate (NMDA) receptors. In vivo, riluzole has neuroprotective, anticonvulsant, and sedative properties. In a rodent model of transient global cerebral ischemia, a complete suppression of the ischemia-evoked surge in glutamic acid release has been observed. In vitro, riluzole protects cultured neurons from anoxic damage, from the toxic effects of glutamic-acid-uptake inhibitors, and from the toxic factor in the CSF of patients with amyotrophic lateral sclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,658
Martin, D., Thompson, M. A., & Nadler, J. V. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90037-i · Cited by 256
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study
Benazzouz, A., Boraud, T., Dubédat, P., Boireau, A., Stutzmann, J.-M., & Gross, C. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00362-o · Cited by 223
Debono, M.-W., Le Guern, J., Canton, T., Doble, A., & Pradier, L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90147-a · Cited by 210
Self-citationCouratier, P., Sindou, P., Hugon, J., Couratier, P., Hugon, J., Vallat, J.-M., & Dumas, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92615-z · Cited by 189
Is the adipocyte β-adrenoceptor a prototype for the recently cloned atypical ‘β3-adrenoceptor?’
Zaagsma, J., & Nahorskii, S. R. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90032-4 · Cited by 147
Differential pharmacology of cloned human and mouse B2 bradykinin receptors.
Hess, J. F., Borkowski, J. A., MacNeil, T., Stonesifer, G. Y., Fraher, J., Strader, C. D., & Ransom, R. W. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09890-6 · Cited by 142
Hubert, J., Delumeau, J.-C., Glowinski, J., Prémont, J., & Doble, A. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb16203.x · Cited by 127
Self-citationNeuroprotective effects of riluzole on a model of Parkinson's disease in the rat
Barnéoud, P., Mazadier, M., Miquet, J.-M., Parmentier, S., Dubédat, P., Doble, A., & Boireau, A. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00249-7 · Cited by 81
Self-citationLeigh, P. N., & Meldrum, B. S. (1996) · Neurology · doi:10.1212/wnl.47.6_suppl_4.221s · Cited by 71
Cited by
Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Dominguez, L., Shea, J.-E., Dokholyan, N. V., De Simone, A., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 678
Del Negro, C. A., Funk, G. D., & Feldman, J. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0003-6 · Cited by 663
Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., & Gage, F. H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.10.001 · Cited by 475
Understanding the Rhythm of Breathing: So Near, Yet So Far
Feldman, J. L., Del Negro, C. A., & Gray, P. A. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-040510-130049 · Cited by 459
Astrocytes in Alzheimer's Disease
Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C.-Y., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 455
Metadata
- Authors
- Doble, A.
- Venue
- Neurology
- Published
- 1996-12
- Volume
- 47
- Issue
- 6_suppl_4
- Pages
- S233-41
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2049958331
- Cited by
- 698
- References
- 14
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The pharmacology and mechanism of action of riluzole. https://app.cochat.ai/papers/10.1212/wnl.47.6_suppl_4.233s
- The paper
- Doble, A. (1996). The pharmacology and mechanism of action of riluzole. Neurology. https://doi.org/10.1212/wnl.47.6_suppl_4.233s
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
