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Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children
Abstract
Propofol, a new anesthetic, is now used more commonly to sedate patients in the intensive care unit. Propofol's rapid elimination has popularized its use to induce and maintain hypnosis in patients with refractory status epilepticus. It is also associated with occasional severe metabolic acidosis and hypoxia of indeterminate cause in children. We report a child and an adolescent who developed severe metabolic acidosis, progressive hypoxia, and rhabdomyolysis during maintenance infusion of propofol for the treatment of refractory status epilepticus. We suggest that propofol should not be used for prolonged sedation in children until its safety can be ensured.
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Citations
Cited by
Propofol infusion syndrome in children
Bray (1998) · Pediatric Anesthesia · doi:10.1046/j.1460-9592.1998.00282.x · Cited by 533
Kam, P. C. A., & Cardone, D. (2007) · Anaesthesia · doi:10.1111/j.1365-2044.2007.05055.x · Cited by 498
Warren, J. D., Blumbergs, P. C., & Thompson, P. D. (2002) · Muscle & Nerve · doi:10.1002/mus.10053 · Cited by 431
Propofol infusion syndrome: a structured literature review and analysis of published case reports
Hemphill, S., McMenamin, L., Bellamy, M. C., & Hopkins, P. M. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.12.025 · Cited by 331
HMG-CoA Reductase Inhibitors and Myotoxicity
Ucar, M., Mjorndal, T., & Dahlqvist, R. (2000) · Drug Safety · doi:10.2165/00002018-200022060-00003 · Cited by 279
Metadata
- Authors
- Hanna, J. P., & Ramundo, M. L.
- Venue
- Neurology
- Published
- 1998-01
- Volume
- 50
- Issue
- 1
- Pages
- 301-303
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2062492385
- Cited by
- 200
- References
- 0
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hanna, J. P., & Ramundo, M. L. (1998). Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children. Neurology. https://doi.org/10.1212/wnl.50.1.301
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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