The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Propofol infusion syndrome
Abstract
Summary: The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol.l −1 ), rhabdomyolysis, hyperlipidaemia, and enlarged or fatty liver. There is an association between PRIS and propofol infusions at doses higher than 4 mg.kg −1 .h −1 for greater than 48 h duration. Sixty‐one patients with PRIS have been recorded in the literature, with deaths in 20 paediatric and 18 adult patients. Seven of these patients (four paediatric and three adult patients) developed PRIS during anaesthesia. It is proposed that the syndrome may be caused by either a direct mitochondrial respiratory chain inhibition or impaired mitochondrial fatty acid metabolism mediated by propofol. An early sign of cardiac instability associated with the syndrome is the development of right bundle branch block with convex‐curved (‘coved type’) ST elevation in the right praecordial leads (V1 to V3) of the electrocardiogram. Predisposing factors include young age, severe critical illness of central nervous system or respiratory origin, exogenous catecholamine or glucocorticoid administration, inadequate carbohydrate intake and subclinical mitochondrial disease. Treatment options are limited. Haemodialysis or haemoperfusion with cardiorespiratory support has been the most successful treatment.
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The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome
Vasile, B., Rasulo, F., Candiani, A., & Latronico, N. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1905-x · Cited by 568
Propofol infusion syndrome in children
Bray (1998) · Pediatric Anesthesia · doi:10.1046/j.1460-9592.1998.00282.x · Cited by 533
Impaired fatty acid oxidation in propofol infusion syndrome
Wolf, A., Weir, P., Segar, P., Stone, J., & Shield, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04064-2 · Cited by 393
Jouven, X., Charles, M.-A., Desnos, M., & Ducimetière, P. (2001) · Circulation · doi:10.1161/hc3201.094151 · Cited by 256
Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children
Hanna, J. P., & Ramundo, M. L. (1998) · Neurology · doi:10.1212/wnl.50.1.301 · Cited by 200
Strickland, R. A., & Murray, M. J. (1995) · Critical Care Medicine · doi:10.1097/00003246-199502000-00029 · Cited by 116
Fatal Propofol Infusion Syndrome in Association with Ketogenic Diet
Baumeister, F. A. M., Oberhoffer, R., Liebhaber, G., Kunkel, J. M., Eberhardt, J., Holthausen, H., & Peters, J. P. (2004) · Neuropediatrics · doi:10.1055/s-2004-820992 · Cited by 116
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Continuous Propofol Infusion in 142 Critically Ill Children
Cornfield, D. N., Tegtmeyer, K., Nelson, M. D., Milla, C. E., & Sweeney, M. F. (2002) · PEDIATRICS · doi:10.1542/peds.110.6.1177 · Cited by 100
Cited by
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Etiology and Therapeutic Approach to Elevated Lactate Levels
Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.012 · Cited by 731
Propofol infusion syndrome: a structured literature review and analysis of published case reports
Hemphill, S., McMenamin, L., Bellamy, M. C., & Hopkins, P. M. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.12.025 · Cited by 331
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun-Buisson, C., Beale, R., et al. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000298158.12101.41 · Cited by 9
Metadata
- Authors
- Kam, P. C. A., & Cardone, D.
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 2007-06-12
- Volume
- 62
- Issue
- 7
- Pages
- 690-701
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W1997349469
- Cited by
- 498
- References
- 20
- FWCI
- 42.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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