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Prognostic indicators of survival in ALS
Abstract
We analyzed data from the 245-patient placebo group of the ALS CNTF Treatment Study Group study, a large, prospective, multicenter study of recombinant human ciliary neurotrophic factor to determine prognostic factors for length of survival in ALS. Variables examined included baseline demographic characteristics, indices of disease severity, pulmonary function, and clinical laboratory tests. Shorter survival was associated with greater age, lower percent-predicted forced vital capacity (FVC%), and lower serum chloride at study entry. A shorter interval from symptom onset to diagnosis of ALS and greater weight loss in the 2 months before study entry also predicted shortened survival times. The rate of muscle strength loss before study entry did not predict risk of mortality. Serum chloride, reflecting the degree of respiratory acidosis, was identified for the first time as being correlated with prognosis in ALS. The relationship between a patient's FVC% and the probability of survival is described.
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Cited by
Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00210-5 · Cited by 3,307
Self-citationKiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603
Prognostic factors in ALS: A critical review
Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802566824 · Cited by 1,172
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649
Prognosis in amyotrophic lateral sclerosis: A population-based study
del Aguila, M. A., Longstreth, W. T., McGuire, V., Koepsell, T. D., & van Belle, G. (2003) · Neurology · doi:10.1212/01.wnl.0000049472.47709.3b · Cited by 469
Metadata
- Authors
- Stambler, N., Charatan, M., Cedarbaum, J. M., & ALS CNTF Treatment Study Group*
- Venue
- Neurology
- Published
- 1998-01
- Volume
- 50
- Issue
- 1
- Pages
- 66-72
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2130462384
- Cited by
- 254
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stambler, N., Charatan, M., Cedarbaum, J. M., & ALS CNTF Treatment Study Group*. (1998). Prognostic indicators of survival in ALS. Neurology. https://doi.org/10.1212/wnl.50.1.66
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
