The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The ischemic penumbra: Operationally defined by diffusion and perfusion MRI
Abstract
BACKGROUND: Identifying tissue at risk for infarction is important in deciding which patients would benefit most from potentially harmful therapies and provides a way to evaluate newer therapies with regard to the amount of ischemic tissue salvaged. OBJECTIVE: To operationally define and characterize cerebral tissue at risk for stroke progression. METHODS: We retrospectively selected 25 patients with an acute onset of a hemispheric stroke from our database who had undergone a combination of two diffusion-weighted MRI studies and a perfusion-weighted MRI study. We applied a logistic regression model using maps of the relative mean transit time and relative cerebral blood flow (rCBF) as well as three different maps of the relative cerebral blood volume (rCBV) to predict an operationally defined penumbra (region of mismatch between the diffusion lesion on day 1 and its extension 24 to 72 hours later). RESULTS: Maps of the rCBF and initial rCBV were significant predictors for identifying penumbral tissue. Our operationally defined penumbral region was characterized by a reduction in the initial rCBV (47% of contralateral control region [CCR]), an increase (163% of CCR) in the total rCBV, and a reduction (37% of CCR) in the rCBF, whereas the operationally defined ischemic core showed a more severe reduction in the rCBF (12% of CCR) and in the initial rCBV (19% of CCR). CONCLUSION: These MR indexes may allow the identification and quantification of viable but ischemically threatened cerebral tissue amenable to therapeutic interventions in the hyperacute care of stroke patients.
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Citations
Cites
Thresholds in cerebral ischemia - the ischemic penumbra.
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Perfusion imaging with NMR contrast agents
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Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging
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Self-citationFast magnetic resonance diffusion-weighted imaging of acute human stroke
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Self-citationFunctional cerebral imaging by susceptibility‐contrast NMR
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Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI
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Cited by
Adams, H. P., Adams, R. J., Brott, T., del Zoppo, G. J., Furlan, A., Goldstein, L. B., Grubb, R. L., Higashida, R., Kidwell, C., Kwiatkowski, T. G., et al. (2003) · Stroke · doi:10.1161/01.str.0000064841.47697.22 · Cited by 1,245
A new penumbra: transitioning from injury into repair after stroke
Lo, E. H. (2008) · Nature Medicine · doi:10.1038/nm1735 · Cited by 611
Pathophysiology and therapy of experimental stroke
Hossmann, K.-A. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9008-1 · Cited by 475
Kidwell, C. S., Alger, J. R., & Saver, J. L. (2003) · Stroke · doi:10.1161/01.str.0000097608.38779.cc · Cited by 473
Fiebach, J. B., Schellinger, P. D., Gass, A., Kucinski, T., Siebler, M., Villringer, A., Ölkers, P., Hirsch, J. G., Heiland, S., Wilde, P., et al. (2004) · Stroke · doi:10.1161/01.str.0000114203.75678.88 · Cited by 434
Metadata
- Authors
- Schlaug, G., Benfield, A., Baird, A. E., Siewert, B., Lövblad, K. O., Parker, R. A., Edelman, R. R., & Warach, S.
- Venue
- Neurology
- Published
- 1999-10-22
- Volume
- 53
- Issue
- 7
- Pages
- 1528-1528
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2009904478
- Cited by
- 663
- References
- 37
- FWCI
- 26.03
- Type
- journal article
- Language
- en
- Open access
- closed
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