The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Beyond Mismatch: Evolving Paradigms in Imaging the Ischemic Penumbra With Multimodal Magnetic Resonance Imaging
Open accessAbstract
Background— The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appropriate candidates for early stroke therapies and identify patients who may still benefit from late recanalization or neuroprotective treatment. Recent advances in magnetic resonance imaging of the ischemic penumbra have been driven by serial MRI studies characterizing the natural evolution of cerebral infarction as well as the brain’s response to reperfusion. Summary of Comment— Based on these studies, various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. Each model has its own unique advantages and disadvantages. Conclusions— There now are sufficient data to support paradigm shifts in a variety of central tenets regarding MRI and the ischemic penumbra. These include the insights that diffusion-perfusion mismatch does not optimally define the penumbra; that early diffusion lesions are in part reversible and often include both irreversibly infarcted tissue and penumbra; that the visible zone of perfusion abnormality overestimates the penumbra by including regions of benign oligemia; that MRI is a very practical method for acute stroke imaging; and that therapeutic salvage of the ischemic penumbra has been demonstrated in humans using diffusion-perfusion MRI.
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Cites
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Viability thresholds and the penumbra of focal ischemia
Hossmann, K. (1994) · Annals of Neurology · doi:10.1002/ana.410360404 · Cited by 1,370
Kidwell, C. S., Saver, J. L., Mattiello, J., Starkman, S., Vinuela, F., Duckwiler, G., Gobin, Y. P., Jahan, R., Vespa, P., Kalafut, M., et al. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4<462::aid-ana9>3.0.co;2-y · Cited by 692
Self-citationThe ischemic penumbra: Operationally defined by diffusion and perfusion MRI
Schlaug, G., Benfield, A., Baird, A. E., Siewert, B., Lövblad, K. O., Parker, R. A., Edelman, R. R., & Warach, S. (1999) · Neurology · doi:10.1212/wnl.53.7.1528 · Cited by 663
Baird, A. E., Benfield, A., Schlaug, G., Siewert, B., Lövblad, K., Edelman, R. R., & Warach, S. (1997) · Annals of Neurology · doi:10.1002/ana.410410506 · Cited by 581
Diffusion- and Perfusion-Weighted MRI: The DWI/PWI Mismatch Region in Acute Stroke
Neumann-Haefelin, T., Wittsack, H.-J., Wenserski, F., Siebler, M., Seitz, R. J., Mödder, U., & Freund, H.-J. (1999) · Stroke · doi:10.1161/01.str.30.8.1591 · Cited by 568
Magnetic Resonance Imaging of Acute Stroke
Baird, A. E., & Warach, S. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199806000-00001 · Cited by 545
Mintorovitch, J., Moseley, M. E., Chileuitt, L., Shimizu, H., Cohen, Y., & Weinstein, P. R. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910180106 · Cited by 507
Progressive Derangement of Periinfarct Viable Tissue in Ischemic Stroke
Heiss, W.-D., Huber, M., Fink, G. R., Herholz, K., Pietrzyk, U., Wagner, R., & Wienhard, K. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.29 · Cited by 433
Mapping the Ischaemic Penumbra with PET: Implications for Acute Stroke Treatment
Baron, J.-C. (1999) · Cerebrovascular Diseases · doi:10.1159/000015955 · Cited by 357
Cited by
Real‐time diffusion‐perfusion mismatch analysis in acute stroke
Straka, M., Albers, G. W., & Bammer, R. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22338 · Cited by 401
Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke
Olivot, J.-M., Mlynash, M., Thijs, V. N., Kemp, S., Lansberg, M. G., Wechsler, L., Bammer, R., Marks, M. P., & Albers, G. W. (2009) · Stroke · doi:10.1161/strokeaha.108.526954 · Cited by 401
Early Neutrophilia Is Associated With Volume of Ischemic Tissue in Acute Stroke
Buck, B. H., Liebeskind, D. S., Saver, J. L., Bang, O. Y., Yun, S. W., Starkman, S., Ali, L. K., Kim, D., Villablanca, J. P., Salamon, N., et al. (2008) · Stroke · doi:10.1161/strokeaha.107.490128 · Cited by 314
Self-citationThe Two Pathophysiologies of Focal Brain Ischemia: Implications for Translational Stroke Research
Hossmann, K.-A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.186 · Cited by 220
Merino, J. G., & Warach, S. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.129 · Cited by 152
Metadata
- Authors
- Kidwell, C. S., Alger, J. R., & Saver, J. L.
- Venue
- Stroke
- Published
- 2003-11
- Volume
- 34
- Issue
- 11
- Pages
- 2729-2735
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2112571673
- Cited by
- 473
- References
- 39
- Type
- journal article
- Language
- en
- Open access
- bronze
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