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Cited by 184Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHealth disparities and outcomes

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Marital status and risk of Alzheimer’s disease: A French population-based cohort study

Helmer, C., Damon, D., Letenneur, L., Fabrigoule, C., Barberger-Gateau, P., Lafont, S., Fuhrer, R., Antonucci, T., Commenges, D., Orgogozo, J.M., Dartigues, J.F.·1999·Neurology
DOI 10.1212/wnl.53.9.1953
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Abstract

OBJECTIVE: To analyze the relationship between marital status and risk of AD or dementia. METHODS: This study was carried out from the Personnes Agées QUID (PAQUID) cohort, an epidemiologic study on normal and pathologic aging after age 65 years. The PAQUID cohort began in 1988. Individuals were followed up at 1, 3, and 5 years, with an active detection of dementia. Marital status was divided into four categories: widowed, never married, divorced or separated, and the reference category, married or cohabitant. The longitudinal relationship between marital status and risk of incident AD or dementia was analyzed by a Cox model with delayed entry. RESULTS: Among the 3,675 individuals initially not demented, 2,106 were married or cohabitants, 1,287 were widowers, 179 were never married, and 103 were divorced or separated. Among the 2,881 individuals reevaluated at least once for the risk of dementia during the 5-year follow-up, 190 incident cases of dementia were identified, including 140 with AD. The relative risks (RRs) of dementia (RR = 1.91, p = 0.018) and of AD (RR = 2.68, p<0.001) were increased for the never-married individuals compared with those who were married or cohabitants. This excess of risk was specifically associated with AD. Adjustment for other risk factors of dementia (education, wine consumption), or for factors reflecting social environment, leisure activities, and depression, did not modify the risk of AD for never-married individuals (RR = 2.31, p = 0.02). CONCLUSIONS: We confirmed an association between marital status and AD, with an excess risk observed among never-married individuals. This association may provide clues about the pathogenesis of AD.

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Research works printed but not linked: 4

  1. Fratiglioni L. Epidemiology of Alzheimer’s disease and current possibilities for prevention. Acta Neurol Scand 1996;165 (suppl):33–40.
  2. Tsolaki M, Fountoulakis K, Chantzi E, Kazis A. Risk factors for clinically diagnosed Alzheimer’s disease: a case-control study of a Greek population. Int Psychogeriatr 1997;9:327–341.
  3. Kalbfleisch J Prentice R. The statistical analysis of failure time data. New York:Wiley 1980.
  4. Dartigues JF, Gagnon M, Michel P, et al. Le programme de recherche PAQUID sur l’épidémiologie de la démence: méthodologie et résultats initiaux. Rev Neurol (Paris) 1991;147:225–230.

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Authors
Helmer, C., Damon, D., Letenneur, L., Fabrigoule, C., Barberger-Gateau, P., Lafont, S., Fuhrer, R., Antonucci, T., Commenges, D., Orgogozo, J. M., & Dartigues, J. F.
Affiliations
  • Université de Bordeaux (FR)
  • From INSERM U 330 (Drs. HelmerDamon, Letenneur, Fabrigoule, Barberger-Gateau, Commenges, Orgogozo, and Dartigues, and S. Lafont), Université de Bordeaux II; Fédération de Neurologie (Drs. Orgogozo and Dartigues), CHU de Bordeaux; and INSERM U 360 (Dr. Fuhrer), Recherches Epidémiologiques en Neurologie et Psychopathologie, Paris, France; and the Institute for Social Research (Dr. Antonucci), The University of Michigan, Ann Arbor, MI.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-12
Volume
53
Issue
9
Pages
1953-1953
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.53.9.1953
OpenAlex
W2087596425
Cited by
184
References
18
Citations by year
2025: 3 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 14 · 2020: 6 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 9 · 2012: 8
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Social Sciences › Health › Health disparities and outcomes
Keywords
marital status, Alzheimer's disease, dementia, widowhood, social environment, PAQUID cohort, older adults
MeSH terms
Aged, Alzheimer Disease, Female, Follow-Up Studies, France, Humans, Male, Middle Aged, Risk, Single Person, Social Support, Cohort Studies, Marital Status

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