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Cited by 197Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Prevalence of Alzheimer’s disease in very elderly people: A prospective neuropathological study

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Polvikoski, T., Sulkava, R., Myllykangas, L., Notkola, I.-L., Niinistö, L., Verkkoniemi, A., Kainulainen, K., Kontula, K., Pérez–Tur, J., Hardy, J., Haltia, M.·2001·Neurology
DOI 10.1212/wnl.56.12.1690
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Abstract

BACKGROUND: No previous autopsy-controlled, prospective, and population-based studies are available on the prevalence of AD in very elderly people. OBJECTIVE: To study the point prevalence of neuropathologically defined AD in a population of people at least 85 years of age, stratified according to their APOE genotype. METHODS: A population-based sample of 532 (of a total population of 601) elderly Finnish individuals, aged 85 years or more, were clinically tested for dementia in 1991 (with follow-up studies of the survivors in 1994, 1996, and 1999) and genotyped for APOE. An autopsy involving neuropathologic diagnosis of AD according to modified consensus criteria was performed in 118 of 198 deceased subjects who had been demented on April 1, 1991, and in 62 of 201 nondemented individuals. RESULTS: The prevalence of neuropathologically defined AD was 33%, whereas the prevalence of clinically diagnosed AD was 16%. There was a highly significant (p < 0.001) association between the APOE epsilon4 allele and AD: Sixty-three percent of APOE epsilon4 carriers and 20% of noncarriers had neuropathologic AD. The respective figures in subjects aged 90 years or more were 71 and 22%. CONCLUSIONS: The prevalence of neuropathologically defined AD is higher than that reported in most previous studies based on clinical diagnosis. The discrepancy between the neuropathologic and clinical diagnoses of AD in very elderly subjects may affect the results of population-based studies. The APOE genotype has a strong effect on the prevalence of neuropathologically defined AD, even after 90 years of age.

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Authors
Polvikoski, T., Sulkava, R., Myllykangas, L., Notkola, I.-L., Niinistö, L., Verkkoniemi, A., Kainulainen, K., Kontula, K., Pérez–Tur, J., Hardy, J., & Haltia, M.
Affiliations
  • University of Helsinki (FI)
  • From the Departments of Pathology (Drs. Polvikoski, Myllykangas, Verkkoniemi, and Haltia), Neurology (Dr. Verkkoniemi), and Medicine (Drs. Kainulainen and Kontula), University of Helsinki and Helsinki University Central Hospital, Finland; Faculty of Social Sciences (Dr. Notkola), University of Helsinki; Department of Public Health and General Practice (Dr. Sulkava), Division of Geriatrics, University of Kuopio and Kuopio University Hospital, Finland; Katriina Geriatric Hospital (Dr. Niinistö),...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-06-26
Volume
56
Issue
12
Pages
1690-1696
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.56.12.1690
OpenAlex
W2060355242
Cited by
197
References
41
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 25 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 10 · 2012: 5
FWCI
7.90
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, oldest old, prevalence, APOE ε4, APOE genotype, dementia, autopsy
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Finland, Genotype, Humans, Male, Prospective Studies, Prevalence

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