The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Gender and age modify the association between APOE and AD-related neuropathology
Abstract
Objective To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP). Methods A sample of 729 routine autopsy brains (359 men, 370 women; age range, 60 to 99 years) was investigated. All brains were classified neuropathologically according to a procedure permitting differentiation of six NFT stages and three SP stages. APOE genotyping was performed on all cases. Results The epsilon4 allele of APOE was associated not only with SP (p or =80 years (p or =80 years of age (p = 0.063). By comparison, men showed an association in both age categories (p = 0.001 and p = 0.001). Conclusion The results confirm the association between the epsilon4 allele and both types of AD-related lesions and show that this association is differentially modified by age and gender.
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“and another study reported that the association of APOE ε4 with neurofibrillary tangles was weaker in men than in women, while the association with senile plaques was significant in both sexes [24].”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [24]
In the citing paper
“Although two other studies reported differential associations between APOE ε4 and AD pathological indices in women and men [17,24], they do not contain any formal interaction test between sex and APOE ε4.”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [24]
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Apolipoprotein E polymorphism and Alzheimer's disease
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Miller, K. H. (2007) · OhioLink ETD Center (Ohio Library and Information Network)
Padgett, C. (2016) · UTAS Research Repository · doi:10.25959/23240147
Fine Particulate Matter, Neuropathologies, & Dementia
Shaffer, R. M. (2020) · ResearchWorks at the University of Washington (University of Washington)
(2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.378
Indenkleef, L. S. A. (2015) · Utrecht University Repository (Utrecht University)
Sex Differences in Cognition in Alzheimer's Disease
Irvine, K. (2014) · University of Hertfordshire Research Archive (University of Hertfordshire) · doi:10.18745/th.13879
Bax, F., Oltmer, J., Auger, C. A., Bonkhoff, A. K., Coughlan, G., Melloni, A. N., Jaisa-aad, M., Augustinack, J. C., Serrano‐Pozo, A., Frosch, M. P., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71206
Neubauer, A., Feyen, P., Pekrun, S., Roeber, S., Ruf, V., Strübing, F., & Herms, J. W. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03096-1
Metadata
- Authors
- Ghebremedhin, E., Schultz, C., Thal, D. R., Rüb, U., Ohm, T. G., Braak, E., & Braak, H.
- Affiliations
- Goethe University Frankfurt (DE)
- From the Department of Clinical Neuroanatomy (Drs. Ghebremedhin, Schultz, Thal, Rüb, E. Braak, and H. Braak) J.W. Goethe–University, Frankfurt, Germany; and the Department of Anatomy (Dr. Ohm), Medical Faculty Charité of the Humboldt University, Berlin, Germany.
- Venue
- Neurology
- Published
- 2001-06-26
- Volume
- 56
- Issue
- 12
- Pages
- 1696-1701
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1966014994
- Cited by
- 108
- References
- 37
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 5
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, APOE ε4, Alzheimer's disease, neurofibrillary tangles, amyloid plaques, sex differences, age effects, genetic susceptibility, neuropathology
- MeSH terms
- Age Factors, Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Female, Genotype, Humans, Male, Middle Aged, Sex Factors
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