Gender and age modify the association between APOE and AD-related neuropathology

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

Tang, M., Jacobs, D. M., Stern, Y., Marder, K. S., Schofield, P., Gurland, B. J., Andrews, H., & Mayeux, R. P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03356-9 · Cited by 1,647

Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157

Apolipoprotein E polymorphism and Alzheimer's disease

Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968

Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology

Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.685 · Cited by 643

Using Positron Emission Tomography and Florbetapir F 18 to Image Cortical Amyloid in Patients With Mild Cognitive Impairment or Dementia Due to Alzheimer Disease

Fleisher, A. S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.150 · Cited by 364

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

Hohman, T. J., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Gifford, K. A., Bush, W. S., Chibnik, L. B., Mukherjee, S., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0821 · Cited by 340

Sex differences in Alzheimer’s disease and common neuropathologies of aging

Oveisgharan, S., Arvanitakis, Z., Yu, L., Farfel, J., Schneider, J. A., & Bennett, D. A. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1920-1 · Cited by 330

Sex differences in cognitive impairment in Alzheimer’s disease

Laws, K. R., Irvine, K., & Gale, T. M. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.54 · Cited by 307

Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age

Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J. (2009) · Annals of Neurology · doi:10.1002/ana.21696 · Cited by 299

Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease

Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Ward, A. M., Huijbers, W., Rentz, D. M., Johnson, K. A., Sperling, R. A., & For the Alzheimer's Disease Neuroimaging Initiative, T. A. I. B. A. L. F. S. O. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000431 · Cited by 295

Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis

Irvine, K., Laws, K. R., Gale, T. M., & Kondel, T. K. (2012) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2012.712676 · Cited by 290

Apolipoprotein E ε4 allele, AD pathology, and the clinical expression of Alzheimer’s disease

Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Aggarwal, N. T., Arnold, S. E., Cochran, E. J., Berry-Kravis, E., & Bienias, J. L. (2003) · Neurology · doi:10.1212/01.wnl.0000042478.08543.f7 · Cited by 282

Better Memory and Neural Efficiency in Young Apolipoprotein E 4 Carriers

Mondadori, C. R. A., de Quervain, D. J. ‐., Buchmann, A., Mustovic, H., Wollmer, M. A., Schmidt, C. F., Boesiger, P., Hock, C., Nitsch, R. M., Papassotiropoulos, A., et al. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl103 · Cited by 277

Sex, Apolipoprotein E ε4 Status, and Hippocampal Volume in Mild Cognitive Impairment

Fleisher, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.953 · Cited by 268

APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease

Parhizkar, S., & Holtzman, D. M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101594 · Cited by 255

The Biphasic Relationship between Regional Brain Senile Plaque and Neurofibrillary Tangle Distributions: Modification by Age, Sex, and APOE Polymorphism

CORDER, E. H., GHEBREMEDHIN, E., TAYLOR, M. G., THAL, D. R., OHM, T. G., & BRAAK, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.005 · Cited by 254

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

Ungar, L., Altmann, A., & Greicius, M. D. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9272-x · Cited by 246

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

Tiraboschi, P., Hansen, L. A., Masliah, E., Alford, M., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000128091.92139.0f · Cited by 226

Higher Rates of Decline for Women and Apolipoprotein E ε4 Carriers

Holland, D., Desikan, R. S., Dale, A. M., & McEvoy, L. K. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3601 · Cited by 219

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

Fleisher, A. S., Chen, K., Liu, X., Ayutyanont, N., Roontiva, A., Thiyyagura, P., Protas, H., Joshi, A. D., Sabbagh, M., Sadowsky, C. H., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.017 · Cited by 202

Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression

Mortimer, J. A., Borenstein, A. R., Gosche, K. M., & Snowdon, D. A. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281869 · Cited by 194

Precortical Phase of Alzheimer's Disease ( AD )‐Related Tau Cytoskeletal Pathology

Stratmann, K., Heinsen, H., Korf, H., Turco, D. D., Ghebremedhin, E., Seidel, K., Bouzrou, M., Grinberg, L. T., Böhl, J., Wharton, S. B., et al. (2015) · Brain Pathology · doi:10.1111/bpa.12289 · Cited by 175

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.

Jellinger, K. A., Alafuzoff, I., Attems, J., Beach, T. G., Cairns, N. J., Crary, J. F., Dickson, D. W., Hof, P. R., Hyman, B. T., Jack, C. R., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1407-2 · Cited by 171

Patterns of subjective memory impairment in the elderly: association with memory performance

Jessen, F., Wiese, B., Cvetanovska, G., Fuchs, Â., Kaduszkiewicz, H., Kölsch, H., Luck, T., Mösch, E., Pentzek, M., Riedel-Heller, S. G., et al. (2007) · Psychological Medicine · doi:10.1017/s0033291707001122 · Cited by 157

APOE , vascular pathology, and the AD brain

Yip, A. G., McKee, A. C., Green, R. C., WELLS, J. S., Young, H., Cupples, L. A., & Farrer, L. A. (2005) · Neurology · doi:10.1212/01.wnl.0000168863.49053.4d · Cited by 155

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease

Kloske, C. M., & Wilcock, D. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00754 · Cited by 152

Neurodegeneration in Normal Brain Aging and Disease

Thal, D. R., Del Tredici, K., & Braak, H. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.23.pe26 · Cited by 149

The Influence of Alzheimer Disease Family History and Apolipoprotein E ε4 on Mesial Temporal Lobe Activation

Johnson, S. C., Schmitz, T. W., Trivedi, M. A., Ries, M. L., Torgerson, B. M., Carlsson, C. M., Asthana, S., Hermann, B. P., & Sager, M. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0959-06.2006 · Cited by 154

Gender Differences in Alzheimer Disease: Brain Atrophy, Histopathology Burden, and Cognition

Filon, J. R., Intorcia, A. J., Sue, L. I., Vazquez Arreola, E., Wilson, J., Davis, K. J., Sabbagh, M. N., Belden, C. M., Caselli, R. J., Adler, C. H., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw047 · Cited by 143

Parenchymal and vascular Aβ‐deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

Thal, D. R., Griffin, W. S. T., & Braak, H. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00411.x · Cited by 134

Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease

Prohovnik, I., Perl, D. P., Davis, K. L., Libow, L. S., Lesser, G. T., & Haroutunian, V. H. (2006) · Neurology · doi:10.1212/01.wnl.0000191298.68045.50 · Cited by 131

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer’s disease

Lahiri, D. K., Sambamurti, K., & Bennett, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.024 · Cited by 131

Sex dimorphism profile of Alzheimer’s disease-type pathologies in an APP/PS1 mouse model

Jiao, S.-S., Bu, X.-L., Liu, Y.-H., Zhu, C., Wang, Q.-H., Shen, L.-L., Liu, C.-H., Wang, Y.-R., Yao, X.-Q., & Wang, Y.-J. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9589-x · Cited by 129

The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability in longitudinal data

Schmidt, M. E., Chiao, P., Klein, G., Matthews, D. C., Thurfjell, L., Cole, P. E., Margolin, R. A., Landau, S. M., Foster, N. L., Mason, N. S., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.09.004 · Cited by 125

Brain aging and Alzheimer's disease; use it or lose it

Swaab, D. F., Dubelaar, E. J. G., Hofman, M. A., Scherder, E., Someren, E. J. W. V., & Verwer, R. W. H. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38086-5 · Cited by 119

Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex

Qiu, C. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.021493 · Cited by 115

Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people

Bennett, D. A. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054445 · Cited by 99

High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe

Schultz, C., Ghebremedhin, E., Tredici, K. D., Rüb, U., & Braak, H. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00113-1 · Cited by 92

Gender differences in brain reserve

Perneczky, R., Drzezga, A. E., Diehl‐Schmid, J., Li, Y., & Kurz, A. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0558-z · Cited by 91

Apolipoprotein E isoform mediated regulation of nitric oxide release

Brown, C. M., Wright, E., Colton, C. A., Sullivan, P. M., Laskowitz, D. T., & Vitek, M. P. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00803-1 · Cited by 84

Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis

Liu, M., Bian, C., Zhang, J., & Wen, F. (2014) · Scientific Reports · doi:10.1038/srep04383 · Cited by 72

The influence of parental history of Alzheimer's disease and apolipoprotein E 4 on the BOLD signal during recognition memory

Xu, G., McLaren, D. G., Ries, M. L., Fitzgerald, M. E., Bendlin, B. B., Rowley, H. A., Sager, M. A., Atwood, C., Asthana, S., & Johnson, S. C. (2008) · Brain · doi:10.1093/brain/awn254 · Cited by 88

Association of APOE polymorphisms with disease severity in MS is limited to women

Kantarci, O. H., Hebrink, D. D., Achenbach, S. J., Pittock, S. J., Altıntaş, A., Schaefer-Klein, J. L., Atkinson, E. J., de Andrade, M., McMurray, C. T., Rodriguez, M., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000113721.83287.83 · Cited by 73

Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study

Corrada, M. M., Paganini‐Hill, A., Berlau, D. J., & Kawas, C. H. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.12.004 · Cited by 68

The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease‐related pathology

Thal, D. R., Schultz, C., Botez, G., Del Tredici, K., Mrak, R. E., Griffin, W. S. T., Wiestler, O. D., Braak, H., & Ghebremedhin, E. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00635.x · Cited by 69

Apolipoprotein E and central nervous system disorders: Reviews of clinical findings

Takeda, M., Martínez, R., Kudo, T., Tanaka, T., Okochi, M., Tagami, S., Morihara, T., Hashimoto, R., & Cacabelos, R. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02148.x · Cited by 66

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism

Wellington, C. L. (2004) · Clinical Genetics · doi:10.1111/j.0009-9163.2004.00280.x · Cited by 63

Influence of Cognitive Status, Age, and APOE-4 Genetic Risk on Brain FDDNP Positron-Emission Tomography Imaging in Persons Without Dementia

Small, G. W., Siddarth, P., Burggren, A. C., Kepe, V., Ercoli, L. M., Miller, K. J., Lavretsky, H., Thompson, P. M., Cole, G. M., Huang, S. C., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.516 · Cited by 58

Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease

Emamzadeh, F. N. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0942-9 · Cited by 54

Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease

Günther, C., Hadeln, K. V., Müller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R. M., Stoppe, G., Reiss, J., Gal, A., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.070 · Cited by 53

Sex Differences in Cognition Across Aging

Lee, B. H., Richard, J. E., de leon, R. G., Yagi, S., & Galea, L. A. M. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_309 · Cited by 59

Olfactory Deficits in Normal Aging and Alzheimer's Disease in the Polish Elderly Population

Makowska, I., Kłoszewska, I., Grabowska, A., Szatkowska, I., & Rymarczyk, K. (2011) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr011 · Cited by 48

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

Nicoll, J. A. R., Savva, G. M., Stewart, J., Matthews, F. E., Brayne, C., & Ince, P. G. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01130.x · Cited by 41

The APOE polymorphism and 1-year outcome in ischemic stroke: genotype–gender interaction

Gromadzka, G., Barańska-Gieruszczak, M., Sarzyńska-Długosz, I. M., Ciesielska, A., & Członkowska, A. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00880.x · Cited by 40

Neurosyphilis with complex partial status epilepticus and mesiotemporal MRI abnormalities mimicking herpes simplex encephalitis

Marano, E. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.022285 · Cited by 40

A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer’s disease

Licastro, F., Veglia, F., Chiappelli, M., Grimaldi, L. M. E., & Masliah, E. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.002 · Cited by 38

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

Rolyan, H., Feike, A. C., Upadhaya, A. R., Waha, A., Dooren, T. V., Haass, C., Birkenmeier, G., Pietrzik, C. U., LEUVEN, F. V., & Thal, D. R. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-010-0572-7 · Cited by 39

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype

Lane, R. M., & He, Y. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.12.005 · Cited by 35

CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

Kok, E., Luoto, T. M., Haikonen, S., Goebeler, S., Haapasalo, H. K., & Karhunen, P. J. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt71 · Cited by 36

A Convolutional Neural Network and Graph Convolutional Network Based Framework for AD Classification

Lin, L., Xiong, M., Zhang, G., Kang, W., Sun, S., Wu, S., & Initiative, A. D. N. (2023) · Sensors · doi:10.3390/s23041914 · Cited by 34

Mortality is associated with apolipoprotein E ɛ4 in nondemented adults with Down syndrome

Zigman, W. B., Jenkins, E. C., Tycko, B., Schupf, N., & Silverman, W. P. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.002 · Cited by 33

Molecular differences in Alzheimer's disease between male and female patients determined by integrative network analysis

Sun, L., Yang, S., Sun, H., Li, W., & Duan, S. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13852 · Cited by 32

Mild cognitive impairment: new neuropsychological and pharmacological target

Rivas-Vazquez, R. A., Mendez, C., Rey, G. J., & Carrazana, E. J. (2003) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(02)00167-1 · Cited by 37

A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults

Green, A. E., Gray, J. R., DeYoung, C. G., Mhyre, T. R., Padilla, R. M., DiBattista, A. M., & Rebeck, G. W. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.12.020 · Cited by 32

Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP

Kornecook, T. J., McKinney, A. P., Ferguson, M. T., & Dodart, J. ‐. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2009.00545.x · Cited by 27

APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP670, 671 mutation carriers: implications for late‐onset Alzheimer's disease

Bogdanović, N., Corder, E. H., Lannfelt, L., & Winblad, B. G. (2002) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2002.tb00187.x · Cited by 29

Reduced Physiological Complexity in Robust Elderly Adults with the APOE ε4 Allele

Cheng, D., Tsai, S., Hong, C., & Yang, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007733 · Cited by 28

Fine Particulate Matter and Markers of Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort

Shaffer, R. M., Li, G., Adar, S. D., Keene, C. D., Latimer, C. S., Crane, P. K., Larson, E. B., Kaufman, J. D., Carone, M., & Sheppard, L. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201005 · Cited by 27

Association of APOE with Parkinson disease age-at-onset in women.

Buchanan, D., Silburn, P., Prince, J., & Mellick, G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.080 · Cited by 29

A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

Haasl, R. J., Ahmadi, M. R., Meethal, S. V., Gleason, C. E., Johnson, S. C., Asthana, S., Bowen, R. L., & Atwood, C. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-37 · Cited by 26

Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains

Ghebremedhin, E., Thal, D. R., Schultz, C., & Braak, H. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00014-9 · Cited by 26

Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis

Jiang, Y., He, T., Deng, W., & Sun, P. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s143632 · Cited by 22

Neocortical Variation of Aβ Load in Fully Expressed, Pure Alzheimer's Disease

Cupidi, C., Capobianco, R., Goffredo, D., Marcon, G., Ghetti, B. F., Bugiani, O., Tagliavini, F., & Giaccone, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1205 · Cited by 22

Apolipoprotein E in Alzheimer’s Disease: Focus on Synaptic Function and Therapeutic Strategy

Qu, L., Xu, S., Lan, Z., Fang, S., Xu, Y., & Zhu, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04449-1 · Cited by 22

Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer’s disease

Spampinato, M. V., Langdon, B., Patrick, K., Parker, R., Collins, H., Pravatà, E., & Initiative, F. T. A. D. N. (2016) · Neuroradiology · doi:10.1007/s00234-016-1740-8 · Cited by 17

The Role of Cardiovascular Risk Factors in Alzheimer's Disease

Ravona‐Springer, R., Davidson, M., & Noy, S. (2003) · CNS Spectrums · doi:10.1017/s109285290001926x · Cited by 20

Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease.

Hanyu, H., Shimizu, S., Tanaka, Y., Takasaki, M., Koizumi, K., & Abe, K. (2004) · PubMed Central · Cited by 19

Association between APOE genotype and microglial cell morphology

Kloske, C. M., Gearon, M. D., Weekman, E. M., Rogers, C. B., Patel, E., Bachstetter, A. D., Nelson, P. T., & Wilcock, D. M. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad031 · Cited by 17

Sex modulates the apolipoprotein E ε4 effect on white matter and cortical functional connectivity in individuals with amnestic mild cognitive impairment

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