The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
MRI measurement of brain iron in patients with restless legs syndrome
Abstract
Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.
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“Autopsy and MRI investigations show decreased iron concentrations in the substantia nigra of patients with restless leg syndrome that are associated with disease severity.197,198”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [197]
Citations
Cites
The effect of age on the non-haemin iron in the human brain
Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427
Toward a better definition of the restless legs syndrome
Walters, A. S., Aldrich, M. S., Allen, R., Ancoli‐Israel, S., Buchholz, D., Chokroverty, S., Coccagna, G., Earley, C., Ehrenberg, B., Feest, T. G., et al. (1995) · Movement Disorders · doi:10.1002/mds.870100517 · Cited by 1,100
Self-citationAugmentation of the Restless Legs Syndrome With Carbidopa/Levodopa
Allen, R. P., & Earley, C. J. (1996) · SLEEP · doi:10.1093/sleep/19.3.205 · Cited by 453
Self-citationStriatal dopaminergic function in restless legs syndrome
Turjanski, N., Lees, A., & Brooks, D. (1999) · Neurology · doi:10.1212/wnl.52.5.932 · Cited by 445
Gelman, N., Gorell, J. M., Barker, P. B., Savage, R. M., Spickler, E. M., Windham, J. P., & Knight, R. A. (1999) · Radiology · doi:10.1148/radiology.210.3.r99fe41759 · Cited by 373
Self-citationCerebral generators involved in the pathogenesis of the restless legs syndrome
Bucher, S., Seelos, K., Oertel, W. H., Reiser, M. F., & Trenkwalder, C. (1997) · Annals of Neurology · doi:10.1002/ana.410410513 · Cited by 327
Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores
Bartzokis, G., Aravagiri, M., Oldendorf, W. H., Mintz, J., & Marder, S. R. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290406 · Cited by 172
Ma, J., & Wehrli, F. W. (1996) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1996.0060 · Cited by 157
Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)
Staedt, J., Stoppe, G., K�gler, A., Munz, D. L., Riemann, H., Emrich, D., & R�ther, E. (1993) · Journal of Neural Transmission · doi:10.1007/bf01244940 · Cited by 95
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Research works printed but not linked: 1
- Earley CJ, Connors JR, Allen RP. RLS patients have abnormally reduced CSF ferritin compared to normal controls. Neurology . 1999; 52 (suppl 2): A111-A112.
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819
The International Restless Legs Syndrome Study Group (2003) · Sleep Medicine · doi:10.1016/s1389-9457(02)00258-7 · Cited by 1,688
Allen, R. P., Picchietti, D. L., Garcı́a-Borreguero, D., Ondo, W. G., Walters, A. S., Winkelman, J. W., Zucconi, M., Ferri, R., Trenkwalder, C., & Lee, H. B. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.03.025 · Cited by 1,620
Self-citationNeuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
Connor, J. R., Boyer, P. J., Menzies, S. L., Dellinger, B., Allen, R. P., Ondo, W. G., & Earley, C. J. (2003) · Neurology · doi:10.1212/01.wnl.0000078887.16593.12 · Cited by 548
Self-citationAllen, R. P., & Earley, C. J. (2001) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200103000-00004 · Cited by 469
Self-citation
Metadata
- Authors
- Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 2001-01-23
- Volume
- 56
- Issue
- 2
- Pages
- 263-265
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057995083
- Semantic Scholar
- 625746e30bd55bfd738f1234deeed324587e6703
- Cited by
- 570
- References
- 9
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 18 · 2023: 13 · 2022: 17 · 2021: 11 · 2020: 23 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 26 · 2014: 29 · 2013: 25 · 2012: 23
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-01-06)
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- restless legs syndrome, brain iron, iron deficiency, R2* MRI, substantia nigra, putamen, RLS severity
- MeSH terms
- Aged, Brain, Humans, Iron, Middle Aged, Restless Legs Syndrome
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