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The effect of age on the non-haemin iron in the human brain
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Total iron concentrations increase with age in the substantia nigra, putamen, globus pallidus, caudate nucleus, and cortices.
“Total iron concentrations increase with age in the substantia nigra, putamen, globus pallidus, caudate nucleus, and cortices6,42–44 but why this increase is selective for some areas of the brain is unclear.”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [42]
Citations
Cites
INTRACELLULAR DISTRIBUTION OF ENZYMES
Schneider, W. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51025-5 · Cited by 1,104
Biochemistry of the Developing Nervous System
Glass, B. (1956) · AIBS Bulletin · doi:10.1093/aibsbulletin/6.2.34-e · Cited by 387
THE COPPER AND IRON CONTENT OF BRAIN AND LIVER IN THE NORMAL AND IN HEPATO-LENTICULAR DEGENERATION
Cumings, J. N. (1948) · Brain · doi:10.1093/brain/71.4.410 · Cited by 386
Spatz, H. (1922) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02865844 · Cited by 252
The Iron, Copper and Manganese Content of the Human Brain
Tingey, A. H. (1937) · Journal of Mental Science · doi:10.1192/bjp.83.345.452 · Cited by 43
The Iron Content of the Human Brain.—II
Tingey, A. H. (1938) · Journal of Mental Science · doi:10.1192/bjp.84.353.980 · Cited by 17
Über den quantitativen Eisennachweis im extrapyramidalmotorischen Kemsystem beim Menschen
Stein, F. J. (1923) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02869640 · Cited by 7
Siderosis of the globus pallidus: Its relation to bilateral necrosis
Hadfield, G. J. (1929) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700320116 · Cited by 6
Flagged first, then by citations
Research works printed but not linked: 3
- Gellerstedt N., 1933, Uppsala LäkFören. Förh., 38, 103
- Hallgren B., 1953, Uppsala Läk Fören. Förh., 59, 79
- Kevy S. S., 1955, Biochemistry of the Developing Nervous System, 208
Cited by
Sorted by citations
The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383
Structural maturation of neural pathways in children and adolescents: in vivo study
Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (1999) · Science · doi:10.1126/science.283.5409.1908 · Cited by 1,322
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149
Progressive multiple sclerosis: pathology and pathogenesis
Lassmann, H., van Horssen, J., & Mahad, D. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.168 · Cited by 1,033
Imaging iron stores in the brain using magnetic resonance imaging
Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968
Langkammer, C., Schweser, F., Krebs, N., Deistung, A., Goessler, W., Scheurer, E., Sommer, K., Reishofer, G., Yen, K., Fazekas, F., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.049 · Cited by 801
Myelin and iron concentration in the human brain: a quantitative study of MRI contrast
Stüber, C., Morawski, M., Schäfer, A., Labadie, C., Wähnert, M., Leuze, C., Streicher, M., Barapatre, N., Reimann, K., Geyer, S., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.02.026 · Cited by 635
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546
MRI measurement of brain iron in patients with restless legs syndrome
Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J. (2001) · Neurology · doi:10.1212/wnl.56.2.263 · Cited by 570
Hirsch, E. C., Brandel, J. ‐., Galle, P., Javoy‐Agid, F., & Agid, Y. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08170.x · Cited by 537
Iron and neurodegeneration in the multiple sclerosis brain
Hametner, S., Wimmer, I., Haider, L., Pfeifenbring, S., Brück, W., & Lassmann, H. (2013) · Annals of Neurology · doi:10.1002/ana.23974 · Cited by 519
Quantitative susceptibility mapping: current status and future directions
Haacke, E. M., Liu, S., Buch, S., Zheng, W., Wu, D., & Ye, Y. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2014.09.004 · Cited by 511
Iron metabolism in the CNS: implications for neurodegenerative diseases
Rouault, T. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3453 · Cited by 496
MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
Bilgic, B., Pfefferbaum, A., Rohlfing, T., Sullivan, E. V., & Adalsteinsson, E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.077 · Cited by 499
Sasaki, M., Shibata, E., Tohyama, K., Takahashi, J., Otsuka, K., Tsuchiya, K., Takahashi, S., Ehara, S., Terayama, Y., & Sakai, A. (2006) · Neuroreport · doi:10.1097/01.wnr.0000227984.84927.a7 · Cited by 496
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270421 · Cited by 472
Deistung, A., Schäfer, A., Schweser, F., Biedermann, U., Turner, R., & Reichenbach, J. R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.055 · Cited by 442
Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases
Jellinger, K., Paulus, W., Grundke-Iqbal, I., Riederer, P., & Youdim, M. B. H. (1990) · Journal of Neural Transmission - Parkinson's Disease and Dementia Section · doi:10.1007/bf02252926 · Cited by 445
Good, P. F., Olanow, C. W., & Perl, D. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91334-b · Cited by 427
Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00186.x · Cited by 401
An introduction to the free radical hypothesis in Parkinson's disease
Olanow, C. W. (1992) · Annals of Neurology · doi:10.1002/ana.410320703 · Cited by 382
Connor, J. R., Snyder, B. S., Beard, J. L., Fine, R. E., & Mufson, E. J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310214 · Cited by 374
Brain iron pathways and their relevance to Parkinson's disease
Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00608.x · Cited by 362
Overview of quantitative susceptibility mapping
Deistung, A., Schweser, F., & Reichenbach, J. R. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3569 · Cited by 338
Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270
Individual dopaminergic neurons show raised iron levels in Parkinson disease
Oakley, A. E., Collingwood, J. F., Dobson, J., Love, G., Perrott, H. R., Edwardson, J. A., Elstner, M., & Morris, C. M. (2007) · Neurology · doi:10.1212/01.wnl.0000262033.01945.9a · Cited by 273
Decreased ferritin levels in brain in Parkinson's disease
Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08814.x · Cited by 258
Pfefferbaum, A., Rohlfing, T., Rosenbloom, M. J., Chu, W., Colrain, I. M., & Sullivan, E. V. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.008 · Cited by 256
Shachar, D. B., Kahana, N., Kampel, V., Warshawsky, A., & Youdim, M. B. H. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.09.005 · Cited by 246
Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications
Bartzokis, G., Lu, P. H., Tishler, T. A., Fong, S. M., Oluwadara, B., Finn, J. P., Huang, D., Bordelon, Y., Mintz, J., & Perlman, S. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9352-7 · Cited by 238
Iron and neurodegenerative disorders
Thompson, K. J., Shoham, S., & Connor, J. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00510-x · Cited by 235
Iron in the basal ganglia in Parkinson's disease
Griffiths, P. D., Dobson, B. R., Jones, G. R., & Clarke, D. T. (1999) · Brain · doi:10.1093/brain/122.4.667 · Cited by 229
Mitochondrial iron metabolism and its role in neurodegeneration
Horowitz, M. P., & Greenamyre, J. T. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100354 · Cited by 195
Mechanisms of white matter damage in multiple sclerosis
Lassmann, H. (2014) · Glia · doi:10.1002/glia.22597 · Cited by 191
Increased basal ganglia iron levels in Huntington disease
Bartzokis, G., Cummings, J., Perlman, S., Hance, D. B., & Mintz, J. (1999) · Archives of Neurology · doi:10.1001/archneur.56.5.569 · Cited by 183
Isoforms of ferritin have a specific cellular distribution in the brain
Connor, J. R., Boeshore, K. L., Benkovic, S. A., & Menzies, S. L. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490370405 · Cited by 179
Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21731 · Cited by 176
Cortical iron reflects severity of Alzheimer's disease
van Duijn, S., Bulk, M., van Duinen, S. G., Nabuurs, R. J. A., van Buchem, M. A., van der Weerd, L., & Natté, R. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161143 · Cited by 172
“Aging itself leads to increased iron and ferritin concentrations of the cortex [26, 27], but the microscopically distribution of this age-related increase is unknown.”
BackgroundOestreicher, E., Sengstock, G. J., Riederer, P., Olanow, C. W., Dunn, A. J., & Arendash, G. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)90833-8 · Cited by 156
Microglial degeneration in the aging brain - bad news for neurons?
Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150
Neurodegeneration with brain iron accumulation–clinical syndromes and neuroimaging
Schipper, H. M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.016 · Cited by 141
Metzger, C. D. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00138 · Cited by 114
Faucheux, B. A., Martin, M., Beaumont, C., Hunot, S., Hauw, J., Agid, Y., & Hirsch, E. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01118.x · Cited by 116
Magnetic resonance imaging of brain iron
Schenck, J. F. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00431-8 · Cited by 116
Schröder, N., Figueiredo, L. S., & de Lima, M. N. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121996 · Cited by 113
Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer’s disease
Lassmann, H. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0607-8 · Cited by 112
Bishop, G. M., & Robinson, S. R. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02303-4 · Cited by 104
MRI assessment of iron deposition in multiple sclerosis
Ropele, S., de Graaf, W., Khalil, M., Wattjes, M. P., Langkammer, C., Rocca, M. A., Rovira, A., Palace, J., Barkhof, F., Filippi, M., et al. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22590 · Cited by 103
Age-dependent and gender-specific changes in mouse tissue iron by strain
Hahn, P., Song, Y., Ying, G.-S., He, X., Beard, J., & Dunaief, J. L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.06.006 · Cited by 98
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BackgroundDuyn, J. (2013) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2012.11.013 · Cited by 95
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Killilea, D. W., Atamna, H., Liao, C., & Ames, B. N. (2003) · Antioxidants & Redox Signaling · doi:10.1089/152308603770310158 · Cited by 92
Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-10.2010 · Cited by 85
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Greenwood, E. K., & Brown, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094402 · Cited by 84
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Belaidi, A. A., Gunn, A. P., Wong, B. X., Ayton, S., Appukuttan, A. T., Roberts, B. R., Duce, J. A., & Bush, A. I. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0656-x · Cited by 83
Brain iron deposition fingerprints in Parkinson's disease and progressive supranuclear palsy
Boelmans, K., Holst, B., Hackius, M., Finsterbusch, J., Gerloff, C., Fiehler, J., & Münchau, A. (2012) · Movement Disorders · doi:10.1002/mds.24926 · Cited by 80
Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys
Cass, W. A., Grondin, R., Andersen, A. H., Zhang, Z., Hardy, P. A., Hussey-Andersen, L. K., Rayens, W. S., Gerhardt, G. A., & Gash, D. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.010 · Cited by 67
Nandar, W., Neely, E. B., Unger, E., & Connor, J. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.009 · Cited by 64
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Parr, A. C., Calabro, F., Larsen, B., Tervo-Clemmens, B., Elliot, S., Foran, W., Olafsson, V., & Luna, B. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.101997 · Cited by 60
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Keogh, M. J., Jonas, P., Coulthard, A., Chinnery, P. F., & Burn, J. (2012) · Neurogenetics · doi:10.1007/s10048-011-0310-9 · Cited by 49
Zhu, G., Fan, G., Feng, C., Li, Y., Chen, Y., Zhou, F., Du, G., Jiao, H., Liu, Z., Xiao, X., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2012.11.024 · Cited by 48
Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B., & Vidal, R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.015 · Cited by 45
Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2553-12.2012 · Cited by 40
Iron deficiency alters discrete proteins in rat caudate nucleus and nucleus accumbens
Youdim, M. B. H., Sills, M. A., Heydorn, W. E., Creed, G. J., & Jacobowitz, D. M. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00681.x · Cited by 31
Travis, K. E., Curran, M. M., Torres, C., Leonard, M. K., Brown, T. T., Dale, A. M., Elman, J. L., & Halgren, E. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht052 · Cited by 19
Wimmer, I., Scharler, C., Zrzavy, T., Kadowaki, T., Mödlagl, V., Rojc, K., Tröscher, A. R., Kitic, M., Ueda, S., Bradl, M., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0667-9 · Cited by 19
Metadata
- Authors
- Hallgren, B., & Sourander, P.
- Affiliations
- Uppsala University (SE)
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1958-10
- Volume
- 3
- Issue
- 1
- Pages
- 41-51
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1981835221
- Cited by
- 1,427
- References
- 8
- Citations by year
- 2026: 26 · 2025: 43 · 2024: 40 · 2023: 44 · 2022: 67 · 2021: 54 · 2020: 46 · 2019: 49 · 2018: 72 · 2017: 59 · 2016: 75 · 2015: 56 · 2014: 72 · 2013: 76 · 2012: 56
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- non-heme iron, brain iron, aging, age-related changes, human brain
- MeSH terms
- Aging, Brain, Humans, Iron, Neurochemistry
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