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MRI measurement of brain iron in patients with restless legs syndrome
Abstract
Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.
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“Autopsy and MRI investigations show decreased iron concentrations in the substantia nigra of patients with restless leg syndrome that are associated with disease severity.197,198”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [197]
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Pelayo, R., & Dubik, M. (2008) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2008.03.004 · Cited by 77
Periodic limb movement disorder and restless legs syndrome in dialysis patients
Rijsman, R. M., de Weerd, A., Stam, C. J., KERKHOF, G. A., & Rosman, J. B. (2004) · Nephrology · doi:10.1111/j.1440-1797.2004.00330.x · Cited by 77
T2 relaxometry and fMRI of the brain in late-onset restless legs syndrome
Astrakas, L. G., Konitsiotis, S., Margariti, P. N., Tsouli, S. G., Tzarouhi, L., & Argyropoulou, M. I. (2008) · Neurology · doi:10.1212/01.wnl.0000325914.50764.a2 · Cited by 77
Restless legs syndrome: pathophysiology and the role of iron and folate.
Patrick, L. (2007) · PubMed · Cited by 77
Metadata
- Authors
- Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 2001-01-23
- Volume
- 56
- Issue
- 2
- Pages
- 263-265
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057995083
- Semantic Scholar
- 625746e30bd55bfd738f1234deeed324587e6703
- Cited by
- 570
- References
- 9
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 18 · 2023: 13 · 2022: 17 · 2021: 11 · 2020: 23 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 26 · 2014: 29 · 2013: 25 · 2012: 23
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-01-06)
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- restless legs syndrome, brain iron, iron deficiency, R2* MRI, substantia nigra, putamen, RLS severity
- MeSH terms
- Aged, Brain, Humans, Iron, Middle Aged, Restless Legs Syndrome
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