Cited by 240Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroprotection in Cerebral Ischemia

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Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease

Adair, John C., Knoefel, Janice E., Morgan, Nancy·2001·Neurology

DOI 10.1212/wnl.57.8.1515

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Abstract

The antioxidant N-acetylcysteine (NAC) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.

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Authors: Adair, J. C., Knoefel, J. E., & Morgan, N.
Affiliations: University of New Mexico (US)
ORCID: Adair, John C.
Knoefel, Janice E.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-10-23
Volume: 57
Issue: 8
Pages: 1515-1517
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.57.8.1515
OpenAlex: W2084485820
Cited by: 240
References: 10
Citations by year: 2026: 9 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 10
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: N-acetylcysteine, Alzheimer's disease, antioxidants, cognitive function, NIA-AA criteria, treatment efficacy
MeSH terms: Acetylcysteine, Alzheimer Disease, Double-Blind Method, Female, Humans, Male, Free Radical Scavengers, Treatment Outcome

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Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease

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