The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Special considerations in treating the elderly patient with epilepsy
Abstract
Epilepsy in elderly patients, compared with the younger adult population, differs in etiology, clinical presentation, and prognosis. Challenges in the pharmacologic treatment of epilepsy in the elderly include the following: the physiologic changes associated with aging; adverse events to which the elderly are especially vulnerable; the increased risk for these patients, who are often taking multiple medications; and toxicity from drug-drug interactions. This article presents data on efficacy and safety from clinical trials of newer antiepileptic drugs (AEDs) in elderly patients compared with older AEDs. We discuss the implications of the findings using newer-generation AEDs in the Veterans Affairs Cooperative Study (VACS) #428 in order to educate physicians involved in choosing appropriate AEDs for older patients. In the elderly patient population, an optimal treatment outcome of seizure control with minimal or no adverse events is dependent on the well-informed choice of an AED by a physician.
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Cites
Mattson, R. H., Cramer, J. A., Collins, J. F., Smith, D. B., Delgado-Escueta, A. V., Browne, T. R., Williamson, P. D., Treiman, D. M., McNamara, J. O., McCutchen, C. B., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507183130303 · Cited by 1,138
Mattson, R. H., Cramer, J. A., & Collins, J. F. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209103271104 · Cited by 683
Brodie, M. J., Overstall, P. W., & Giorgi, L. (1999) · Epilepsy Research · doi:10.1016/s0920-1211(99)00039-x · Cited by 459
Population-based study of seizure disorders after cerebral infarction
So, E. L., Annegers, J. F., Hauser, W. A., O'Brien, P. C., & Whisnant, J. P. (1996) · Neurology · doi:10.1212/wnl.46.2.350 · Cited by 400
Safety of Topiramate: Adverse Events and Relationships to Dosing
Shorvon, S. D. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb06029.x · Cited by 184
Topiramate as Add‐On Therapy: Pooled Analysis of Randomized Controlled Trials in Adults
Reife, R., Pledger, G., & Wu, S. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb02175.x · Cited by 166
Seizures and Epilepsy in the Elderly
THOMAS, R. J. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.6.605 · Cited by 161
Video‐EEG Monitoring in the Elderly: A Review of 94 Patients
McBride, A. E., Shih, T., & Hirsch, L. J. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.24401.x · Cited by 154
Myoclonus Associated with the Use of Gabapentin
Asconapé, J. J., Diedrich, A., & DellaBadia, J. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00192.x · Cited by 108
Cited by
Patsalos, P. N., Berry, D. J., Bourgeois, B. F. D., Cloyd, J. C., Glauser, T. A., Johannessen, S. I., Leppik, I. E., Tomson, T., & Perucca, E. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01561.x · Cited by 1,156
Role of oxidative stress in epileptic seizures
Shin, E.-J., Jeong, J. H., Chung, Y. H., Kim, W.-K., Ko, K.-H., Bach, J.-H., Hong, J.-S., Yoneda, Y., & Kim, H.-C. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.025 · Cited by 422
Sen, A., Jette, N., Husain, M., & Sander, J. W. (2020) · The Lancet · doi:10.1016/s0140-6736(19)33064-8 · Cited by 369
Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?
Costa, C., Parnetti, L., D'Amelio, M., Tozzi, A., Tantucci, M., Romigi, A., Siliquini, S., Cavallucci, V., Di Filippo, M., Mazzocchetti, P., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.025 · Cited by 94
Metadata
- Authors
- Ramsay, R. E., Rowan, A. J., & Pryor, F. M.
- Venue
- Neurology
- Published
- 2004-03-09
- Volume
- 62
- Issue
- 5_suppl_2
- Pages
- S24-9
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2136913469
- Cited by
- 295
- References
- 9
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
