The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration
Abstract
Studies using molecular modeling, genetic engineering, neurophysiology/pharmacology, and whole animals have advanced our understanding of where and how inhaled anesthetics act to produce immobility (minimum alveolar anesthetic concentration; MAC) by actions on the spinal cord. Numerous ligand- and voltage-gated channels might plausibly mediate MAC, and specific amino acid sites in certain receptors present likely candidates for mediation. However, in vivo studies to date suggest that several channels or receptors may not be mediators (e.g., gamma-aminobutyric acid A, acetylcholine, potassium, 5-hydroxytryptamine-3, opioids, and alpha(2)-adrenergic), whereas other receptors/channels (e.g., glycine, N-methyl-D-aspartate, and sodium) remain credible candidates.
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Cites
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219
Self-citationDo general anaesthetics act by competitive binding to specific receptors?
Franks, N. P., & Lieb, W. R. (1984) · Nature · doi:10.1038/310599a0 · Cited by 572 · cited 2×
“The seminal work of Franks and Lieb (23) shifted attention from lipids to proteins (specifically, ion channels) as anesthetic targets.”
BackgroundVolatile general anaesthetics activate a novel neuronal K+ current
Franks, N. P., & Lieb, W. R. (1988) · Nature · doi:10.1038/333662a0 · Cited by 199
Cited by
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295
Molecular and neuronal substrates for general anaesthetics
Rudolph, U., & Antkowiak, B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1496 · Cited by 772
Emerging molecular mechanisms of general anesthetic action
Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 552
Self-citationUpdate on Bispectral Index monitoring
Johansen, J. W. (2006) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 313
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
Horn, C. C., Wallisch, W. J., Homanics, G. E., & Williams, J. P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.037 · Cited by 288
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Metadata
- Authors
- Sonner, J. M., Antognini, J. F., Dutton, R. C., Flood, P., Gray, A. T., Harris, R. A., Homanics, G. E., Kendig, J., Orser, B., Raines, D. E., Trudell, J., Vissel, B., & Eger, A. E. I.
- Venue
- Anesthesia & Analgesia
- Published
- 2003-09
- Volume
- 97
- Issue
- 3
- Pages
- 718-740
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2060262374
- Cited by
- 328
- References
- 5
- FWCI
- 29.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration. https://app.cochat.ai/papers/10.1213/01.ane.0000081063.76651.33
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- Sonner, J. M., Antognini, J. F., Dutton, R. C., Flood, P., Gray, A. T., Harris, R. A., Homanics, G. E., Kendig, J., Orser, B., Raines, D. E., Trudell, J., Vissel, B., & Eger, A. E. I. (2003). Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration. Anesthesia & Analgesia. https://doi.org/10.1213/01.ane.0000081063.76651.33
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
