The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Anaphylaxis During the Perioperative Period
Abstract
Anesthesiologists use a myriad of drugs during the provision of an anesthetic. Many of these drugs have side effects that are dose related, and some lead to severe immune-mediated adverse reactions. Anaphylaxis is the most severe immune-mediated reaction; it generally occurs on reexposure to a specific antigen and requires the release of proinflammatory mediators. Anaphylactoid reactions occur through a direct non-immunoglobulin E-mediated release of mediators from mast cells or from complement activation. Muscle relaxants and latex account for most cases of anaphylaxis during the perioperative period. Symptoms may include all organ systems and present with bronchospasm and cardiovascular collapse in the most severe cases. Management of anaphylaxis includes discontinuation of the presumptive drug (or latex) and anesthetic, aggressive pulmonary and cardiovascular support, and epinephrine. Although a serum tryptase confirms the diagnosis of an anaphylactic reaction, the offending drug can be identified by skin-prick, intradermal testing, or serologic testing. Prevention of recurrences is critical to avoid mortality and morbidity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Evaluation of Diagnostic Criteria for Ankylosing Spondylitis
Linden, S. V. D., Valkenburg, H. A., & Cats, A. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780270401 · Cited by 5,697
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
Sampson, H. A., Mendelson, L., & Rosen, J. P. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208063270603 · Cited by 1,609 · cited 1×
“Failure to recognize anaphylaxis and treat it promptly with epinephrine may result in biphasic or protracted anaphylaxis or in a fatal outcome (29,30).”
BackgroundAgonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Steinhoff, M., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., et al. (2000) · Nature Medicine · doi:10.1038/72247 · Cited by 936
Molecular cloning of a potential proteinase activated receptor.
Nystedt, S., Emilsson, K., Wahlestedt, C., & Sundelin, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9208 · Cited by 886
Feldtkeller, E., Khan, M., van der Heijde, D., van der Linden, S., & Braun, J. (2003) · Rheumatology International · doi:10.1007/s00296-002-0237-4 · Cited by 859
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis
Schwartz, L. B., Metcalfe, D. D., Miller, J. S., Earl, H., & Sullivan, T. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706253162603 · Cited by 784
Amniotic fluid embolism: Analysis of the national registry
Clark, S. L., Hankins, G. D. V., Dudley, D. A., Dildy, G. A., & Porter, T. F. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91474-9 · Cited by 703
Braun, J., Bollow, M., Neure, L., Seipelt, E., Seyrekbasan, F., Herbst, H., Eggens, U., Distler, A., & Sieper, J. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380407 · Cited by 690
Anaphylactic and Anaphylactoid Reactions Occurring during Anesthesia in France in 1999–2000
Mertes, P. M., Laxenaire, M.-C., & Alla, F. (2003) · Anesthesiology · doi:10.1097/00000542-200309000-00007 · Cited by 542
Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells.
Schwartz, L. B., Irani, A. M. A., Roller, K., Castells, M. C., & Schechter, N. M. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.8.2611 · Cited by 500
Self-citation
Cited by
Sampson, H. A., Muñoz-Furlong, A., Campbell, R. L., Adkinson, N. F., Bock, S. A., Branum, A., Brown, S. G. A., Camargo, C. A., Cydulka, R., Galli, S. J., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1303 · Cited by 2,313
Self-citationSampson, H. A., Muñoz-Furlong, A., Campbell, R. L., Adkinson, N. F., Allan Bock, S., Branum, A., Brown, S. G. A., Camargo, C. A., Cydulka, R., Galli, S. J., et al. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.01.018 · Cited by 748
Self-citationSymposium on the Definition and Management of Anaphylaxis: Summary report
Sampson, H. A., Muñoz-Furlong, A., Bock, S. A., Schmitt, C., Bass, R., Chowdhury, B. A., Decker, W. W., Furlong, T. J., Galli, S. J., Golden, D. B., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.01.009 · Cited by 641
Self-citation
Metadata
- Authors
- Hepner, D. L., & Castells, M. C.
- Venue
- Anesthesia & Analgesia
- Published
- 2003-11
- Volume
- 97
- Issue
- 5
- Pages
- 1381-1395
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2164623742
- Cited by
- 375
- References
- 127
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Anaphylaxis During the Perioperative Period. https://app.cochat.ai/papers/10.1213/01.ane.0000082993.84883.7d
- The paper
- Hepner, D. L., & Castells, M. C. (2003). Anaphylaxis During the Perioperative Period. Anesthesia & Analgesia. https://doi.org/10.1213/01.ane.0000082993.84883.7d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
