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Cited by 219Hemodynamic Monitoring and TherapyHealthcare Technology and Patient MonitoringCardiac, Anesthesia and Surgical Outcomes

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Ability of an arterial waveform analysis-derived hypotension prediction index to predict future hypotensive events in surgical patients

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Davies, Simon James, Vistisen, Simon Tilma, Jian, Zhongping, Hatib, Feras, Scheeren, Thomas W. L.·2020·Anesthesia & Analgesia
DOI 10.1213/ane.0000000000004121
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Abstract

BACKGROUND: Intraoperative hypotension is associated with worse perioperative outcomes for patients undergoing major noncardiac surgery. The Hypotension Prediction Index is a unitless number that is derived from an arterial pressure waveform trace, and as the number increases, the risk of hypotension occurring in the near future increases. We investigated the diagnostic ability of the Hypotension Prediction Index in predicting impending intraoperative hypotension in comparison to other commonly collected perioperative hemodynamic variables. METHODS: This is a 2-center retrospective analysis of patients undergoing major surgery. Data were downloaded and analyzed from the Edwards Lifesciences EV1000 platform. Receiver operating characteristic curves were constructed for the Hypotension Prediction Index and other hemodynamic variables as well as event rates and time to event. RESULTS: Two hundred fifty-five patients undergoing major surgery were included in the analysis yielding 292,025 data points. The Hypotension Prediction Index predicted hypotension with a sensitivity and specificity of 85.8% (95% CI, 85.8%–85.9%) and 85.8% (95% CI, 85.8%–85.9%) 5 minutes before a hypotensive event (area under the curve, 0.926 [95% CI, 0.925–0.926]); 81.7% (95% CI, 81.6%–81.8%) and 81.7% (95% CI, 81.6%–81.8%) 10 minutes before a hypotensive event (area under the curve, 0.895 [95% CI, 0.894–0.895]); and 80.6% (95% CI, 80.5%–80.7%) and 80.6% (95% CI, 80.5%–80.7%) 15 minutes before a hypotensive event (area under the curve, 0.879 [95% CI, 0.879–0.880]). The Hypotension Prediction Index performed superior to all other measured hemodynamic variables including mean arterial pressure and change in mean arterial pressure over a 3-minute window. CONCLUSIONS: The Hypotension Prediction Index provides an accurate real time and continuous prediction of impending intraoperative hypotension before its occurrence and has superior predictive ability than the commonly measured perioperative hemodynamic variables.

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Metadata

Authors
Davies, S. J., Vistisen, S. T., Jian, Z., Hatib, F., & Scheeren, T. W. L.
Affiliations
  • National Health Service (GB)
  • Aarhus University (DK)
  • Edwards Lifesciences (United States) (US)
  • University Medical Center Groningen (NL)
Corresponding author
Davies, Simon James
ORCID
Venue
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-02
Volume
130
Issue
2
Pages
352-359
ISSN
0003-2999 (ISSN-L)
DOI
10.1213/ane.0000000000004121
OpenAlex
W2928352011
Cited by
219
References
23
Citations by year
2026: 26 · 2025: 29 · 2024: 42 · 2023: 33 · 2022: 28 · 2021: 30 · 2020: 24
FWCI
21.44
Type
journal article
Language
en
Update notices
correction (2023-09-01)
Open access
Licence
other-oa
Locations
  • Anesthesia & Analgesia (publishedVersion)
  • PubMed (publishedVersion)
  • Scopus (Elsevier) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders
Edwards Lifesciences
Topics
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Surgery › Healthcare Technology and Patient Monitoring
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
Keywords
Hypotension Prediction Index, intraoperative hypotension, arterial waveform analysis, non-cardiac surgery, hemodynamic monitoring, hypotension prediction, mean arterial pressure, perioperative outcomes, sensitivity and specificity, time-to-event prediction
MeSH terms
Aged, Aged, 80 and over, Female, Forecasting, Humans, Hypotension, Intraoperative Complications, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Retrospective Studies, Monitoring, Intraoperative, Arterial Pressure

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