The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Ancestral Inference in Population Genetics
Open accessAbstract
Mitochondrial DNA sequence variation is now being used to study the history of our species. In this paper we discuss some aspects of estimation and inference that arise in the study of such variability, focusing in particular on the estimation of substitution rates and their use in calibrating estimates of the time since the most recent common ancestor of a sample of sequences. Observed DNA sequence variation is generated by superimposing the effects of mutation on the ancestral tree of the sequences. For data of the type studied here, this ancestral tree has to be modeled as a random process. Superimposing the effects of mutation produces complicated sampling distributions that form the basis of any statistical model for the data. Using such distributions--for example, for maximum likelihood estimation of rates--poses some difficult computational problems. We describe a Monte Carlo method, a cousin of the popular "Markov chain Monte Carlo," that has proved very useful in addressing some of these issues.
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Cites
Monte Carlo sampling methods using Markov chains and their applications.
Hastings, W. K. (1970) · Biometrika · doi:10.1093/biomet/57.1.97 · Cited by 15,195
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Felsenstein, J. (1981) · Journal of Molecular Evolution · doi:10.1007/bf01734359 · Cited by 14,571
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EVOLUTION IN MENDELIAN POPULATIONS
Wright, S. (1931) · Genetics · doi:10.1093/genetics/16.2.97 · Cited by 8,916
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(1995) · Chapman & Hall/CRC eBooks · doi:10.1201/b14835 · Cited by 7,757
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On the number of segregating sites in genetical models without recombination
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Cited by
Population growth of human Y chromosomes: a study of Y chromosome microsatellites
Pritchard, J. K., Seielstad, M. T., Perez-Lezaun, A., & Feldman, M. W. (1999) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026091 · Cited by 1,080
Drummond, A. J., Nicholls, G. K., Rodrigo, A. G., & Solomon, W. (2002) · Genetics · doi:10.1093/genetics/161.3.1307 · Cited by 1,059
Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
Rosenberg, N. A., & Nordborg, M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg795 · Cited by 750
Properties of statistical tests of neutrality for DNA polymorphism data
Simonsen, K. L., Churchill, G. A., & Aquadro, C. F. (1995) · Genetics · doi:10.1093/genetics/141.1.413 · Cited by 681
The application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 676
Metadata
- Authors
- Griffiths, R. C., & Tavare, S.
- Venue
- Statistical Science
- Publisher
- Institute of Mathematical Statistics
- Published
- 1994-08-01
- Volume
- 9
- Issue
- 3
- ISSN
- 0883-4237 (ISSN-L)
- OpenAlex
- W1980674207
- Cited by
- 388
- References
- 56
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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