Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
Abstract
Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.
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Significant effort has been dedicated to understanding protein sequences as emerging from tree-structured evolutionary processes over time or coalescent processes in reverse time.
“However, significant effort has been dedicated to understanding protein sequences as emerging from tree-structured evolutionary processes over time or coalescent processes in reverse time 90,91.”
From Learning the protein language: Evolution, structure, and function (2021) · cites this paper as [91]
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- Authors
- Rosenberg, N. A., & Nordborg, M.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Nordborg, Magnus
- Venue
- Nature Reviews Genetics
- Published
- 2002-05
- Volume
- 3
- Issue
- 5
- Pages
- 380-390
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2114058116
- Cited by
- 750
- References
- 110
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 50 · 2021: 24 · 2020: 23 · 2019: 33 · 2018: 60 · 2017: 41 · 2016: 33 · 2015: 31 · 2014: 49 · 2013: 32 · 2012: 33
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- genealogical trees, coalescent theory, genetic polymorphism, population genetics, migration, natural selection, genotyping, stochastic processes, evolutionary history
- MeSH terms
- Animals, Genetics, Population, Humans, Pedigree, Polymorphism, Genetic, Recombination, Genetic, Stochastic Processes, Evolution, Molecular
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