Cited by 751Genetic diversity and population structureForensic and Genetic ResearchEvolution and Genetic Dynamics

Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

Rosenberg, Noah A., Nordborg, Magnus·2002·Nature Reviews Genetics

Abstract

Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

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Crossref · 10.1038/nrg795

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  • Significant effort has been dedicated to understanding protein sequences as emerging from tree-structured evolutionary processes over time or coalescent processes in reverse time.

    “However, significant effort has been dedicated to understanding protein sequences as emerging from tree-structured evolutionary processes over time or coalescent processes in reverse time 90,91.”

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Authors
Rosenberg, N. A., & Nordborg, M.
Affiliations
University of Southern California (US)
Corresponding author
Nordborg, Magnus
Venue
Nature Reviews Genetics
Published
2002-05
Volume
3
Issue
5
Pages
380-390
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2114058116
Cited by
750
References
110
Citations by year
2026: 6 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 50 · 2021: 24 · 2020: 23 · 2019: 33 · 2018: 60 · 2017: 41 · 2016: 33 · 2015: 31 · 2014: 49 · 2013: 32 · 2012: 33
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
genealogical trees, coalescent theory, genetic polymorphism, population genetics, migration, natural selection, genotyping, stochastic processes, evolutionary history
MeSH terms
Animals, Genetics, Population, Humans, Pedigree, Polymorphism, Genetic, Recombination, Genetic, Stochastic Processes, Evolution, Molecular

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