The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Dynamics of Intraventricular Hemorrhage in Patients with Spontaneous Intracerebral Hemorrhage: Risk Factors, Clinical Impact, and Effect of Hemostatic Therapy with Recombinant Activated Factor VII
Abstract
OBJECTIVE: To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH). METHODS: We analyzed 374 patients out of 399 who were randomized to rFVIIa (40, 80, or 160 mug/kg) or placebo for ICH (diagnosed within 3 h of symptoms). Risk factors for IVH growth (>2 ml increase in IVH volume at 24 h), and death or severe disability (modified Rankin scale score 4-6) at 3 months were identified (logistic regression). RESULTS: IVH was present in 38% (n = 141) of patients at baseline and 45% (n = 169) by 24 hours. IVH growth, by 24 hours, occurred in 17 and 10% of placebo- and rFVIIa-treated patients, respectively (P = 0.037). Risk factors for IVH growth included baseline mean arterial pressure greater than 120 mmHg, larger baseline ICH volume, IVH present at baseline, shorter time from symptom onset to baseline computed tomographic scan, and treatment (rFVIIa versus placebo) (all, P < or = 0.037). Predictors of death or severe disability included older age, lower baseline Glasgow Coma Score, larger baseline ICH volume, IVH growth greater than 2 ml, IVH present at baseline or 24 hours, and treatment (rFVIIa versus placebo) (all, P < or = 0.0405). CONCLUSION: Presence of IVH at any time and early IVH growth worsen clinical outcome and increase mortality. Elevated mean arterial pressure at baseline may be a modifiable risk factor for IVH growth. Beneficial effects of rFVIIa on ICH outcome may be mediated, at least in part, by reducing IVH growth.
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Cites
The ICH Score: A Simple, Reliable Grading Scale for Intracerebral Hemorrhage
Hemphill, J. C., Bonovich, D. C., Besmertis, L., Manley, G. T., & Johnston, S. C. (2001) · Stroke · doi:10.1161/01.str.32.4.891 · Cited by 2,196
Mendelow, A. D., GREGSON, B. A., Fernandes, H. M., Murray, G. D., Teasdale, G. M., Hope, D., Karimi, A., Shaw, M. D. M., & Barer, D. H. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17826-x · Cited by 1,996
Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality.
Broderick, J. P., Brott, T. G., Duldner, J. E., Tomsick, T., & Huster, G. (1993) · Stroke · doi:10.1161/01.str.24.7.987 · Cited by 1,746
Self-citationEarly Hemorrhage Growth in Patients With Intracerebral Hemorrhage
Brott, T., Broderick, J., Kothari, R., Barsan, W., Tomsick, T., Sauerbeck, L., Spilker, J., Duldner, J., & Khoury, J. (1997) · Stroke · doi:10.1161/01.str.28.1.1 · Cited by 1,477
Self-citationHematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
Davis, S. M., Broderick, J., Hennerici, M., Brun, N. C., Diringer, M. N., Mayer, S. A., Begtrup, K., & Steiner, T. (2006) · Neurology · doi:10.1212/01.wnl.0000208408.98482.99 · Cited by 1,168
Self-citationRecombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., Skolnick, B. E., & Steiner, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042991 · Cited by 1,167
Self-citationRecombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A. (2007) · Stroke · doi:10.1161/01.str.0000254499.46122.22 · Cited by 1,034
Self-citationBroderick, J. P., Adams, H. P., Barsan, W., Feinberg, W., Feldmann, E., Grotta, J., Kase, C., Krieger, D., Mayberg, M., Tilley, B., et al. (1999) · Stroke · doi:10.1161/01.str.30.4.905 · Cited by 830
Self-citationEnlargement of Spontaneous Intracerebral Hemorrhage: Incidence and Time Course
Kazui, S., Naritomi, H., Yamamoto, H., Sawada, T., & Yamaguchi, T. (1996) · Stroke · doi:10.1161/01.str.27.10.1783 · Cited by 572
Early neurologic deterioration in intracerebral hemorrhage: Predictors and associated factors
Leira, R., Dávalos, A., Silva, Y., Gil-Peralta, A., Tejada, J., Garcia, M., & Castillo, J. (2004) · Neurology · doi:10.1212/01.wnl.0000133204.81153.ac · Cited by 498
Cited by
Qureshi, A. I., Mendelow, A. D., & Hanley, D. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60371-8 · Cited by 1,526
Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., Skolnick, B. E., & Steiner, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707534 · Cited by 1,255
Self-citation(2006) · Cerebrovascular Diseases · doi:10.1159/000094831 · Cited by 411
Metadata
- Authors
- Steiner, T., Diringer, M. N., Schneider, D., Mayer, S. A., Begtrup, K., Broderick, J., Skolnick, B. E., & Davis, S. M.
- Venue
- Neurosurgery
- Published
- 2006-10
- Volume
- 59
- Issue
- 4
- Pages
- 767-774
- ISSN
- 0148-396X (ISSN-L)
- OpenAlex
- W1965069494
- Cited by
- 275
- References
- 23
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Steiner, T., Diringer, M. N., Schneider, D., Mayer, S. A., Begtrup, K., Broderick, J., Skolnick, B. E., & Davis, S. M. (2006). Dynamics of Intraventricular Hemorrhage in Patients with Spontaneous Intracerebral Hemorrhage: Risk Factors, Clinical Impact, and Effect of Hemostatic Therapy with Recombinant Activated Factor VII. Neurosurgery. https://doi.org/10.1227/01.neu.0000232837.34992.32
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