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Emerging Histomorphologic Phenotypes of Chronic Traumatic Encephalopathy in American Athletes
Abstract
BACKGROUND: We define chronic traumatic encephalopathy (CTE) as a progressive neurodegenerative syndrome caused by single, episodic, or repetitive blunt force impacts to the head and transfer of acceleration-deceleration forces to the brain. OBJECTIVE: We present emerging histomorphologic phenotypes of CTE that we identified in our cohort of CTE cases with apolipoprotein E genotyping and causes and manners of death. METHODS: Autopsy brain tissue of 14 professional athletes and 3 high school football players was examined after unexpected deaths. Histochemical and immunohistochemical tissue staining was performed with apolipoprotein E genotyping. RESULTS: Ten of 14 professional athletes (71%) were positive for CTE: 7 of 8 football players, 2 of 4 wrestlers, and 1 boxer. One of 3 high school players manifested incipient CTE. The age range of those with CTE was 18 to 52 years; they were all male athletes. In all cases of CTE, Alzheimer-type cerebral cortical atrophy was absent; negligible to mild neocortical neuronal dropout was present. The fundamental neuropathologic feature of CTE was the topographic distribution of sparse, moderate, and frequent band-shaped, flame-shaped, small and large globose neurofibrillary tangles and neuritic threads in the cerebral cortex, subcortical nuclei/basal ganglia, hippocampus, and brainstem nuclei. Sparse to frequent diffuse amyloid plaques may accompany tauopathy and was seen in only 2 CTE cases. No α-synucleinopathy was present. All 7 CTE-positive professional athletes with known apolipoprotein E genotypes had at least 1 E3 allele comprising 5 E3/E3 (71%) and 2 E3/E4 (29%). Alcohol- and drug-related deaths, suicides, and accidental deaths were overrepresented in our CTE cohort. CONCLUSION: The emerging histomorphologic features of our CTE cohort may specify histologic criteria for CTE diagnosis, may identify emerging histologic variants of CTE and may facilitate more objective surveillance and accurate identification of sentinel CTE cases.
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In the citing paper
“Prior to 2015, there were no agreed upon neuropathological criteria for CTE, and the criteria put forward by the two research groups in the US differed [15, 16].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [15]
In the citing paper
“The consensus panel did not adopt the four neuropathological phenotypes [15] or stages of CTE [16], and indicated that the preliminary criteria were a “first step along the path to standardizing the neuropathology of CTE” [30].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [15]
In the citing paper
“Over the past decade, the clinical features attributed to CTE have been expanded greatly and include virtually any mental health or neurological symptom or problem present prior to death”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [15]
In the citing paper
“Prior to 2016, there were no agreed upon neuropathological criteria for CTE, and the criteria published by the 2 leading research groups in the United States differed substantially (7,14).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [7]
In the citing paper
“In different autopsy series, the percentage of former professional American football players who have died and donated their brains to research varies from 50 % [88], 80 % [146], to 97 %) [128].”
From The neuropathology of sport (2014) · cites this paper as [146]
In the citing paper
“Although CTE was first identified in association with boxing, CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player (Figs. 3, 4, 5, 6) [38, 65, 66, 88, 91, 127, 128, 146–148].”
From The neuropathology of sport (2014) · cites this paper as [146]
Citations
Cites
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
MARTLAND, H. S. (1928) · Journal of the American Medical Association · doi:10.1001/jama.1928.02700150029009 · Cited by 774
Chronic Traumatic Encephalopathy in a National Football League Player
Kelly, D. F. (2006) · Neurosurgery · doi:10.1097/00006123-200605000-00037 · Cited by 694
Association of apolipoprotein E polymorphism with outcome after head injury
Teasdale, G. M., Nicoll, J. A. R., Murray, G. D., & Fiddes, M. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04318-3 · Cited by 683
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing
Jordan, B. D. (1997) · JAMA · doi:10.1001/jama.278.2.136 · Cited by 665
Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995) · Neurology · doi:10.1212/wnl.45.3.555 · Cited by 590
Love, S., Louis, D. N., & Ellison, D. W. (2008) · CRC Press eBooks · doi:10.1201/b22602 · Cited by 445
Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury
Friedman, G., Froom, P., Sazbon, L., Grinblatt, I., Shochina, M., Tsenter, J., Babaey, S., Yehuda, A. B., & Groswasser, Z. (1999) · Neurology · doi:10.1212/wnl.52.2.244 · Cited by 437
Traumatic Brain Injury — Football, Warfare, and Long-Term Effects
DeKosky, S. T., Ikonomović, M. D., & Gandy, S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1007051 · Cited by 322
Chronic traumatic encephalopathy (CTE) in a National Football League Player
Omalu, B. I., Hamilton, R. L., Kamboh, M. I., DeKosky, S. T., & Bailes, J. E. (2010) · Journal of Forensic Nursing · doi:10.1111/j.1939-3938.2009.01064.x · Cited by 260
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Flagged first, then by citations
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Items 101–200 of 381
Models of Mild Traumatic Brain Injury
Petraglia, A. L., Dashnaw, M. L., Turner, R. C., & Bailes, J. E. (2014) · Neurosurgery · doi:10.1227/neu.0000000000000472 · Cited by 66
Self-citationFrom the Field of Play to the Field of Combat
Petraglia, A. L., Maroon, J. C., & Bailes, J. E. (2012) · Neurosurgery · doi:10.1227/neu.0b013e31824cebe8 · Cited by 63
Self-citationTraumatic brain injury: Changing concepts and approaches
Maas, A. I. R. (2016) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2016.01.001 · Cited by 62
Mavroudis, I. A., Kazis, D. A., Chowdhury, R., Petridis, F., Costa, V., Balmuș, I.-M., Ciobica, A. S., Luca, A.-C., Radu, I., Dobrin, R., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12030740 · Cited by 65
Chronic traumatic encephalopathy and athletes
Meehan, W. P., III, Mannix, R., ZAFONTE, R. D., & Pascual‐Leone, Á. (2015) · Neurology · doi:10.1212/wnl.0000000000001893 · Cited by 63
Altered Blood Biomarker Profiles in Athletes with a History of Repetitive Head Impacts
Battista, A. P. D., Rhind, S. G., Richards, D. W., Churchill, N. W., BAKER, A. J., & Hutchison, M. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159929 · Cited by 62
Aging, Neurodegenerative Disease, and Traumatic Brain Injury: The Role of Neuroimaging
Esopenko, C., & Levine, B. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3506 · Cited by 60
Larrabee, G. J., Binder, L. M., Rohling, M. L., & Ploetz, D. M. (2013) · The Clinical Neuropsychologist · doi:10.1080/13854046.2013.769634 · Cited by 60
Chronic traumatic encephalopathy and other neurodegenerative proteinopathies
Tartaglia, M. C., Hazrati, L., Davis, K. D., Green, R., Wennberg, R. A., Mikulis, D. J., Ezerins, L., Keightley, M., & Tator, C. H. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00030 · Cited by 64
Modern Chronic Traumatic Encephalopathy in Retired Athletes: What is the Evidence?
Karantzoulis, S., & RANDOLPH, C. C. (2013) · Neuropsychology Review · doi:10.1007/s11065-013-9243-4 · Cited by 58
Ojo, J. O., Algamal, M., Leary, P., Abdullah, L. I., Mouzon, B., Evans, J. E., MULLAN, M. J., & Crawford, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00103 · Cited by 59
Wagner, A. K., & Zitelli, K. T. (2012) · Pathophysiology · doi:10.1016/j.pathophys.2012.02.007 · Cited by 54
Shively, S. B., Edgerton, S. L., Iacono, D., Purohit, D. P., Qu, B.-X., Haroutunian, V., Davis, K. L., Diaz-Arrastia, R., & Perl, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1649-7 · Cited by 52
Jarrett, M., Tam, R. C., Hernández‐Torres, E., Martin, N., Perera, W. R., Zhao, Y., Shahinfard, E., Dadachanji, S. B., Taunton, J., Li, D. K. B., et al. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00011 · Cited by 52
Sports-related concussions: diagnosis, complications, and current management strategies
Hobbs, J. G., Young, J. S., & Bailes, J. E. (2016) · Neurosurgical FOCUS · doi:10.3171/2016.1.focus15617 · Cited by 55
Self-citationZhao, Z., Zhao, Y., Ning, Y.-L., Yang, N., Peng, Y., Li, P., Chen, X.-Y., Liu, D., Wang, H., Chen, X., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.98 · Cited by 55
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample
Postupna, N. O., Rose, S. E., Gibbons, L. E., Coleman, N., Hellstern, L. L., Ritchie, K., Wilson, A. M., Cudaback, E., Li, X., Melief, E. J., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.624696 · Cited by 51
Chronic traumatic encephalopathy in sports: a historical and narrative review
Solomon, G. S. (2018) · Developmental Neuropsychology · doi:10.1080/87565641.2018.1447575 · Cited by 52
Bigler, E. D., Farrer, T. J., Pertab, J. L., James, K. M., Petrie, J. A., & Hedges, D. W. (2013) · The Clinical Neuropsychologist · doi:10.1080/13854046.2012.693950 · Cited by 57
A time-course analysis of changes in cerebral metal levels following a controlled cortical impact
Portbury, S. D., Hare, D. J., Sgambelloni, C., Finkelstein, D. I., & Adlard, P. A. (2015) · Metallomics · doi:10.1039/c5mt00234f · Cited by 49
Alexander, D., Shuttleworth-Edwards, A. B., Kidd, M., & Malcolm, C. M. (2015) · Brain Injury · doi:10.3109/02699052.2015.1031699 · Cited by 54
Chronic traumatic encephalopathy and suicide: A systematic review
Wortzel, H. S., Shura, R. D., & Brenner, L. A. (2013) · BioMed Research International · doi:10.1155/2013/424280 · Cited by 47
White, D. L., Kunik, M. E., Yu, H. Q., Lin, H., Richardson, P., Moore, S., Sarwar, A., Marsh, L., & Jorge, R. E. (2020) · Annals of Neurology · doi:10.1002/ana.25726 · Cited by 48
Davis, G. A., Castellani, R. J., & McCrory, P. (2015) · Neurosurgery · doi:10.1227/neu.0000000000000722 · Cited by 47
Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort
Walt, G. S., Burris, H. M., Brady, C. B., Spencer, K. R., Alvarez, V. E., Huber, B. R., Guilderson, L., Abdul Rauf, N., Collins, D., Singh, T., et al. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly092 · Cited by 45
Naeser, M. A., Martin, P. I., Ho, M. D., Krengel, M., Bogdanova, Y., Knight, J., Hamblin, M. R., Fedoruk, A., Poole, L. G., Cheng, C.-H., et al. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220022 · Cited by 46
Trehalose improves traumatic brain injury-induced cognitive impairment
Portbury, S. D., Hare, D. J., Finkelstein, D. I., & Adlard, P. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183683 · Cited by 46
Automated versus manual segmentation of brain region volumes in former football players
Guenette, J. P., Stern, R. A., Tripodis, Y., Chua, A. S., Schultz, V., Sydnor, V. J., Somes, N., Karmacharya, S., Lepage, C., Wróbel, P., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.03.026 · Cited by 45
The long-term outcomes of sport-related concussion in pediatric populations.
Moore, R., Kay, J. J. M., & Ellemberg, D. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.04.003 · Cited by 31
Late-stage CTE pathology in a retired soccer player with dementia
Hales, C. M., Neill, S. G., Gearing, M., Cooper, D., Glass, J., & Lah, J. J. (2014) · Neurology · doi:10.1212/wnl.0000000000001081 · Cited by 46
Wang, K., Pareja, J. C. M., Mondello, S., Diaz-Arrastia, R. R., Wellington, C. L., Kenney, K., Puccio, A. M., Hutchison, J. S., McKinnon, N. K., Okonkwo, D. O., et al. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.2005583 · Cited by 49
Sundman, M., Doraiswamy, P. M., & Morey, R. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00334 · Cited by 46
Savjani, R. R., Taylor, B. A., Ación, L., Wilde, E. A., & Jorge, R. E. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5022 · Cited by 42
Willeumier, K. C., Taylor, D. V., & Amen, D. (2012) · Translational Psychiatry · doi:10.1038/tp.2011.67 · Cited by 42
Recent developments in clinical trials for the treatment of traumatic brain injury
Stein, D. G., Geddes, R. I., & Sribnick, E. A. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52892-6.00028-3 · Cited by 46
Chronic traumatic encephalopathy: the dangers of getting "dinged"
Lakhan, S. E., & Kirchgessner, A. L. (2012) · SpringerPlus · doi:10.1186/2193-1801-1-2 · Cited by 45
Bibliometric Analysis of Chronic Traumatic Encephalopathy Research from 1999 to 2019
Qi, B., Jin, S., Qian, H., & Zou, Y. F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155411 · Cited by 42
Schwab, N., Wennberg, R. A., Grenier, K., Tartaglia, M. C., Tator, C. H., & Hazrati, L. (2021) · Neurology · doi:10.1212/wnl.0000000000011668 · Cited by 42
Chronic Effects of Mild Neurotrauma: Putting the Cart Before the Horse?
Castellani, R. J., Perry, G., & Iverson, G. L. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000193 · Cited by 40
Su, E. R., & Bell, M. J. (2015) · Frontiers in neuroscience · doi:10.1201/b18959-4 · Cited by 40
MRI Evidence of Neuropathic Changes in Former College Football Players
Adler, C. M., DelBello, M. P., Weber, W., Williams, M., Durán, L. R. P., Fleck, D. E., Boespflug, E. L., Eliassen, J. C., Strakowski, S. M., & Divine, J. G. (2016) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000391 · Cited by 39
Hashtag #TBI: A content and network data analysis of tweets about Traumatic Brain Injury
Brunner, M., Hemsley, B., Dann, S., Togher, L., & Palmer, S. R. (2017) · Brain Injury · doi:10.1080/02699052.2017.1403047 · Cited by 39
Chronic Traumatic Encephalopathy in Professional American Football Players: Where Are We Now?
Tharmaratnam, T., Iskandar, M. M. A., Tabobondung, T., Tobbia, I., Gopee‐Ramanan, P., & Tabobondung, T. A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00445 · Cited by 44
The Biological Basis of Chronic Traumatic Encephalopathy following Blast Injury: A Literature Review
Aldag, M., Armstrong, R. C., Bandak, F. A., Bellgowan, P. S. F., Bentley, T. B., Biggerstaff, S., Caravelli, K., Cmarik, J. L., Crowder, A. T., DeGraba, T. J., et al. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5218 · Cited by 40
Rubenstein, R., Sharma, D. R., Chang, B., Oumata, N., Cam, M., Vaucelle, L., Lindberg, M. F., Chiu, A., Wısnıewskı, T., Wang, K., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00124 · Cited by 38
Epidemiology of neurodegeneration in American-style professional football players
Lehman, E. J. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt188 · Cited by 39
Ge, X., Yu, J., HUANG, S. H., Yin, Z., Han, Z., Chen, F., Wang, Z., Zhang, J., & Lei, P. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.07.021 · Cited by 37
Mao, X., Terpolilli, N. A., Wehn, A. C., Cheng, S., Hellal, F., Liu, B., Şeker, F. B., & Plesnila, N. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6510 · Cited by 41
Psychiatric phenotypes in chronic traumatic encephalopathy
Mahar, I., Alosco, M. L., & McKee, A. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.023 · Cited by 36
PET and Single-Photon Emission Computed Tomography in Brain Concussion.
Raji, C. A., & Henderson, T. A. (2018) · Neuroimaging clinics of North America · doi:10.1016/j.nic.2017.09.003 · Cited by 37
Traumatic Brain Injury and Chronic Traumatic Encephalopathy: A Forensic Neuropsychiatric Perspective
Wortzel, H. S., Brenner, L. A., & Arciniegas, D. B. (2013) · Behavioral Sciences & the Law · doi:10.1002/bsl.2079 · Cited by 36
The Impact of Traumatic Brain Injury on the Aging Brain
Young, J. S., Hobbs, J. G., & Bailes, J. E. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0719-9 · Cited by 36
Self-citationKomura, A., Kawasaki, T., Yamada, Y., Uzuyama, S., Asano, Y., & Shinoda, J. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5641 · Cited by 35
The Current Status of Research on Chronic Traumatic Encephalopathy
Perrine, K. R., Helcer, J., Tsiouris, A. J., Pisapia, D. J., & Stieg, P. E. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.02.084 · Cited by 37
Ojo, J. O., Algamal, M., Leary, P., Abdullah, L. I., Mouzon, B., Evans, J. E., MULLAN, M. J., & Crawford, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00893 · Cited by 34
Ameen‐Ali, K. E., Bretzin, A. C., Lee, E. B., Folkerth, R. D., Hazrati, L., Iacono, D., Keene, C. D., Kofler, J., Kovács, G. G., Nolan, A., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01353-4 · Cited by 34
Chronic traumatic encephalopathy in professional sports: Retrospective and prospective views
Solomon, G. S., & Zuckerman, S. L. (2014) · Brain Injury · doi:10.3109/02699052.2014.965205 · Cited by 34
Sports-related brain injuries: connecting pathology to diagnosis
Pan, J., Connolly, I. D., Dangelmajer, S., Kintzing, J. R., Ho, A. L., & Grant, G. A. (2016) · Neurosurgical FOCUS · doi:10.3171/2016.1.focus15607 · Cited by 35
Sharma, A., Hind, K., Hume, P. A., Singh, J., & Neary, J. P. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00042 · Cited by 32
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Lakis, N. S., Corona, R. J., Toshkezi, G., & Chin, L. S. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000177 · Cited by 33
Mayilsamy, K., Markoutsa, E., Das, M., Chopade, P., Puro, D., Kumar, A., Gulick, D., Willing, A. E., Mohapatra, S. S., & Mohapatra, S. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102247 · Cited by 31
Riley, D., Robbins, C. A., Cantu, R. C., & Stern, R. A. (2015) · Brain Injury · doi:10.3109/02699052.2014.965215 · Cited by 32
Mufson, E. J., Perez, S. E., Nadeem, M., Mahady, L. J., Kanaan, N. M., Abrahamson, E. E., Ikonomović, M. D., Crawford, F., Alvarez, V. E., Stein, T. D., et al. (2016) · Brain Injury · doi:10.1080/02699052.2016.1219058 · Cited by 31
Risk of Misdiagnosing Chronic Traumatic Encephalopathy in Men With Depression
Iverson, G. L., & Gardner, A. J. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19010021 · Cited by 30
Modeling sports‐related mild traumatic brain injury in animals—A systematic review
Hiskens, M. I., Angoa‐Pérez, M., Schneiders, A. G., Vella, R. K., & Fenning, A. S. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24472 · Cited by 32
CCL5 is essential for axonogenesis and neuronal restoration after brain injury
Ho, M.-H., Tsai, Y., Chen, C.-Y., Yang, A., Burnouf, T., Wang, Y., Chiang, Y. H., Hoffer, B. J., & Chou, S. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01083-w · Cited by 29
Novgorodov, S., Voltin, J. R., Wang, W., Tomlinson, S., Riley, C. L., & Gudz, T. I. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m091132 · Cited by 20
Symptoms of traumatic encephalopathy syndrome are common in the US general population
Iverson, G. L., & Gardner, A. J. (2021) · Brain Communications · doi:10.1093/braincomms/fcab001 · Cited by 30
Chronic Traumatic Encephalopathy and Neurodegeneration in Contact Sports and American Football
Zuckerman, S. L., Brett, B. L., Jeckell, A. S., Yengo-Kahn, A. M., & Solomon, G. S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180218 · Cited by 30
Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma
Ojo, J. O., Eisenbaum, M., Shackleton, B., Lynch, C., Joshi, U., Saltiel, N. A., Pearson, A., Ringland, C., Paris, D., Mouzon, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105237 · Cited by 30
Management and Prevention of Sport-Related Concussion
Hanson, E., Stracciolini, A., Mannix, R., & Meehan, W. P., III (2014) · Clinical Pediatrics · doi:10.1177/0009922813518429 · Cited by 31
Chronic Traumatic Encephalopathy in Athletes Involved with High-impact Sports.
Safinia, C., Bershad, E. M., Clark, H. B., SantaCruz, K. S., Alakbarova, N., Suárez, J. I., & Divani, A. A. (2016) · Journal of vascular and interventional neurology · Cited by 29
Retired National Football League Players are Not at Greater Risk for Suicide
Iverson, G. L. (2019) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acz023 · Cited by 30
Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank
McCann, H., Bahar, A. Y., Burkhardt, K., Gardner, A. J., Halliday, G. M., Iverson, G. L., & Shepherd, C. E. (2022) · Brain Communications · doi:10.1093/braincomms/fcac189 · Cited by 29
Causes and Consequences of Sports Concussion
Edwards, J., & Bodle, J. D. (2014) · The Journal of Law Medicine & Ethics · doi:10.1111/jlme.12126 · Cited by 27
Battista, A. P. D., Rhind, S. G., BAKER, A. J., Jetly, R., Debad, J. D., Richards, D. W., & Hutchison, M. G. (2018) · Brain Injury · doi:10.1080/02699052.2018.1432892 · Cited by 27
Portbury, S. D., & Adlard, P. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143048 · Cited by 26
Henry, L. C., Tremblay, S., & Beaumont, L. D. (2016) · The Neuroscientist · doi:10.1177/1073858416651034 · Cited by 26
Interaction of APOE4 alleles and PET tau imaging in former contact sport athletes
Vasilevskaya, A., Taghdiri, F., Burke, C., Tarazi, A., Naeimi, S. A., Khodadadi, M., Goswami, R., Sato, C., Grinberg, M., Moreno, D., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102212 · Cited by 27
Gaetz, M. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.03.023 · Cited by 28
Motor Function in Former Professional Football Players with History of Multiple Concussions
Tarazi, A., Tator, C. H., Wennberg, R. A., Ebraheem, A., Green, R., Colella, B., Saverino, C., Khodadadi, M., Misquitta, K., & Tartaglia, M. C. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5290 · Cited by 30
Chronic traumatic encephalopathy: How serious a sports problem is it?
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Yengo-Kahn, A. M., Johnson, D. J., Zuckerman, S. L., & Solomon, G. S. (2015) · The American Journal of Sports Medicine · doi:10.1177/0363546515580313 · Cited by 24
Metadata
- Authors
- Omalu, B., Bailes, J., Hamilton, R. L., Kamboh, M. I., Hammers, J., Case, M., & Fitzsimmons, R.
- Affiliations
- West Virginia University (US)
- Corresponding author
- Omalu, Bennet
- Fitzsimmons, Robert
- Venue
- Neurosurgery
- Published
- 2011-07
- Volume
- 69
- Issue
- 1
- Pages
- 173-183
- ISSN
- 0148-396X (ISSN-L)
- OpenAlex
- W1985345440
- Cited by
- 381
- References
- 22
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 21 · 2022: 17 · 2021: 18 · 2020: 20 · 2019: 31 · 2018: 30 · 2017: 41 · 2016: 39 · 2015: 44 · 2014: 35 · 2013: 36 · 2012: 16
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- chronic traumatic encephalopathy, histopathology, neurofibrillary tangles, tauopathy, APOE genotype, professional athletes, football players, boxing, wrestling, causes of death, autopsy brain tissue, neurodegeneration
- MeSH terms
- Adolescent, Adult, Americas, Athletic Injuries, Autopsy, Brain, Cause of Death, Humans, Male, Middle Aged, Phenotype, Cohort Studies, Cerebral Amyloid Angiopathy, Neurofibrillary Tangles, Brain Injury, Chronic, Young Adult, Plaque, Amyloid
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