Cited by 443

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B. +1 more·1995·Neurology

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Crossref · 10.1212/wnl.45.3.555

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  • Several studies have suggested that the association between Alzheimer's disease and head injury may be stronger in carriers of the APOE-4 allele.

    “several studies have suggested that this association may be stronger in carriers of the APOE-4 allele (30–32).”
  • Synergistic effects of head injury and APOE genotypes in AD were reported by some studies but not all.

    “Synergistic effects of head injury and APOE genotypes in AD were reported by some (30–32), but not all studies (53;54).”

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Research works printed but not linked: 8

  1. Roberts GW, Gentleman SM, Lynch A, et al. P-Amyloid pro- tein deposition in the brain after severe head injury. J Neurol Neurosurg Psychiatry 1994;57:419-425.
  2. Mayeux R, Ottman R, Tang M-X, et al. Genetic susceptibili- ty and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first- degree relatives. Ann Neurol 1993;33:494-501.
  3. Selkoe DJ. Physiological production of the amyloid P-amy- loid protein and the mechanism of Alzheimer's disease. Trends Neurosci 1993;16:403-409.
  4. Saunders AM, S t r i t t m a t t e r WJ, Schmechel D, e t a l . Association of apolipoprotein E allele €4 with late-onset familial and sporadic Alzheimer's disease. Neurology 5. S t r i t t m a t WJ, S a u n d e r s AM, Schmechel D, e t al. Apolipoprotein E: High affinity binding to beta-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993;90:1977- 1981.
  5. Hixson J , Vernier D. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhAl. J Lipid Res 1991;31:545-548.
  6. Ottman R. An epidemiologic approach to gene-environment interaction. Genet Epidemiol 1990;7: 177-185.
  7. Smith PG, Day NE. The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol 1984;13:356-365.
  8. S t r i t t m a t r WJ, Weisgraber KH, Goedert M, e t al. Hypothesis: microtubule instability and paired helical fila- ment formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 1994;125:163-171. 1993;43:1467-1472. 1991;9:191-195.

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Authors
Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M.
Venue
Neurology
Published
1995-03
Volume
45
Issue
3
Pages
555-557
ISSN
  • 0028-3878
  • 1526-632X
Cited by
443
References
0
Language
en

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