Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes
Open accessAbstract
Varp (VPS9-ankyrin repeat protein) was originally identified as an activator of small GTPase Rab21 through its VPS9 domain, but it has subsequently been shown to function as a Rab32/38 effector through its first ANKR1 domain. Although these functions of Varp are important for melanogenesis, Varp contains a second ANKR2 domain, whose function remained completely unknown. Here we identified Rab40C, an atypical Rab containing a SOCS box that recruits a ubiquitin ligase complex, as a novel ANKR2-binding protein and investigated its involvement in melanogenic enzyme trafficking in melanocytes. The results showed that overexpression of Rab40C in melanocytes caused a dramatic reduction in melanogenic enzyme Tyrp1 signals by promoting proteasomal degradation of Varp in a SOCS-box-dependent manner and that knockdown of Rab40C in melanocytes caused an increase in the amount of Varp. Intriguingly, Rab40C knockdown also caused a dramatic reduction in Tyrp1 signals, the same as Varp overexpression did. These findings indicated that Rab40C is a previously unexpected regulator of Tyrp1 trafficking in melanocytes through controlling the proteasomal degradation of Varp.
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RAB40C has a reported link to the UPS.
“at least one member (RAB40C) has a reported link to the UPS 112 .”
From Targeted protein degradation: expanding the toolbox (2019) · cites this paper as [112]
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- Authors
- Yatsu, A., Shimada, H., Ohbayashi, N., & Fukuda, M.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Ohbayashi, Norihiko
- Fukuda, Mitsunori
- ORCID
- Fukuda, Mitsunori
- Venue
- Biology Open
- Publisher
- The Company of Biologists
- Published
- 2015-02-06
- Volume
- 4
- Issue
- 3
- Pages
- 267-275
- ISSN
- 2046-6390 (ISSN-L)
- PMC
- PMC4359733
- OpenAlex
- W2167885308
- Cited by
- 28
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 3
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biology Open (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (24370077, 15K07039)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- melanocytes, melanogenesis, TRP-1, proteasomal degradation, SOCS box, ubiquitin ligase, protein trafficking, Rab GTPase effectors
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