Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes
Open accessAbstract
Melanosomes are transported to the cell periphery of melanocytes by coordination between bidirectional microtubule-dependent movements and unidirectional actin-dependent movement. Although both the mechanism of the actin-dependent melanosome transport and the mechanism of the microtubule-dependent retrograde melanosome transport in mammalian skin melanocytes have already been determined, almost nothing is known about the mechanism of the microtubule-dependent anterograde melanosome transport. Small GTPase Rab proteins are common regulators of membrane traffic in all eukaryotes, and in this study we performed genome-wide screening for Rab proteins that are involved in anterograde melanosome transport by expressing 60 different constitutive active (and negative) mutants and succeeded in identifying Rab1A, originally described as a Golgi-resident Rab, as a prime candidate. Endogenous Rab1A protein was found to be localized on mature melanosomes in melanocytes, and its functional ablation either by siRNA-mediated knockdown or by overexpression of a cytosolic form of Rab1A-GTPase-activating protein/TBC1D20 induced perinuclear melanosome aggregation. The results of time-lapse imaging further revealed that long-range anterograde melanosome movements were specifically suppressed in Rab1A-deficient melanocytes, whereas retrograde melanosome transport occurred normally. Taken together, these findings indicate that Rab1A is the first crucial component of the anterograde melanosome transport machinery to be identified in mammalian skin melanocytes.
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Rab1 interacts with SKIP and kinesin 1 to regulate melanosome anterograde transport.
“The Ras-related protein in brain (Rab) 1, which mediates endoplasmic reticulum (ER)-Golgi trafficking, interacts with the SifA and kinesin-interacting protein (SKIP), as well as the anterograde microtubule-dependent motor kinesin 1, to regulate melanosome anterograde transport [ 35 , 36 ]”
From Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing (2023) · cites this paper as [35]
The Introduction reports that Rab1A regulates ER-to-Golgi trafficking, and the Discussion reports Rab1A binding to SKIP and SKIP binding to kinesin-1. The paper also finds that Rab1A is involved in anterograde melanosome transport, but the Discussion calls transport by a Rab1A–SKIP–kinesin-1 complex a possibility requiring further work, not an established mechanism. No page numbers were available in our copy. (LLM, conf=0.90)
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- Authors
- Ishida, M., Ohbayashi, N., Maruta, Y., Ebata, Y., & Fukuda, M.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Fukuda, Mitsunori
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2012-01-01
- Volume
- 125
- Issue
- Pt 21
- Pages
- 5177-87
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2061500309
- Cited by
- 49
- References
- 64
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 2
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (24570206)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- Rab1A, melanosome transport, anterograde transport, melanocytes, microtubule transport, retrograde transport, Rab GTPases, membrane trafficking, melanosome aggregation, Golgi apparatus
- MeSH terms
- Animals, Cell Line, Humans, Melanocytes, Microscopy, Fluorescence, Microtubules, Mutagenesis, Site-Directed, Protein Isoforms, Mutation, Missense, Melanosomes, rab1 GTP-Binding Proteins, Protein Transport, RNA, Small Interfering, Green Fluorescent Proteins, Mice, Gene Knockdown Techniques
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