The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pitx1 and Pitx2 are required for development of hindlimb buds
Abstract
Two closely related homeobox transcription factors, Pitx1 and Pitx2, have been implicated in patterning of lateral plate mesoderm derivatives: Pitx1 for specification of hindlimb identity and Pitx2 for determination of laterality. We show that, together, Pitx1 and Pitx2 are required for formation of hindlimb buds and, when present in limited doses, for development of proximal (femur)and anterior (tibia and digit 1) hindlimb structures. Although Pitx1 is expressed throughout developing hindlimb buds, Pitx2 is not expressed in limb bud mesenchyme itself, but is co-expressed with Pitx1 in the presumptive hindlimb field before bud growth. Thus, Pitx1 and Pitx2genes are required for sustained hindlimb bud growth and formation of hindlimbs.
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Citations
Cites
Fgf8 signalling from the AER is essential for normal limb development
Lewandoski, M., Sun, X., & Martin, G. R. (2000) · Nature Genetics · doi:10.1038/82609 · Cited by 451
Hindlimb patterning and mandible development require the Ptx1 gene
Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M. L., & Drouin, J. (1999) · Development · doi:10.1242/dev.126.9.1805 · Cited by 311
Self-citationRole of Pitx1 upstream of Tbx4 in specification of hindlimb identity
Logan, M., & Tabin, C. J. (1999) · Science · doi:10.1126/science.283.5408.1736 · Cited by 304
Cited by
The evolutionary significance of cis-regulatory mutations
Wray, G. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2063 · Cited by 1,521
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks
Shapiro, M. D., Marks, M. E., Peichel, C. L., Blackman, B. K., Nereng, K. S., Jónsson, B., Schluter, D., & Kingsley, D. M. (2004) · Nature · doi:10.1038/nature02415 · Cited by 846
Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye
Gage, P. J., Rhoades, W., Prucka, S. K., & Hjalt, T. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0691 · Cited by 372
Parallel genetic origins of pelvic reduction in vertebrates
Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604706103 · Cited by 216
Cole, N. J., Tanaka, M., Prescott, A., & Tickle, C. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.039 · Cited by 74
Metadata
- Authors
- Marcil, A., Dumontier, E., Chamberland, M., Camper, S. A., & Drouin, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-01-01
- Volume
- 130
- Issue
- 1
- Pages
- 45-55
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2120255957
- Cited by
- 177
- References
- 3
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marcil, A., Dumontier, E., Chamberland, M., Camper, S. A., & Drouin, J. (2003). Pitx1 and Pitx2 are required for development of hindlimb buds. Development. https://doi.org/10.1242/dev.00192
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