The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland
Abstract
STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF is the physiological activator of STAT3, because in involuting mammary glands of Lif-;/-; mice, pSTAT3 is absent and the STAT3 target, C/EBPδ, is not upregulated. Similar to Stat3knockouts, Lif-;/-; mammary glands exhibit delayed involution, reduced apoptosis and elevated levels of p53. Significantly, Lif-;/-; glands display precocious development during pregnancy, when pSTAT3 is not normally detected. We show that pERK1/2 is significantly reduced in Lif-;/-; glands at this time,suggesting that at this stage LIF mediates its effects through pERK1/2. Inhibition of LIF-mediated ERK1/2 phosphorylation potentiates the proapoptotic effects of STAT3. LIF therefore signals alternately through ERK1/2, then STAT3, to regulate mammary growth and apoptosis.
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Cites
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Auernhammer, C. J., Bousquet, C., & Melmed, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6964 · Cited by 284
Cited by
Macias, H., & Hinck, L. (2012) · WIREs Developmental Biology · doi:10.1002/wdev.35 · Cited by 849
Leukemia inhibitory factor (LIF)
Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.001 · Cited by 478
Stein, T., Morris, J. S., Davies, C. R., Weber-Hall, S. J., Duffy, M.-A., Heath, V. J., Bell, A. K., Ferrier, R. K., Sandilands, G. P., & Gusterson, B. A. (2003) · Breast Cancer Research · doi:10.1186/bcr753 · Cited by 388
Stat3 controls lysosomal-mediated cell death in vivo
Kreuzaler, P. A., Staniszewska, A. D., Li, W., Omidvar, N., Kedjouar, B., Turkson, J., Poli, V., Flavell, R. A., Clarkson, R. W. E., & Watson, C. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2171 · Cited by 312
Self-citationWatson, C. J. (2006) · Breast Cancer Research · doi:10.1186/bcr1401 · Cited by 268
Self-citationPensa, S., Lloyd‐Lewis, B., Sargeant, T. J., Resemann, H. K., Kahn, C. R., & Watson, C. J. (2014) · The FEBS Journal · doi:10.1111/febs.13035 · Cited by 28
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Metadata
- Authors
- Kritikou, E. A., Sharkey, A., Abell, K., Came, P. J., Anderson, E., Clarkson, R. W. E., & Watson, C. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-08-01
- Volume
- 130
- Issue
- 15
- Pages
- 3459-3468
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2099203843
- Cited by
- 201
- References
- 2
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
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