The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation
Open accessAbstract
The hematopoietic and endothelial lineages derive from mesoderm and are thought to develop through the maturation of a common progenitor, the hemangioblast. To investigate the developmental processes that regulate mesoderm induction and specification to the hemangioblast, we generated an embryonic stem cell line with the green fluorescent protein (GFP) targeted to the mesodermal gene, brachyury. After the in vitro differentiation of these embryonic stem cells to embryoid bodies, developing mesodermal progenitors could be separated from those with neuroectoderm potential based on GFP expression. Co-expression of GFP with the receptor tyrosine kinase Flk1 revealed the emergence of three distinct cell populations,GFP-Flk1-, GFP+Flk1- and GFP+Flk1+ cells, which represent a developmental progression ranging from pre-mesoderm to prehemangioblast mesoderm to the hemangioblast.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
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Cited by
Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477
Kennedy, M., D'Souza, S. L., Lynch-Kattman, M., Schwantz, S., & Keller, G. (2007) · Blood · doi:10.1182/blood-2006-09-047704 · Cited by 483
Self-citationvan den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A.-K., Nowotschin, S., Turner, D. A., & Martinez Arias, A. (2014) · Development · doi:10.1242/dev.113001 · Cited by 478
Metadata
- Authors
- Fehling, H. J., Lacaud, G., Kubo, A., Kennedy, M., Robertson, S., Keller, G., & Kouskoff, V.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-09-01
- Volume
- 130
- Issue
- 17
- Pages
- 4217-4227
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2004196170
- Cited by
- 500
- References
- 5
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fehling, H. J., Lacaud, G., Kubo, A., Kennedy, M., Robertson, S., Keller, G., & Kouskoff, V. (2003). Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development. https://doi.org/10.1242/dev.00589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
