The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation
Abstract
PAR proteins distribute asymmetrically across the anterior-posterior axis of the 1-cell-stage C. elegans embryo, and function to establish subsequent anterior-posterior asymmetries. By the end of the 4-cell stage,anteriorly localized PAR proteins, such as PAR-3 and PAR-6, redistribute to the outer, apical surfaces of cells, whereas posteriorly localized PAR proteins, such as PAR-1 and PAR-2, redistribute to the inner, basolateral surfaces. Because PAR proteins are provided maternally, distinguishing apicobasal from earlier anterior-posterior functions requires a method that selectively prevents PAR activity after the 1-cell stage. In the present study we generated hybrid PAR proteins that are targeted for degradation after the 1-cell stage. Embryos containing the hybrid PAR proteins had normal anterior-posterior polarity, but showed defects in apicobasal asymmetries associated with gastrulation. Ectopic separations appeared between lateral surfaces of cells that are normally tightly adherent, cells that ingress during gastrulation failed to accumulate nonmuscle myosin at their apical surfaces and ingression was slowed. Thus, PAR proteins function in both apicobasal and anterior-posterior asymmetry during the first few cell cycles of embryogenesis.
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Citations
Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 1×
“Biochemical studies of PAR-3, PAR-6 and PKC-3 homologs in mammalian cells have shown that these proteins can bind to one another directly (Joberty et al., 2000; Lin et al., 2000), indicating that interactions between all three proteins might be necessary to stabilize a complex with apical PAR-3.”
BackgroundA mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Integrated activity of PDZ protein complexes regulates epithelial polarity
Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology · doi:10.1038/ncb897 · Cited by 435
Müller, H. A., & Wieschaus, E. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.1.149 · Cited by 384
Cited by
Mechanical control of tissue and organ development
Mammoto, T., & Ingber, D. E. (2010) · Development · doi:10.1242/dev.024166 · Cited by 850
The PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 758
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621
Self-citationApical constriction: A cell shape change that can drive morphogenesis
Sawyer, J. M., Harrell, J. R., Shemer, G., Sullivan-Brown, J., Roh-Johnson, M., & Goldstein, B. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.009 · Cited by 448
Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation
Simões, S. D. M., Blankenship, J. T., Weitz, O., Farrell, D. L., Tamada, M., Fernandez-Gonzalez, R., & Zallen, J. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.011 · Cited by 274
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
Roh-Johnson, M., Shemer, G., Higgins, C. D., McClellan, J. H., Werts, A. D., Tulu, U. S., Gao, L., Betzig, E., Kiehart, D. P., & Goldstein, B. (2012) · Science · doi:10.1126/science.1217869 · Cited by 274
Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins
Armenti, S. T., Lohmer, L. L., Sherwood, D. R., & Nance, J. (2014) · Development · doi:10.1242/dev.115048 · Cited by 124
Self-citationFazeli, G., Trinkwalder, M., Irmisch, L., & Wehman, A. M. (2016) · Journal of Cell Science · doi:10.1242/jcs.190223 · Cited by 50
Metadata
- Authors
- Nance, J., Munro, E. M., & Priess, J. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-11-15
- Volume
- 130
- Issue
- 22
- Pages
- 5339-5350
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2011974546
- Cited by
- 189
- References
- 5
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
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