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Mouse placenta is a major hematopoietic organ

Alvarez-Silva, Marcio, Belo-Diabangouaya, Patricia, Salaün, Josselyne, Dieterlen-Lièvre, Françoise·2003·Development
DOI 10.1242/dev.00755
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Abstract

Placenta and yolk sac from 8- to 17-day-old (E8-E17) mouse embryos/fetuses were investigated for the presence of in vitro clonogenic progenitors. At E8-E9, the embryonic body from the umbilicus caudalwards was also analysed. Fetal liver was analysed beginning on E10. At E8, between five and nine somite pairs (sp), placenta, yolk sac and embryonic body yielded no progenitors. The first progenitors appeared at E8.5 at the stage of 15 sp in the yolk sac, 18 sp in the embryonic body, 20 sp in the placenta and only at E12 in the fetal liver (absent at E10, at E11 not determined). Progenitors with a high proliferation potential that could be replated for two months, as well as the whole range of myeloid progenitors, were found at all stages in all organs. However, the earliest of these progenitors (these yielding large, multilineage colonies) were 2-4 times more frequent in the placenta than in the yolk sac or fetal liver. In the fetal liver, late progenitors were more frequent and the cellularity increased steeply with developmental age. Thus, the fetal liver,which is a recognized site for amplification and commitment, has a very different hematopoietic developmental profile from placenta or yolk sac. Placentas were obtained from GFP transgenic embryos in which only the embryonic contribution expressed the transgene. 80% of the colonies derived from these placental cells were GFP+, and so originated from the fetal component of the placenta. These data point to the placenta as a major hematopoietic organ that is active during most of pregnancy.

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Metadata

Authors
Alvarez-Silva, M., Belo-Diabangouaya, P., Salaün, J., & Dieterlen-Lièvre, F.
Affiliations
Laboratoire d'Embryologie cellulaire et moléculaire du CNRS et du Collège de France, 49 bis, avenue de la Belle Gabrielle, 94736 Nogent s/Marne cedex, France
Venue
Development
Publisher
The Company of Biologists
Published
2003-11-15
Volume
130
Issue
22
Pages
5437-5444
ISSN
  • 1477-9129
  • 0950-1991
DOI
10.1242/dev.00755
Cited by
175
References
1
Language
en

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CoChat. (2026). Citation check: Mouse placenta is a major hematopoietic organ. https://app.cochat.ai/papers/10.1242/dev.00755
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Alvarez-Silva, M., Belo-Diabangouaya, P., Salaün, J., & Dieterlen-Lièvre, F. (2003). Mouse placenta is a major hematopoietic organ. Development. https://doi.org/10.1242/dev.00755