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Cited by 335

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4

Hardtke, Christian S., Ckurshumova, Wenzislava, Vidaurre, Danielle P., Singh, Sasha A., Stamatiou, George, Tiwari, Shiv B., Hagen, Gretchen, Guilfoyle, Tom J., Berleth, Thomas·2004·Development
DOI 10.1242/dev.00925
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Abstract

Transcription factors of the auxin response factor (ARF) family have been implicated in auxin-dependent gene regulation, but little is known about the functions of individual ARFs in plants. Here, interaction assays, expression studies and combinations of multiple loss- and gain-of-function mutants were used to assess the roles of two ARFs, NONPHOTOTROPIC HYPOCOTYL 4 (NPH4/ARF7)and MONOPTEROS (MP/ARF5), in Arabidopsis development. Both MP and NPH4 interact strongly and selectively with themselves and with each other,and are expressed in vastly overlapping domains. We show that the regulatory properties of both genes are far more related than suggested by their single mutant phenotypes. NPH4 and MP are capable of controlling both axis formation in the embryo and auxin-dependent cell expansion. Interaction of MP and NPH4 in Arabidopsis plants is indicated by their joint requirement in a number of auxin responses and by synergistic effects associated with the co-overexpression of both genes. Finally, we demonstrate antagonistic interaction between ARF and Aux/IAAgene functions in Arabidopsis development. Overexpression of MP suppresses numerous defects associated with a gain-of-function mutation in BODENLOS (BDL)/IAA12. Together these results provide evidence for the biological relevance of ARF-ARF and ARF-Aux/IAA interaction in Arabidopsis plants and demonstrate that an individual ARF can act in both invariantly programmed pattern formation as well as in conditional responses to external signals.

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Metadata

Authors
Hardtke, C. S., Ckurshumova, W., Vidaurre, D. P., Singh, S. A., Stamatiou, G., Tiwari, S. B., Hagen, G., Guilfoyle, T. J., & Berleth, T.
Venue
Development
Publisher
The Company of Biologists
Published
2004-03-01
Volume
131
Issue
5
Pages
1089-1100
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.00925
OpenAlex
W2005180977
Cited by
335
References
50
FWCI
28.12
Type
journal article
Language
en
Open access
closed

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