The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
Open accessAbstract
The heart maintains structural and functional integrity during years of continual contraction, but the extent to which new cell creation participates in cardiac homeostasis is unclear. Here, we assessed cellular and molecular mechanisms of cardiac homeostasis in zebrafish, which display indeterminate growth and possess an unusual capacity to regenerate after acute cardiac injury. Lowering fish density in the aquarium triggered rapid animal growth and robust cardiomyocyte proliferation throughout the adult ventricle, greater than that observed during slow animal growth or size maintenance. Rapid animal growth also induced strong expression of the embryonic epicardial markers raldh2 (aldh1a2) and tbx18 in adult epicardial tissue. Pulse-chase dye labeling experiments revealed that the epicardium recurrently contributes cells to the ventricular wall, indicating an active homeostatic process. Inhibition of signaling by Fibroblast growth factors(Fgfs) decreased this epicardial supplementation of the ventricular wall in growing zebrafish, and led to spontaneous ventricular scarring in animals maintaining cardiac size. Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis.
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Cites
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Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
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Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514
Kikuchi, K., Holdway, J. E., Major, R. J., Blum, N., Dahn, R. D., Begemann, G., & Poss, K. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.010 · Cited by 461
Self-citationAdvances in understanding tissue regenerative capacity and mechanisms in animals
Poss, K. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2879 · Cited by 416
Self-citationWang, J., Panáková, D., Kikuchi, K., Holdway, J. E., Gemberling, M., Burris, J. S., Singh, S. P., Dickson, A. L., Lin, Y.-F., Sabeh, M. K., et al. (2011) · Development · doi:10.1242/dev.068601 · Cited by 377
Self-citationGemberling, M., Karra, R., Dickson, A. L., & Poss, K. D. (2015) · eLife · doi:10.7554/elife.05871 · Cited by 302
Self-citationMyocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish
González-Rosa, J. M., Sharpe, M., Field, D., Soonpaa, M. H., Field, L. J., Burns, C. E., & Burns, C. G. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.021 · Cited by 264
The Role of the Epicardium During Heart Development and Repair
Quijada, P., Trembley, M. A., & Small, E. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315857 · Cited by 201
Pennisi, D. J., & Mikawa, T. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.023 · Cited by 59
Metadata
- Authors
- Wills, A. A., Holdway, J. E., Major, R. J., & Poss, K. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2008-01-01
- Volume
- 135
- Issue
- 1
- Pages
- 183-192
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2147908244
- Cited by
- 174
- References
- 2
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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