The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
Open accessAbstract
Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size. Here, we created a genetic cell ablation model in zebrafish that facilitates inducible destruction of a high percentage of cardiomyocytes. Cell-specific depletion of over 60% of the ventricular myocardium triggered signs of cardiac failure that were not observed after partial ventricular resection, including reduced animal exercise tolerance and sudden death in the setting of stressors. Massive myocardial loss activated robust cellular and molecular responses by endocardial, immune, epicardial and vascular cells. Destroyed cardiomyocytes fully regenerated within several days, restoring cardiac anatomy, physiology and performance. Regenerated muscle originated from spared cardiomyocytes that acquired ultrastructural and electrophysiological characteristics of de-differentiation and underwent vigorous proliferation. Our study indicates that genetic depletion of cardiomyocytes, even at levels so extreme as to elicit signs of cardiac failure, can be reversed by natural regenerative capacity in lower vertebrates such as zebrafish.
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Cites
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
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Self-citationCardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
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Cited by
Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.032 · Cited by 909
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
Porrello, E. R., Mahmoud, A. I., Simpson, E., Johnson, B. A., Grinsfelder, D., Canseco, D., Mammen, P. P., Rothermel, B. A., Olson, E. N., & Sadek, H. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208863110 · Cited by 746
The zebrafish as a model for complex tissue regeneration
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Self-citationAnimal Models of Heart Failure: A Scientific Statement From the American Heart Association
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Modulation of tissue repair by regeneration enhancer elements
Kang, J., Hu, J., Karra, R., Dickson, A. L., Tornini, V. A., Nachtrab, G., Gemberling, M., Goldman, J. A., Black, B. L., & Poss, K. D. (2016) · Nature · doi:10.1038/nature17644 · Cited by 316
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Metadata
- Authors
- Wang, J., Panáková, D., Kikuchi, K., Holdway, J. E., Gemberling, M., Burris, J. S., Singh, S. P., Dickson, A. L., Lin, Y.-F., Sabeh, M. K., Werdich, A. A., Yelon, D., MacRae, C. A., & Poss, K. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-08-15
- Volume
- 138
- Issue
- 16
- Pages
- 3421-3430
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2099997602
- Cited by
- 377
- References
- 42
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, J., Panáková, D., Kikuchi, K., Holdway, J. E., Gemberling, M., Burris, J. S., Singh, S. P., Dickson, A. L., Lin, Y.-F., Sabeh, M. K., Werdich, A. A., Yelon, D., MacRae, C. A., & Poss, K. D. (2011). The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. https://doi.org/10.1242/dev.068601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
