The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
Abstract
In developing limb skin, peripheral nerves are required for arterial differentiation, and guide the pattern of arterial branching. In vitro experiments suggest that nerve-derived VEGF may be important for arteriogenesis, but its role in vivo remains unclear. Using a series of nerve-specific Cre lines, we show that VEGF derived from sensory neurons,motoneurons and/or Schwann cells is required for arteriogenesis in vivo. Arteriogenesis also requires endothelial expression of NRP1, an artery-specific coreceptor for VEGF164 that is itself induced by VEGF. Our results provide the first evidence that VEGF is necessary for arteriogenesis from a primitive capillary plexus in vivo, and show that in limb skin the nerve is indeed the principal source of this signal. They also suggest a model in which a `winner-takes-all' competition for VEGF may control arterial differentiation, with the outcome biased by a VEGF164-NRP1 positive-feedback loop. Our results also demonstrate that nerve-vessel alignment is a necessary, but not sufficient, condition for nerve-induced arteriogenesis. Different mechanisms therefore probably underlie these endothelial patterning and differentiation processes.
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Metadata
- Authors
- Mukouyama, Y.-S., Gerber, H.-P., Ferrara, N., Gu, C., & Anderson, D. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-03-01
- Volume
- 132
- Issue
- 5
- Pages
- 941-952
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2168468808
- Cited by
- 266
- References
- 38
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
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