The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
Abstract
The extra-embryonic endoderm lineage plays a major role in the nutritive support of the embryo and is required for several inductive events, such as anterior patterning and blood island formation. Blastocyst-derived embryonic stem (ES) and trophoblast stem (TS) cell lines provide good models with which to study the development of the epiblast and trophoblast lineages,respectively. We describe the derivation and characterization of cell lines that are representative of the third lineage of the blastocyst –extra-embryonic endoderm. Extra-embryonic endoderm (XEN) cell lines can be reproducibly derived from mouse blastocysts and passaged without any evidence of senescence. XEN cells express markers typical of extra-embryonic endoderm derivatives, but not those of the epiblast or trophoblast. Chimeras generated by injection of XEN cells into blastocysts showed exclusive contribution to extra-embryonic endoderm cell types. We used female XEN cells to investigate the mechanism of X chromosome inactivation in this lineage. We observed paternally imprinted X-inactivation, consistent with observations in vivo. Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage.
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Citations
Cites
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528
Cited by
Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Self-citationStock, J. K., Giadrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G., & Pombo, A. (2007) · Nature Cell Biology · doi:10.1038/ncb1663 · Cited by 650
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
Rossant, J., & Tam, P. P. L. (2009) · Development · doi:10.1242/dev.017178 · Cited by 631
Self-citationDistinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
Plusa, B., Piliszek, A., Frankenberg, S., Artus, J., & Hadjantonakis, A.-K. (2008) · Development · doi:10.1242/dev.021519 · Cited by 556
The role of FGF/Erk signaling in pluripotent cells
Lanner, F., & Rossant, J. (2010) · Development · doi:10.1242/dev.050146 · Cited by 408
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Metadata
- Authors
- Kunath, T., Arnaud, D., Uy, G. D., Okamoto, I., Chureau, C., Yamanaka, Y., Heard, E., Gardner, R. L., Avner, P., & Rossant, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-04-01
- Volume
- 132
- Issue
- 7
- Pages
- 1649-1661
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2142303444
- Cited by
- 403
- References
- 2
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- closed
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