The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The role of FGF/Erk signaling in pluripotent cells
Abstract
Fibroblast growth factor (FGF) signaling controls fundamental processes such as proliferation, differentiation and migration throughout mammalian development. Here we discuss recent discoveries that implicate FGF/Erk signaling in the control of pluripotency and lineage specification in several different stem cell states, including the separation of pluripotent epiblast and primitive endoderm in the blastocyst, the lineage priming of embryonic stem (ES) cells, and in the stabilization of the metastable state of mouse epiblast and human ES cells. Understanding how extrinsic signals such as FGF regulate different stem cell states will be crucial to harvest the clinical promise of induced pluripotent and embryo-derived stem cells.
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Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Self-citationA parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
Niwa, H., Ogawa, K., Shimosato, D., & Adachi, K. (2009) · Nature · doi:10.1038/nature08113 · Cited by 872
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development
Saba‐El‐Leil, M. K., Vella, F. D. J., Vernay, B., Voisin, L., Chen, L., Labrecque, N., Ang, S., & Meloche, S. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor939 · Cited by 366
Stavridis, M. P., Collins, B. J., & Storey, K. G. (2010) · Development · doi:10.1242/dev.043117 · Cited by 124 · cited 2×
“support a neuronal suppression function of FGF in EpiSCs (Stavridis et al., 2010).”
Background
Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq
Blakeley, P., Fogarty, N. M. E., del Valle, I., Wamaitha, S. E., Hu, T. X., Elder, K., Snell, P., Christie, L., Robson, P., & Niakan, K. K. (2015) · Development · doi:10.1242/dev.123547 · Cited by 466
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape
Marco, E., Karp, R. L., Guo, G., Robson, P., Hart, A. H., Trippa, L., & Yuan, G.-C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408993111 · Cited by 268
Ohnishi, Y., Huber, W., Tsumura, A., Kang, M., Xenopoulos, P., Kurimoto, K., Oleś, A. K., Araúzo-Bravo, M. J., Saitou, M., Hadjantonakis, A.-K., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2881 · Cited by 300
Metadata
- Authors
- Lanner, F., & Rossant, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2010-10-15
- Volume
- 137
- Issue
- 20
- Pages
- 3351-3360
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1990180850
- Cited by
- 408
- References
- 6
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
