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Cited by 338

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Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration

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Lee, Yoonsung, Grill, Sara, Sanchez, Angela, Murphy-Ryan, Maureen, Poss, Kenneth D.·2005·Development
DOI 10.1242/dev.02101
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Abstract

During appendage regeneration in urodeles and teleosts, tissue replacement is precisely regulated such that only the appropriate structures are recovered, a phenomenon referred to as positional memory. It is believed that there exists, or is quickly established after amputation, a dynamic gradient of positional information along the proximodistal (PD) axis of the appendage that assigns region-specific instructions to injured tissue. These instructions specify the amount of tissue to regenerate, as well as the rate at which regenerative growth is to occur. A striking theme among many species is that the rate of regeneration is more rapid in proximally amputated appendages compared with distal amputations. However, the underlying molecular regulation is unclear. Here, we identify position-dependent differences in the rate of growth during zebrafish caudal fin regeneration. These growth rates correlate with position-dependent differences in blastemal length, mitotic index and expression of the Fgf target genes mkp3, sef and spry4. To address whether PD differences in amounts of Fgf signaling are responsible for position-dependent blastemal function, we have generated transgenic fish in which Fgf receptor activity can be experimentally manipulated. We find that the level of Fgf signaling exhibits strict control over target gene expression, blastemal proliferation and regenerative growth rate. Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage.

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  1. Akimenko, M. A., Mari-Beffa, M., Becerra, J. and Geraudie,J. (2003). Old questions, new tools, and some answers to the mystery of fin regeneration. Dev. Dyn.226,190-201. · DOI · Paper page
  2. Amaya, E., Musci, T. J. and Kirschner, M. W.(1991). Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell66,257-270. · DOI · Paper page
  3. Beck, C. W., Christen, B. and Slack, J. M.(2003). Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate. Dev. Cell5, 429-439. · DOI · Paper page
  4. Crawford, K. and Stocum, D. L. (1988). Retinoic acid proximalizes level-specific properties responsible for intercalary regeneration in axolotl limbs. Development104,703-712. · DOI
  5. da Silva, S. M., Gates, P. B. and Brockes, J. P.(2002). The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration. Dev. Cell3, 547-555. · DOI · Paper page
  6. D'Jamoos, C. A., McMahon, G. and Tsonis, P. A.(1998). Fibroblast growth factor receptors regulate the ability for hindlimb regeneration in Xenopus laevis. Wound Repair Regen. 6,388-397. · DOI
  7. Draper, B. W., Stock, D. W. and Kimmel, C. B.(2003). Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Development130,4639-4654. · DOI · Paper page
  8. Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Munsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., Mathers, J., Keyse, S. M., Storey,K. and Tickle, C. (2003). Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Curr. Biol.13,1009-1018. · DOI · Paper page
  9. Echeverri, K. and Tanaka, E. M. (2005). Proximodistal patterning during limb regeneration. Dev. Biol.279,391-401. · DOI
  10. Furthauer, M., Lin, W., Ang, S. L., Thisse, B. and Thisse,C. (2002). Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell Biol.4, 170-174. · DOI · Paper page
  11. Griffin, K., Patient, R. and Holder, N. (1995). Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. Development121,2983-2994. · DOI · Paper page
  12. Grunwald, D. J. and Eisen, J. S. (2002). Headwaters of the zebrafish – emergence of a new model vertebrate. Nat. Rev. Genet.3,717-724. · DOI · Paper page
  13. Halloran, M. C., Sato-Maeda, M., Warren, J. T., Su, F., Lele,Z., Krone, P. H., Kuwada, J. Y. and Shoji, W. (2000). Laser-induced gene expression in specific cells of transgenic zebrafish. Development127,1953-1960. · DOI · Paper page
  14. Higashijima, S., Okamoto, H., Ueno, N., Hotta, Y. and Eguchi,G. (1997). High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Dev. Biol.192,289-299. · DOI · Paper page
  15. Iten, L. E. and Bryant, S. V. (1976). Regeneration from different levels along the tail of the newt, Notophthalmus viridescens. J. Exp. Zool.196,293-306. · DOI
  16. Johnson, S. L. and Weston, J. A. (1995). Temperature-sensitive mutations that cause stage-specific defects in Zebrafish fin regeneration. Genetics141,1583-1595. · DOI · Paper page
  17. Kawakami, Y., Rodriguez-Leon, J., Koth, C. M., Buscher, D.,Itoh, T., Raya, A., Ng, J. K., Esteban, C. R., Takahashi, S., Henrique, D. et al. (2003). MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat. Cell Biol.5, 513-519. · DOI · Paper page
  18. Maden, M. (1976). Blastemal kinetics and pattern formation during amphibian limb regeneration. J. Embryol. Exp. Morphol.36,561-574. · doi:10.1242/dev.36.3.561
  19. Maden, M. (1982). Vitamin A and pattern formation in the regenerating limb. Nature295,672-675. · DOI · Paper page
  20. Mercader, N., Tanaka, E. M. and Torres, M.(2005). Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins. Development132,4131-4142. · DOI · Paper page
  21. Moreno, T. A. and Kintner, C. (2004). Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev. Cell6,205-218. · DOI · Paper page
  22. Morgan, T. H. (1906). The physiology of regeneration. J. Exp. Zool.3,457-503. · doi:10.1002/jez.1400030402
  23. Nechiporuk, A., Poss, K. D., Johnson, S. L. and Keating, M. T. (2003). Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. Dev. Biol.258,291-306. · DOI
  24. Poss, K. D., Shen, J., Nechiporuk, A., McMahon, G., Thisse, B.,Thisse, C. and Keating, M. T. (2000). Roles for Fgf signaling during zebrafish fin regeneration. Dev. Biol.222,347-358. · DOI · Paper page
  25. Poss, K. D., Wilson, L. G. and Keating, M. T.(2002a). Heart regeneration in zebrafish. Science298,2188-2190. · DOI · Paper page
  26. Poss, K. D., Nechiporuk, A., Hillam, A. M., Johnson, S. L. and Keating, M. T. (2002b). Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development129,5141-5149. · DOI · Paper page
  27. Poss, K. D., Keating, M. T. and Nechiporuk, A.(2003). Tales of regeneration in zebrafish. Dev. Dyn.226,202-210. · DOI · Paper page
  28. Poulin, M. L., Patrie, K. M., Botelho, M. J., Tassava, R. A. and Chiu, I. M. (1993). Heterogeneity in the expression of fibroblast growth factor receptors during limb regeneration in newts(Notophthalmus viridescens). Development119,353-361. · DOI
  29. Quint, E., Smith, A., Avaron, F., Laforest, L., Miles, J.,Gaffield, W. and Akimenko, M. A. (2002). Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine. Proc. Natl. Acad. Sci. USA99,8713-8718. · DOI · Paper page
  30. Raya, A., Koth, C. M., Buscher, D., Kawakami, Y., Itoh, T.,Raya, R. M., Sternik, G., Tsai, H. J., Rodriguez-Esteban, C. and Izpisua-Belmonte, J. C. (2003). Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proc. Natl. Acad. Sci. USA100,11889-11895. · DOI · Paper page
  31. Scadding, S. R. and Maden, M. (1994). Retinoic acid gradients during limb regeneration. Dev. Biol.162,608-617. · doi:10.1006/dbio.1994.1114
  32. Schnapp, E., Kragl, M., Rubin, L. and Tanaka, E. M.(2005). Hedgehog signaling controls dorsoventral patterning,blastema cell proliferation and cartilage induction during axolotl tail regeneration. Development132,3243-3253. · DOI · Paper page
  33. Shiotsugu, J., Katsuyama, Y., Arima, K., Baxter, A., Koide, T.,Song, J., Chandraratna, R. A. and Blumberg, B. (2004). Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development131,2653-2667. · DOI
  34. Spallanzani, A. (1769). An essary on animal reproductions. (Trans. M. Maty) London: T. Becket.
  35. Tawk, M., Tuil, D., Torrente, Y., Vriz, S. and Paulin, D.(2002). High-efficiency gene transfer into adult fish: a new tool to study fin regeneration. Genesis32, 27-31. · DOI
  36. Tsang, M., Maegawa, S., Kiang, A., Habas, R., Weinberg, E. and Dawid, I. B. (2004). A role for MKP3 in axial patterning of the zebrafish embryo. Development131,2769-2779. · DOI
  37. Tsonis, P. A. (1996). Limb Regeneration. Cambridge: Cambridge University Press.
  38. White, J. A., Boffa, M. B., Jones, B. and Petkovich, M.(1994). A zebrafish retinoic acid receptor expressed in the regenerating caudal fin. Development120,1861-1872. · DOI
  39. Yokoyama, H., Yonei-Tamura, S., Endo, T., Izpisua Belmonte, J. C., Tamura, K. and Ide, H. (2000). Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds. Dev. Biol.219,18-29. · DOI
  40. Yokoyama, H., Ide, H. and Tamura, K. (2001). FGF-10 stimulates limb regeneration ability in Xenopus laevis.Dev. Biol.233,72-79. · DOI

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Metadata

Authors
Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., & Poss, K. D.
Venue
Development
Publisher
The Company of Biologists
Published
2005-12-01
Volume
132
Issue
23
Pages
5173-5183
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.02101
OpenAlex
W2088130353
Cited by
338
References
1
FWCI
4.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. https://app.cochat.ai/papers/10.1242/dev.02101
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Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., & Poss, K. D. (2005). Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Development. https://doi.org/10.1242/dev.02101

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