The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
Open accessAbstract
The Notch pathway regulates cell fate determination in numerous developmental processes. Here we report that Notch2 acts non-redundantly to control the processes of nephron segmentation through an Rbp-J-dependent process. Notch1 and Notch2 are detected in the early renal vesicle. Genetic analysis reveals that only Notch2 is required for the differentiation of proximal nephron structures (podocytes and proximal convoluted tubules)despite the presence of activated Notch1 in the nuclei of putative proximal progenitors. The inability of endogenous Notch1 to compensate for Notch2 deficiency may reflect sub-threshold Notch1 levels in the nucleus. In line with this view, forced expression of a γ-secretase-independent form of Notch1 intracellular domain drives the specification of proximal fates where all endogenous, ligand-dependent Notch signaling is blocked by aγ-secretase inhibitor. These results establish distinct (non-redundant),instructive roles for Notch receptors in nephron segmentation.
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Cites
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Cited by
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
Notch signaling controls liver development by regulating biliary differentiation
Zong, Y., Panikkar, A., Xu, J., Antoniou, A., Raynaud, P., Lemaigre, F., & Stanger, B. Z. (2009) · Development · doi:10.1242/dev.029140 · Cited by 444
Canonical and Non-Canonical Notch Ligands
D’Souza, B., Meloty-Kapella, L., & Weinmaster, G. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92003-6 · Cited by 362
Georgas, K., Rumballe, B., Valerius, M. T., Chiu, H. S., Thiagarajan, R. D., Lesieur, E., Aronow, B. J., Brunskill, E. W., Combes, A. N., Tang, D., et al. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.578 · Cited by 275
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Metadata
- Authors
- Cheng, H.-T., Kim, M., Valerius, M. T., Surendran, K., Schuster-Gossler, K., Gossler, A., McMahon, A. P., & Kopan, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 134
- Issue
- 4
- Pages
- 801-811
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2145111609
- Cited by
- 351
- References
- 2
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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